Navigation Links
Aiming at Multiple Alzheimer's Proteins May be Key to Success
Date:10/21/2008

r's-related proteins before they begin to misfold and start their toxic buildup. "Right now, we're treating the symptoms of the disease -- only slowing cognitive decline and memory loss in patients," says Dr. Weaver. "My colleagues and I are using this grant to design drugs that may one day prevent or even reverse progression of Alzheimer's disease."

The design strategy begins at Dalhousie University where researchers are creating new, unique drug compounds and testing each drug's ability to bind to both proteins and prevent shape changes. To date, Dr. Weaver's laboratory has produced more than 240 variations of the most effective compound. Once identified, these synthesized compounds are sent for further analysis to Edwin De Pauw, Ph.D. and his group at the University of Liege in Belgium. Promising compounds that pass this second step in testing then move on to preliminary safety and efficacy investigations using animal models in the laboratory of Ottavio Arancio, M.D., Ph.D. at Columbia University Medical Center in New York.

Since accepting the award from AHAF last year, this international team has made impressive progress. These easily reproducible chemical compounds have shown a remarkable ability to prevent misfolding of both proteins in the Dalhousie laboratory. This activity has been confirmed at the University of Liege, and exciting results are reported at Columbia. "Our lead compound is very effective in mice with conditions similar to Alzheimer's. It can be delivered orally, inhibits aggregation of these proteins, protects brain cells from beta amyloid damage, restores normal memory functioning and shows no toxicity at high doses," says Dr. Weaver. According to AHAF's Director of Research Grants, Guy Eakin, Ph.D., "This work is particularly important because Alzheimer's disease patients are often taking several medications for other health conditions. Rather than give them a 'cocktail' of drugs that might produce harmful interactions, Dr. Wea
'/>"/>

SOURCE American Health Assistance Foundation
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. The Multiple Myeloma Research Consortium (MMRC) and Proteolix Initiate Phase 2 Clinical Trial Investigating Carfilzomib for the Treatment of Multiple Myeloma
2. Millennium Initiates Clinical Trial to EVOLVE the Treatment of Patients with Newly Diagnosed Multiple Myeloma
3. Multiple Myeloma Research Consortium (MMRC) Partners with Novartis to Advance Phase II Study of Deacetylase Inhibitor
4. Kosan Opens Registration Program for Lead Hsp90 Inhibitor, Tanespimycin, in Multiple Myeloma
5. Multiple NIH Phase 2 HIV Vaccine Trials Using Vicals Technology Produce Encouraging Results
6. TorreyPines Therapeutics Initiates a Phase I Multiple Dose Clinical Trial of Tezampanel
7. Kosan Receives Completed Special Protocol Assessment for TIME-1 Pivotal Phase 3 Trial of Tanespimycin in Multiple Myeloma
8. TorreyPines Therapeutics Completes Phase I Multiple Dose Clinical Trial of NGX267, a Selective M1 Agonist for the Potential Treatment of Cognitive Impairment Associated with Schizophrenia
9. Pharmacopeia Announces Positive Results from Phase 1 Multiple Ascending Dose Study of PS433540 (DARA)
10. Phase III Clinical Trial in Newly Diagnosed Multiple Myeloma Stopped Early Due to Highly Significant Efficacy Advantage of VELCADE(R) (Bortezomib) for Injection Based Therapy Across All Endpoints
11. Velcura Therapeutics, Inc. Reports Positive Pre-IND Meeting With FDA and Plans Early Clinical Trials for New Drug to Treat Multiple Myeloma Bone Disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)...  Monarch America Inc. (OTCQB: CANK) ("Monarch America" or ... provide this review of the Company,s recent achievements and ... "Over this past year, we achieved many of our ... to say that Monarch America is in a stronger ... been," stated Eric Hagen , CEO of Monarch ...
(Date:12/19/2014)... FORT WORTH, Texas , December 18, 2014 ... is a networked software application/module that is used ... and related images. RIS comprises a patient tracking ... tracking system. The integration of RIS with HIS ... is used for patient registration and patient scheduling, ...
(Date:12/19/2014)... --Research and Markets ( http://www.researchandmarkets.com/research/942kh3/micro_market ) ... Market Monitor: North American Dermatology Diagnostic Devices Market" ... http://photos.prnewswire.com/prnh/20130307/600769 Cosmetic surgeries ... resulted in fueling the overall demand of the ... these dermatology devices is to assist in identifying ...
Breaking Medicine Technology:Monarch America Inc. CEO Reviews Recent Achievements and Provides Outlook for 2015 2Monarch America Inc. CEO Reviews Recent Achievements and Provides Outlook for 2015 3The Global Radiology Information Systems Market is Expected to Grow at a CAGR of 7.5% from 2014 to 2019 2The Global Radiology Information Systems Market is Expected to Grow at a CAGR of 7.5% from 2014 to 2019 3Micro Market Monitor: North American Dermatology Diagnostic Devices Market 2Micro Market Monitor: North American Dermatology Diagnostic Devices Market 3
(Date:12/19/2014)... CA (PRWEB) December 19, 2014 ... corporation dedicated to developing educational events, tools and ... Rouxbe Cooking School , the world’s leading ... the prescription every human being needs: Culinary Rx. ... plant-based cooking course, Culinary Rx, scheduled for debut ...
(Date:12/19/2014)... 20, 2014 An evening dress is perfect ... lady’s closet. Discount-Dress.com, a distinguished dresses retailer, has unveiled its ... dresses in this great shopping platform. Customers can ... staff's hard work, Discount-Dress.com has been accepted and praised by ... and easier shopping stage for clients. In order to expand ...
(Date:12/19/2014)... 2014 (HealthDay News) -- All children should have their ... preferably every year, eye experts say. The new ... panel of the U.S. National Center for Children,s Vision ... age group require screening for eye problems, particularly vision ... amblyopia ("lazy eye") and strabismus (a disorder of eye ...
(Date:12/19/2014)... who have lost all their teeth have faster decreases in ... least some of their teeth, a new study says. ... early warning of increased risk of physical and mental decline ... findings don,t prove that tooth loss causes the physical or ... 60 and older. People with no remaining teeth did about ...
(Date:12/19/2014)... LENEXA, Kan. (PRWEB) December 19, 2014 ... dedicated exclusively to healthcare providers, has been retained to ... for Johnson Memorial Hospital in Franklin, Ind. The top ... Smith has recently placed more than 900 healthcare executives ... 100-bed, county-owned, full service hospital providing care to the ...
Breaking Medicine News(10 mins):Health News:The Plantrician Project and the Rouxbe Cooking School Join Forces to Develop Culinary Rx – a Plant-Prescription Course 2Health News:The Plantrician Project and the Rouxbe Cooking School Join Forces to Develop Culinary Rx – a Plant-Prescription Course 3Health News:The Plantrician Project and the Rouxbe Cooking School Join Forces to Develop Culinary Rx – a Plant-Prescription Course 4Health News:Attractive Evening Dresses Announced by Discount-Dress.com 2Health News:Preschoolers Need Eye Screening, Experts Say 2Health News:Loss of Teeth Linked to Physical, Mental Decline in Study 2Health News:Johnson Memorial Hospital Retains B. E. Smith to Recruit New Chief Financial Officer 2Health News:Johnson Memorial Hospital Retains B. E. Smith to Recruit New Chief Financial Officer 3
... papillomavirus vaccine might promote promiscuity, a national survey of ... respondents did not believe the HPV vaccine protected them ... by University of Illinois at Chicago and University of ... of the Journal of Adolescent Health . ...
... a Band-Aid for damaged muscle , THURSDAY, Oct. 15 (HealthDay ... of literally rebuilding a broken heart -- creating a strip ... newly identified human cardiac master stem cell. , "This work ... Kenneth Chien, director of the Massachusetts General Center for Cardiovascular ...
... for Disease Control and Prevention (CDC) reporting that the H1N1 ... the American Red Cross has a set of tips for ... who has the flu. , (Logo: http://www.newscom.com/cgi-bin/prnh/20090108/RedCrossLOGO ) , ... coughs or sneezes, and can also spread if a person ...
... , CHICAGO, Oct. 15 Americans without health insurance ... a new study. New research by the Kellogg School of ... age who experience a major health concern, such as heart ... of their household assets in order to pay their medical ...
... A new tool developed by a Medical College of ... place assisted breathing devices under difficult circumstances. About 2 ... complications regardless if it,s performed in an emergency ... physician stands behind a patient,s head and uses a metal ...
... bans are effective at reducing the risk of heart ... smoke, says a new report from the Institute of ... evidence that breathing secondhand smoke boosts nonsmokers, risk for ... relatively brief exposures could lead to a heart attack ...
Cached Medicine News:Health News:UIC study finds girls aware of HPV vaccine's benefits 2Health News:Stem Cells Grow Heart Tissue in Lab 2Health News:Stem Cells Grow Heart Tissue in Lab 3Health News:Red Cross Offers Important Tips for Caring for Someone With the Flu 2Health News:Red Cross Offers Important Tips for Caring for Someone With the Flu 3Health News:The Effects of Health on Wealth: New Study Reveals Individuals Without Health Insurance at Risk for 'Financial Catastrophe' 2Health News:The Effects of Health on Wealth: New Study Reveals Individuals Without Health Insurance at Risk for 'Financial Catastrophe' 3Health News:New laryngoscope could make difficult intubations easier 2Health News:Smoking bans reduce the risk of heart attacks associated with secondhand smoke 2
Extremely wide blade opening. Excellent bio and MRI compatibility. Lot number on each clip. Long reliable history. Large type 1/1 (mm), opening width 10.0 mm and length 12 mm....
Extremely wide blade opening. Excellent bio and MRI compatibility. Lot number on each clip. Long reliable history. Standard type 1/1 (mm), opening width 9.0 mm and length 11 mm....
Extremely wide blade opening. Excellent bio and MRI compatibility. Lot number on each clip. Long reliable history. Standard type 1/1 (mm), opening width 9.0 mm and length 8 mm....
Extremely wide blade opening. Excellent bio and MRI compatibility. Lot number on each clip. Long reliable history. Standard type 1/1 (mm), opening width 8.0 mm and length 7 mm....
Medicine Products: