Navigation Links
Aiming at Multiple Alzheimer's Proteins May be Key to Success
Date:10/21/2008

CLARKSBURG, Md., Oct. 21 /PRNewswire/ -- An independent team of scientists is leading Alzheimer's disease research in a new, promising direction. Through a $1 million grant they received last year from Alzheimer's Disease Research, a program of the American Health Assistance Foundation (AHAF), Donald F. Weaver, M.D., Ph.D. and his colleagues at Dalhousie University in Halifax, Nova Scotia, Canada are leading a multi-site, multidisciplinary international effort to design a drug that might one day prevent the onset of this devastating disease.

In Alzheimer's disease, an accumulation of beta amyloid protein "plaques" around the brain's nerve cells and tau protein "tangles" within these cells is connected to a breakdown in cell communication and eventual cell death. Evidence suggests that both beta amyloid and tau play a role, but the research community has been split on the relative effect of these two proteins on the disease process. Further, many scientists are beginning to believe that future Alzheimer's therapies will involve multiple drugs targeted at different aspects of the disease, including both of these proteins. They theorize that "misfolding" of each protein changes its shape and natural function, and contributes profoundly to the development of Alzheimer's disease. Dr. Weaver and his colleagues from Canada, the U.S., and Belgium agree that the key to successful treatment may be to halt the build-up of both beta amyloid and tau, before they begin to affect the brain's nerve cells. "Alzheimer's disease is a complex ailment and may have overlapping causes," explains Dr. Weaver. "Disrupting beta amyloid misfolding may work for some people, but not others. The same is probably true for tau. If we could control both proteins in the same patient, we might get a synergistic benefit." Rather than seeking multiple drugs to accomplish this task, Dr. Weaver's team is looking for single molecules that will bind to both proteins and possibly other Alzheime
'/>"/>

SOURCE American Health Assistance Foundation
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. The Multiple Myeloma Research Consortium (MMRC) and Proteolix Initiate Phase 2 Clinical Trial Investigating Carfilzomib for the Treatment of Multiple Myeloma
2. Millennium Initiates Clinical Trial to EVOLVE the Treatment of Patients with Newly Diagnosed Multiple Myeloma
3. Multiple Myeloma Research Consortium (MMRC) Partners with Novartis to Advance Phase II Study of Deacetylase Inhibitor
4. Kosan Opens Registration Program for Lead Hsp90 Inhibitor, Tanespimycin, in Multiple Myeloma
5. Multiple NIH Phase 2 HIV Vaccine Trials Using Vicals Technology Produce Encouraging Results
6. TorreyPines Therapeutics Initiates a Phase I Multiple Dose Clinical Trial of Tezampanel
7. Kosan Receives Completed Special Protocol Assessment for TIME-1 Pivotal Phase 3 Trial of Tanespimycin in Multiple Myeloma
8. TorreyPines Therapeutics Completes Phase I Multiple Dose Clinical Trial of NGX267, a Selective M1 Agonist for the Potential Treatment of Cognitive Impairment Associated with Schizophrenia
9. Pharmacopeia Announces Positive Results from Phase 1 Multiple Ascending Dose Study of PS433540 (DARA)
10. Phase III Clinical Trial in Newly Diagnosed Multiple Myeloma Stopped Early Due to Highly Significant Efficacy Advantage of VELCADE(R) (Bortezomib) for Injection Based Therapy Across All Endpoints
11. Velcura Therapeutics, Inc. Reports Positive Pre-IND Meeting With FDA and Plans Early Clinical Trials for New Drug to Treat Multiple Myeloma Bone Disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... 11, 2014 Neurelis, Inc. ("Neurelis") today announced ... the option held by Biotie to purchase Neurelis, clearing ... NRL-1 (intranasal diazepam) for pediatric and adult epilepsy patients ... past year, Biotie has advanced the development program for ... pivotal clinical work required for NDA submission to the ...
(Date:7/10/2014)... 10, 2014  The U.S. Department of Health and ... University Hospitals (UH) Case Medical Center Seidman Cancer Center ... aimed at improving care for patients with complex cancer. ... will test a unique model developed at UH to ... significant comorbidities, or demonstrated need for high health care ...
(Date:7/10/2014)... -- RESMED INC. (NYSE: RMD ) today announced that ... June 30, 2014 results on Thursday, July 31, 2014, after ... with ResMed,s results will be issued after 1:00 p.m. US ... discuss operating results and future outlook. The earnings ... Time and the live webcast of the call can be ...
Breaking Medicine Technology:Neurelis Regains Rights to Intranasal Diazepam Program 2Neurelis Regains Rights to Intranasal Diazepam Program 3University Hospitals Case Medical Center Awarded $4.7 Million Grant from U.S. Department of Health and Human Services 2University Hospitals Case Medical Center Awarded $4.7 Million Grant from U.S. Department of Health and Human Services 3University Hospitals Case Medical Center Awarded $4.7 Million Grant from U.S. Department of Health and Human Services 4ResMed To Announce Fourth Quarter And Fiscal Year-End 2014 Results 2
... Corporation (NASDAQ: LMNX ) today announced ... at the Defense Threat Reduction Agency,s (DTRA) 2011 ... Conference, which takes place November 14-16, 2011 in ... During the conference, Dr. Altman will present ...
... 14, 2011 HeartSine® Technologies, Inc., a world leader ... of a new global website at www.heartsine.com . ... across the globe and is committed to providing innovative, ... sudden cardiac death. HeartSine Automated ...
Cached Medicine Technology:Luminex Corporation Vice President of Biodefense to Speak at DTRA'S 2011 CBD S&T Conference 2Luminex Corporation Vice President of Biodefense to Speak at DTRA'S 2011 CBD S&T Conference 3HeartSine® Technologies Launches New Global Website 2
(Date:7/12/2014)... 2014 Doylestown Hospital recently conducted an ... men’s health questions. Paddock tackles topics including main ... women live longer than men, and testosterone replacement therapy, ... Simple featured on Doylestown Hospital’s website, Dr. Brad ... any age. If you notice pain, bulging, or asymmetry ...
(Date:7/12/2014)... 12, 2014 Dubai is buzzing with ... is heading to the UAE. The National Basketball ... be in the UAE from 28-31 October to lead ... of diabetes awareness. The event is being organized by ... event management company based in Dubai. The announcement was ...
(Date:7/12/2014)... 12, 2014 Wright & Schulte LLC, an ... Just For Men Lawsuits (case #59776/2014), announces they have ... reports that allege the popular hair dye, Just For Men, ... their face, neck and other areas. In addition to detailing ... chemical burns , the advertisements being run by Wright & ...
(Date:7/12/2014)... Maxim Peptide, a website that features ... solely in scientific experiments, is currently celebrating its second ... Maxim Peptide, which was created by the founders of ... updated website that now features a special deals section. ... with fascinating articles about peptide research, including a new ...
(Date:7/11/2014)... Recently, MagicQuinceaneraDresses.com, the popular online supplier of special occasion ... Quinceanera dresses . The company’s new items are specially ... paying a large amount of money. They are all ... The company’s online shop has become a one stop ... In addition to exquisite Quinceanera dresses, it also offers ...
Breaking Medicine News(10 mins):Health News:Ivyland Medical Center’s Dr. Brad Paddock Offers Tips for Men’s Health 2Health News:Los Angeles Basketball Legend Headed to Dubai 2Health News:Los Angeles Basketball Legend Headed to Dubai 3Health News:Just for Men Lawsuit News: TV Campaign Launched by Wright & Schulte LLC to Inform Consumers of the Alleged Association between the Popular Hair Dye and Chemical Burns 2Health News:Just for Men Lawsuit News: TV Campaign Launched by Wright & Schulte LLC to Inform Consumers of the Alleged Association between the Popular Hair Dye and Chemical Burns 3Health News:Just for Men Lawsuit News: TV Campaign Launched by Wright & Schulte LLC to Inform Consumers of the Alleged Association between the Popular Hair Dye and Chemical Burns 4Health News:Maxim Peptide Celebrates Second Anniversary Online with an Updated Website and Special Deals Section 2Health News:Cheap Quinceanera Dresses Now Available At MagicQuinceaneraDresses.com 2
... Member Adds Operations and Marketing Expertise During a Key ... Growth Period for the Association, ... announced the appointment of Susan Trainer, chief executive,officer and founder, Trainer ... at a pivotal time for the Y, which,is in the middle ...
... While urinary stents and,catheters can be life-saving medical ... infections. With 100 million placed in patients each ... device-associated infections,annually. Nerites Corporation is testing its unique ... from a $100,000 small,business innovation research grant (SBIR) ...
... NASDAQ: CRME TSX: COM, VANCOUVER and DEERFIELD, IL, ... TSX: COM) and its co-development partner,Astellas Pharma US, Inc. ... U.S. Food and Drug Administration (FDA) that a decision ... (NDA) for KYNAPID(TM),(vernakalant hydrochloride). The FDA did not provide ...
... and Drug Administration as a palliative treatment for cancer ... sometimes used off-label for the treatment of peripheral vascular ... American Journal of Therapeutics finds that off-label use of ... adverse events and device malfunctions associated with the use ...
... COVER: "The Party,s Over" (p. 22). Editor-at-Large Evan ... in a precarious state. But the party,s,candidates can ... late to reinvent,the party,s core beliefs," writes Thomas. ... humble mission: to show, in effect, some humility. ...
... million Americans, most of them women, suffer from lupus, ... bodys own tissue. This week marks a significant step ... online publication of four new studies identifying genes involved ... K.Crow, M.D., associate chief of the division of Rheumatology ...
Cached Medicine News:Health News:Mount Diablo Region YMCA Names Local Business Leader, Susan Trainer, to Its Corporate Executive Board 2Health News:Mount Diablo Region YMCA Names Local Business Leader, Susan Trainer, to Its Corporate Executive Board 3Health News:Mount Diablo Region YMCA Names Local Business Leader, Susan Trainer, to Its Corporate Executive Board 4Health News:Cardiome And Astellas Announce Regulatory Update 2Health News:Cardiome And Astellas Announce Regulatory Update 3Health News:Cardiome And Astellas Announce Regulatory Update 4Health News:Study looks at off-label use of biliary stents 2Health News:NEWSWEEK: Media Lead Sheet/January 28, 2008 Issue (on newsstands Monday, January 21). 2Health News:NEWSWEEK: Media Lead Sheet/January 28, 2008 Issue (on newsstands Monday, January 21). 3Health News:NEWSWEEK: Media Lead Sheet/January 28, 2008 Issue (on newsstands Monday, January 21). 4Health News:NEWSWEEK: Media Lead Sheet/January 28, 2008 Issue (on newsstands Monday, January 21). 5Health News:NEJM editorial on significance and limitations of new lupus gene expression research 2Health News:NEJM editorial on significance and limitations of new lupus gene expression research 3Health News:NEJM editorial on significance and limitations of new lupus gene expression research 4
... BladderScan® BVI 6100 is a handheld, noninvasive ... is easy to operate, so any staff ... To view ultrasound images from exams and ... records and reimbursement, just log on to ...
... Contigen Bard Collagen Implant, the world's ... implant option for the treatment of Stress ... bulk to surrounding urethral tissue to aid ... with the body's own structure, Contigen Bard ...
... Prosthesis,The AMS DURA II ... of cobalt-chrome alloy strands ... gives patients what they ... positioning, cosmetic concealment and ...
... advanced three-part inflatable prosthesis consisting of a reservoir ... the scrotum and a pair of cylinders inserted ... look and performance of a natural erection. The ... AMS 700 Series now features the new Tactile ...
Medicine Products: