Navigation Links
Agennix Initiates A Randomized Double-Blind, Placebo-Controlled Phase 2 Study of Oral Talactoferrin in Severe Sepsis
Date:4/22/2008

nt funding.

"The SBIR grant for sepsis, with its $3 million budget, will allow us to conduct the study with enough patients to provide an answer regarding talactoferrin's activity in the clinical setting," said Robert Lodato, M.D., Associate Professor of Medicine, University of Texas Health Science Center, and Medical Monitor for the study.

About the Phase 2 Study

The double-blind, placebo-controlled Phase 2 study of talactoferrin will enroll 190 patients who have a diagnosis of sepsis with at least one organ dysfunction due to sepsis. Patients will receive standard therapy (including, at the discretion of the primary physician, drotrecogin alfa activated, marketed as Xigris(R)(1), and will be randomly assigned (1:1) to receive either talactoferrin (1.5 g) or placebo three times a day for up to 28 days or until discharge from the intensive care unit (ICU), whichever occurs first. The primary efficacy endpoint of the trial is 28-day all-cause mortality. Secondary endpoints include number of ICU days, shock-free days, incidence and severity of organ failure/dysfunction and circulating levels of pro- inflammatory cytokines. Safety will be monitored and patients will be followed for survival at three and six months post-randomization.

About Sepsis

Sepsis is a clinical syndrome consisting of known or suspected infection and associated inflammatory response. Severe sepsis is defined as the presence of sepsis with dysfunction of one or more organs. The incidence of sepsis in the United States is estimated to be approximately 750,000 cases per year, with an annual increase of approximately 1.5%, and estimated mortality due to sepsis of 210,000 deaths each year. According to the Centers for Disease Control and Prevention, sepsis is among the top 10 leading causes of death in the United States.

Treatment for sepsis consists of eradicating the underlying infection and providing supportive care for any associated organ dysfunction. In N
'/>"/>

SOURCE Agennix, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Raptor Pharmaceuticals Corp. Initiates Phase IIa Clinical Study for Convivia(TM)
2. Romark Laboratories Initiates Phase II Study of Nitazoxanide in Treatment-Naive Patients With Chronic Hepatitis C Genotype 1
3. BrainCells Inc. Initiates Phase 2 Clinical Trial with BCI-540 for Depression with Anxiety
4. Insmed Initiates Clinical Study for Follow-on Biologic Version of Neupogen(R)
5. Schering-Plough Initiates Phase II Study With Vicriviroc in Treatment-Naive HIV-Infected Patients
6. Texas Heart(R) Institute at St. Lukes Episcopal Hospital Initiates First Clinical Trial in the World to Treat a Heart Attack Patient with a Special Stem Cell Type
7. Kosan Initiates Phase 2 Trial of Epothilone KOS-1584 in Non-Small Cell Lung Cancer
8. Arena Pharmaceuticals Initiates Phase 2b Clinical Trial of APD125 for the Treatment of Insomnia
9. Trubion Initiates Phase 1/2 Study of TRU-016 in CLL, Announces Next-Generation Product Candidate for RA and Provides Product Pipeline Update
10. Repligen Initiates Phase 3 Clinical Trial of RG1068 for Pancreatic MRI Imaging
11. Metabolex Initiates Phase 1 Trial of MBX-2982
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2014)... According to market research ... Industrial, & Laboratory), Industry (Food, Pharmaceutical, Biotechnology, Surgical ... & Geography - Global Trends & Forecast to ... lyophilization market on the basis of various types, ... the market size of each of these segments ...
(Date:9/19/2014)... ORLANDO, Fla. , Sept. 19, 2014 ... continues to grow, with the publication of two papers ... Otolaryngology – Head and Neck Surgery ... of both objective and subjective measures of sleep disordered ... therapy for the reduction in obstructive sleep apnea severity ...
(Date:9/19/2014)... and CAMBRIDGE, Mass. ... Inc. (PGDx), a provider of advanced cancer ... Medicines , a leader in discovering and developing ... today disclosed the first-ever comprehensive genomic study of ... deadly cancer of the female reproductive system, also ...
Breaking Medicine Technology:Lyophilization Market Worth $5,121.5 Million by 2019 2Lyophilization Market Worth $5,121.5 Million by 2019 3New Data shows Reductions in obstructive sleep apnea (OSA) severity and improvement of quality of life with Inspire therapy 2New Data shows Reductions in obstructive sleep apnea (OSA) severity and improvement of quality of life with Inspire therapy 3New Data shows Reductions in obstructive sleep apnea (OSA) severity and improvement of quality of life with Inspire therapy 4First Discovery Of Actionable Genetic Alterations In A Deadly Cancer Reported By Personal Genome Diagnostics And Blueprint Medicines 2First Discovery Of Actionable Genetic Alterations In A Deadly Cancer Reported By Personal Genome Diagnostics And Blueprint Medicines 3First Discovery Of Actionable Genetic Alterations In A Deadly Cancer Reported By Personal Genome Diagnostics And Blueprint Medicines 4
... Colo. , June 1 Encision Inc. (OTC ... technology that is emerging as a standard of care in ... purchasing agreement with HealthTrust Purchasing Group, LP ("HealthTrust"), effective ... are "Laparoscopic Safety Instruments – Active Electrode Monitoring Laparoscopy". , ...
... DURECT Corporation (Nasdaq: DRRX ) announced today that James E. Brown , ... Conference on Thursday, June 10 at 10:30 a.m. Eastern Time . ... .   , , , ... , , ...
Cached Medicine Technology:Encision and HealthTrust Purchasing Group Sign Purchasing Agreement 2DURECT to Present at the Jefferies Global Life Sciences Conference 2
(Date:9/21/2014)... Huntington, New York (PRWEB) September 21, 2014 ... release of their Risk Management Portal designed for ... applications with the intent to support effective risk ... is scheduled to go live coinciding with Waldorf’s ... September 21-24, 2014. , These applications were developed ...
(Date:9/21/2014)... September 21, 2014 "I wanted to ... having to consume sugary, foul-tasting energy drinks," said an ... always just want to drink plain, old coffee. That ... booster." , He developed ENERG CHEWING GUM to provide ... weight loss. The formula contains nutritious vitamins, minerals and ...
(Date:9/21/2014)... of Sparta. , Ancient Greek warriors were fed a ... of battle on distant fields. Cancer cells that metastasize ... study revealing previously unknown differences between cancer cells that ... those that travel to other organs. , Given that ... primary cause of cancer-related death, understanding how they successfully ...
(Date:9/21/2014)... 21, 2014 "I want to help ... back but haven’t the money for chiropractors," said an ... have such a product for myself." , The Stretch ... stretch the thigh muscles and align the spine properly. ... relieves discomfort of pinched nerves. Compact and easy to ...
(Date:9/21/2014)... September 21, 2014 The Electronic ... and supports electronic medical records (EMR) and electronic ... federal healthcare legislation during the past five years ... during the five years to 2019. The 2009 ... Act established Medicare and Medicaid incentives to encourage ...
Breaking Medicine News(10 mins):Health News:Waldorf Risk Solutions Releases New Risk Management Portal 2Health News:Cancer cells adapt energy needs to spread illness to other organs 2Health News:Electronic Medical Records Systems in the US Industry Market Research Report Now Available from IBISWorld 2Health News:Electronic Medical Records Systems in the US Industry Market Research Report Now Available from IBISWorld 3Health News:Electronic Medical Records Systems in the US Industry Market Research Report Now Available from IBISWorld 4
... consumption of ground beef or processed meat is positively associated ... 23 in the online journal PLoS ONE . ... University of California, San Francisco, also found that the correlation ... barbequed, especially when well done. They suggest that ...
... WEDNESDAY, Nov. 23 (HealthDay News) -- Tall or short, it,s ... person,s height. Now, scientists have found that short people actually ... them significantly smaller than average. Studying DNA from more ... learned that those of short stature -- defined roughly as ...
... Science Foundation (ESF) has awarded this year,s European Latsis ... Planck Institute for Demographic Research in Rostock, Germany. The ... was awarded the prize for his contributions to research ... demographic research. The Prize was awarded on the eve ...
... News) -- U.S. high school students still aren,t eating enough ... Centers for Disease Control and Prevention researchers. The investigators ... 12 who took part in the National Youth Physical Activity ... 1.2 times per day for both fruits and vegetables. ...
... variations in the numbers indicate that improvements are possible," says ... a study in Boston, USA, 234 million major surgical procedures ... of 25 human beings undergoes a major surgical procedure each ... also risky. According to the WHO, serious complications occur in ...
... 23 (HealthDay News) -- Huge meals and unhealthy foods, heavy ... and stroke over the holidays, an expert warns. For ... grams of fat, according to the American Council on Exercise. ... health consequences," Dr. Niten Singh, a member of the Society ...
Cached Medicine News:Health News:Gene Shortage Might Lead to Shorter Height, Study Says 2Health News:ESF awards 13th European Latsis Prize to James Vaupel on pioneering demographic research 2Health News:U.S. Teens Don't Eat Enough Fruits and Veggies: CDC 2Health News:Creating safer surgery to save more lives 2Health News:Creating safer surgery to save more lives 3
The Natural-Hip combines the surgical simplicity of a straight stem with many of the best features of an anatomic stem....
The APR Hip System offers a complete line of stems to precisely match patients' anatomic needs and address surgeon preferences....
Dual offset femoral stems, hip stems that provide unique and competitive features....
Cementless hip stem revisions offering optimal version setting for each patient. Compatible with modular link ceramic or cobalt chromium femoral heads with up to 4 neck lengths, or the link saddle de...
Medicine Products: