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Agennix Initiates A Randomized Double-Blind, Placebo-Controlled Phase 2 Study of Oral Talactoferrin in Severe Sepsis
Date:4/22/2008

n patients with severe sepsis."

Sepsis is a clinical syndrome defined by the presence of known or suspected infection and associated inflammatory response. Multi-organ damage from high levels of circulating cytokines originating from the gut is an important contributor to sepsis-induced morbidity and mortality. Talactoferrin modulates these gut-induced cytokine surges through its effects on the Gut Associated Lymphoid Tissue (GALT). In preclinical experiments, oral talactoferrin significantly reduced mortality from endotoxin- and bacterially-induced sepsis, as well as the systemic cytokine surge induced by endotoxin.

"Severe sepsis is a serious medical condition that is associated with the failure of one or more organ systems, such as cardiovascular or respiratory," said Mitchell M. Levy, M.D., Professor of Medicine, Brown Medical School, Medical Director, Medical Intensive Care Unit, Rhode Island Hospital, and an Investigator in the study. "New therapies for this disease are desperately needed. Talactoferrin is particularly exciting because of its unique mechanism of action mediated through its effect on the gastrointestinal tract and the GALT, and its potential to impact many of the abnormal pathways that contribute to sepsis-induced organ damage and associated morbidity and mortality."

About the SBIR Grant

The Small Business Innovation Research (SBIR) program of the National Institutes of Health is a set-aside program (2.5% of an agency's extramural budget) for supporting domestic small business concerns to engage in Research or Research and Development in areas that have the potential for commercialization. Some of the objectives of the SBIR Program include using small businesses to stimulate technological innovation, strengthening the role of small business in meeting Federal Research or Research and Development needs, and increasing private sector commercialization of innovations developed through Federal SBIR Research and Developme
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SOURCE Agennix, Inc.
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