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Afinitor (Breast Cancer) - Analysis and Forecasts to 2020
Date:10/20/2011

Adjuvant, First Line and Second Line 23

6.3.2 Cytotoxic Chemotherapy 25

6.3.3 Management of Patients with HER-2 Positive Patients 27

7 Afinitor 29

7.1 Introduction 29

7.2 Mechanism of Action 29

7.3 Clinical Studies 29

7.3.1 Phase I/II trial to Determine the Safety and Efficacy of everolimus (E) plus trastuzumab (T) in Patients with T-resistant Metastatic Breast Cancer 29

7.3.2 Everolimus in Combination with trastuzumab and paclitaxel in the Treatment of HER2 Positive Locally Advanced or Metastatic Breast Cancer (BOLERO-1) 30

7.3.3 Everolimus in Combination with exemestane in the Treatment of Postmenopausal Women with ER Positive Locally Advanced or Metastatic Breast Cancer who are Refractory to letrozole or anastrozole (BOLERO-2) 30

7.3.4 Daily everolimus in Combination with trastuzumab and vinorelbine in HER2 Positive women with Locally Advanced or Metastatic Breast Cancer (BOLERO-3) 30

7.4 Approval Status of Afinitor 30

7.5 Factors Affecting Sales of Afinitor 30

7.5.1 Absence of Competition from Neratinib in Japan 30

7.5.2 Patent Expiry of Aromasin before Launch of Afinitor for Breast Cancer 30

7.5.3 High Cost of Afinitor 31

7.6 Drug Risk Benefit Score 31

7.6.1 Efficacy 31

7.6.2 Safety 31

7.6.3 Compliance 31

7.6.4 Dosing Convenience 32

7.7 Intensity of Competition 32

7.8 Sales Forecasts 32

7.8.1 Target Patient Pool of Afinitor 32

7.8.2 Dosing 33

7.8.3 Market Penetration 33

7.8.4 Annual Cost of Therapy 34

7.8.5 Sales Projections of Afinitor 34

8 Appendix 44

8.1 Market Definitions 44

8.2 Abbreviations 44

8.3 Research Methodology 44

8.3.1 Coverage 44

8.3.2 Secondary Research 45

8.3.3 Forecasting 45

8.3.4 Number of Patients Approved to take the Drug 45

8.3.5 Net Penetration of Drug 46

8.3.6 Net Annual Dosing 47'/>"/>

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