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Aethlon Medical Releases Shareholder Letter
Date:11/16/2011

provide the opportunity to repurpose clinical stage affinity drugs as well as previous clinical dropouts.

On September 21st, we again leveraged the Aethlon ADAPT™ system to introduce a targeted breast cancer therapy known as HER2osome™ and enlisted clinical support from thought leaders in the cancer field.  In this application, HER2osome™ provides a therapeutic strategy to maximize the ability of the immune system and established drug therapies to combat HER2+ breast cancer, which is characterized by aggressive growth and poor prognosis resulting from the over-expression of HER2 protein.  Our therapeutic goal is to inhibit HER2+ breast cancer progression by reducing the circulatory presence of HER2 protein and tumor-secreted exosomes that contribute to the development and progression of breast cancer.

When we first initiated research into tumor-secreted exosomes, the consensus thought was that exosomes were nothing more than cellular garbage bags having no meaningful function.  Today, exosomes have emerged to become an important new therapeutic target in cancer care, yet remain unaddressed with drug therapy.  In a forthcoming disclosure, we will discuss some of our other exosome related endeavors.  However, as it relates to breast cancer, research publications indicate that breast cancer exosomes suppress the immune response, stimulate angiogenesis, contribute to the spread of metastasis, and inhibit the therapeutic benefit of Herceptin®, a leading monoclonal antibody treatment against the HER2+ breast cancer. Quite simply, we are developing HER2osome™ because we believe the resulting device will enhance the benefit of Herceptin® and standard of care chemotherapies without adding drug toxicity or interaction risks.  In this regard, the Aethlon ADAPT™ system provides a therapeutic template to immobilize both an anti-HER2 antibody and an exosome targeted affinity agent as a basis to
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SOURCE Aethlon Medical, Inc.
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Related medicine technology :

1. Aethlon Medical to Present at IN3 Medical Innovation Summit on October 27th
2. Aethlon Medical Announces Availability of its Exosome Detection Assay to the Research Community
3. Aethlon Medical Announces Hemopurifier® and HER2osome™ Cancer Therapy Presentation at Exosomes and Microvesicles 2011
4. "A Medical Device Strategy To Inhibit HER2+ Breast Cancer Progression" Released by Aethlon Medical, Inc.
5. Aethlon Medical Introduces HER2osome™, A Novel Therapeutic Device Strategy to Address Breast Cancer
6. Aethlon Medical Releases Shareholder Letter
7. Aethlon Medical to Discuss Recent Progress at the LHA Life Sciences & Medical Technologies Virtual Conference on June 16
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9. Aethlon Medical Clarifies News Report
10. ABC News Reports on Aethlon Medical
11. Aethlon Medical Announces Multi-Target Exosome Assay Validation
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