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Aethlon Medical (AEMD) Note: Multiple Shots on Goal - A Therapeutic Strategy to Address Infectious Disease & Cancer
Date:2/28/2013

targets in cancer care, and there is currently an unmet need for means of targeting these nanovesicles therapeutically.

Based on their common glycoprotein signatures, the biogenesis of virions and exosomes has been suggested to share a conserved evolutionary pathway (5).  These nano-sized particles (both in the 50-300 nm range) use their heavily glycosylated surfaces for entry into target cells, where virions and exosomes transfer pathogenic information in the form of proteins and/or genetic material.  These particles also hijack the intracellular machinery to affect cell growth and survival pathways, while also promoting the formation of more disease-mediating particles.  Indeed, newly generated virions and exosomes are both secreted by budding off from the plasma membrane of diseased cells, during which time it is believed they inherit glycoprotein-rich membrane components (6). Thus, the fields of viral and cancer immunology converge mechanistically at the level of the glycoprotein "fingerprints" on key disease-mediating particles.

The intersection of the pathways exploited by virions and exosomes is exemplified by the ability of certain viruses to package their infectious material into exosomes.  For example, HIV-infected cells secrete exosomes containing Nef or "Negative Factor", an abundant HIV protein that induces death of CD4+ T cells, a hallmark of AIDS (7).  Viruses and exosomes can therefore act as co-dependent entities for spreading infection and impeding host immunity.  A validation study conducted by our collaborators at the Morehouse School of Medicine revealed that the Hemopurifier® captures NEF exosomes and therefore holds promise as an anti-viral strategy for co-targeting both Nef exosomes and HIV virions in circulation.

Collectively, these lines of evidence provide a compelling scientific rationale for why the Hemopurifier® is a candidate broad-spectrum countermeasure against both viral p
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SOURCE Aethlon Medical, Inc.
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