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Aethlon Medical (AEMD) Note: Multiple Shots on Goal - A Therapeutic Strategy to Address Infectious Disease & Cancer
Date:2/28/2013

lycoprotein signatures associated with specific disease conditions, researchers have applied panels of carbohydrate-binding proteins (lectins) to determine the relative compositions of specific carbohydrate residues in cellular material.  Extrapolating on the use lectins as research reagents for biomarker discovery, our device platform leverages the specificity of lectins for glycoprotein-coated particles for therapeutic affinity capture.

Among the spectrum of targets of the Hemopurifier® are enveloped viruses, a broad group of infectious pathogens that are enriched for high-mannose glycoproteins on their outer surfaces.  The envelope glycoproteins have well-recognized roles in viral attachment and integration into host cells (1).  Scientific studies have demonstrated that lectins have potent anti-viral activity by virtue of their interference with the functions of envelope glycoproteins. Indeed, the current version of the Hemopurifier® has been demonstrated to capture a spectrum of enveloped viruses including HIV, Dengue virus, orthopoxviruses (vaccinia and monkeypox), influenza viruses (H5N1 bird flu, 1918 Spanish flu), and Ebola.  

In addition to addressing viral infections, the Hemopurifier also captures cancer-derived exosomes that also display high-mannose glycoproteins on their outer surfaces (2).  Exosomes are membranous nanovesicles secreted by diverse tumor types that act as inter-cellular messengers to spread oncogenic signals. Evidence is emerging that cancer exosomes are involved in practically every aspect of malignancy, including apoptosis of immune cells, tissue invasion, angiogenesis, metastases and resistance to therapeutic drugs.  The genomic and proteomic content of exosomes, as well as the exosome load in the circulation, are known to correlate with tumor stage and metastasis, suggesting that exosomes can serve as disease biomarkers (3,4).  Accordingly, exosomes have emerged as critical
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