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Aethlon Medical (AEMD) Note: Cancer Research Discovery - Melanoma Exosomes Fuel Organ Metastasis
Date:6/12/2012

SAN DIEGO, June 12, 2012 /PRNewswire/ -- Aethlon Medical, Inc. (OTCBB: AEMD), today released the following note authored by its Chairman and CEO, Jim Joyce.

(Photo: http://photos.prnewswire.com/prnh/20090325/LA88762LOGO-b)

Last week, Medical News Today reported on a cancer research discovery that reinforces the potential importance of our therapeutic endeavors.  For more than a century, cancer researchers have understood that certain forms of cancer only spread to specific, preferred organs. However, the mechanism underlying the spread of organ specific metastasis (the "soil and seed" theory of 1889) had remained unknown. Based on new findings published and now available online in the journal Nature, researchers have identified that circulating cancer-secreted particles known as "exosomes" play a significant role in fueling the metastatic invasion of preferred organs.  The paper concludes that exosomes offer promise for new therapeutic directions in the metastatic process.

We applaud and appreciate this ground breaking research as our Hemopurifier® has been validated to capture the form of cancer-secreted exosomes referenced in the publication. The same Hemopurifier® that we have been advancing with promising results in the treatment of hepatitis c (HCV) infected individuals.

In the study, researchers were interested to see if exosomes budding from melanoma actually participated in the course of the cancer. The answer was yes, and to a great extent. The researchers identified that melanoma cancer cells released "exosome" vesicles (microscopic particles like "bubbles" that are filled with many different molecules such as proteins and nucleic acids) that travel to the bone, liver, lung and brain. This cellular material fuses with targeted organs and establishes the environment to spread tumor cells.  The researchers also reported that
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