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Aethlon Medical (AEMD) Note: A Medical Device Strategy to Address Metastatic Melanoma
Date:12/7/2012

efficacy of novel immunotherapeutic solutions is limited and only small percentages of patients experience durable responses and extended survival.  Thus, the development of novel treatments to reliably bolster anti-cancer immune responses remains an urgent clinical objective.

Recent scientific studies have defined the importance of melanoma exosomes in the progression of cancer, thereby providing the rationale for targeting tumor-derived nano-vesicles therapeutically.  In a 2012 publication in the prestigious journal Nature Medicine, Dr. David Lynden's group at Weill Cornell Medical College and their colleagues reported that melanoma tumors release exosomes that condition metastatic sites for growth of tumors and their supporting blood vessels3.  This publication also identifies a correlation between high exosome concentrations in circulation with advanced disease and poor prognosis of patients. This knowledge reinforces the concept that a strategy for eliminating circulating exosomes could be beneficial for addressing metastatic disease.

A pivotal publication by Dr. Joshua Hood and colleagues at Washington University School of Medicine showed that melanoma exosomes migrate to lymph nodes and alter the biochemical milieu to allow lodging of cancer cells in the establishment of metastatic foci4.  Once again, this study suggests that systemic clearance of melanoma exosomes could interrupt the "messenger system" underlying metastasis.  Along these same lines, a study by Parolini and colleagues in The Journal of Biological Chemistry demonstrated that melanoma exosomes serve as delivery vehicles for spreading malignant proteins from high aggressive metastatic cells to less aggressive cancer cells5.This article raises the concept that exosomes from a primary tumor can transfer their cargo to distant organs, thereby allowing the malignancy to spread.

Experiments have also demonst
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SOURCE Aethlon Medical, Inc.
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