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Aethlon Medical (AEMD) Note: Extracorporeal Methods to Reduce Inflammation in Sepsis
Date:1/24/2013

e ability to selectively eliminate multiple sepsis promoting factors from circulation without disrupting the production of anti-inflammatory cytokines or other elements that might further exasperate immune suppression.  This is the focus of a strategy we are proudly advancing with industry colleagues under a contract with the Defense Advanced Research Projects Agency (DARPA).

There is also an additional factor to consider.  An increasing number of scientific journals are reporting evidence that sepsis related immune suppression reactivates latent viruses such as cytomegalovirus (CMV) and other herpes viruses in critically ill patients, which in turn can increase the severity of sepsis, lengthen the stay in the ICU and increase patient mortality rates. In one recent publication, active CMV infection was associated with an 81% higher mortality rate as compared to critically ill patients without active CMV infection.  Cytomegalovirus, or CMV, is a herpes virus found in more than half of the U.S. population over age 40. Like other herpes viruses, CMV can remain dormant inside cells for years, causing little or no apparent illness in healthy people. But in those with weakened immune systems, such as organ transplant recipients, people receiving chemotherapy, or people with AIDS, reawakening of the virus can cause serious complications or even death.

In previously conducted studies, our researchers demonstrated that our Hemopurifier® is able to capture CMV.  That's right, the same Hemopurifier® we are actively advancing in the treatment of Hepatitis C virus (HCV).   As such, we cannot ignore the possibility that our Hemopurifier® could have utility during the immunosuppressive phase of sepsis.  In Rod's presentation, he also reports evidence that the affinity agent immobilized in our Hemopurifier® to facilitate selective yet rapid clearance of circulating viral and cancer promoting targets is able to bind lip
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SOURCE Aethlon Medical, Inc.
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