Navigation Links
Aerovance Initiates Phase IIb Clinical Trial with Aerovant(TM) for the Treatment of Uncontrolled Asthma
Date:3/2/2009

BERKELEY, Calif., March 2 /PRNewswire/ -- Aerovance Inc. today announced that it has received clearance from the U.S. Food and Drug Administration (FDA) and the U.K. Medicines and Healthcare products Regulatory Agency (MHRA) to initiate Aerovance's Phase IIb clinical trial, AeroTrial(TM), of inhaled dry powder Aerovant in patients with uncontrolled asthma.

Study initiation begins today in the United States for AeroTrial, a double-blind, randomized, placebo-controlled, Phase IIb dose-ranging study. Aerovance expects to enroll approximately 500 patients with moderate to severe asthma, in the United States and Europe, who are poorly controlled by the combination of inhaled corticosteroids (ICS) and long-acting beta agonists (LABA). Patients will be randomly assigned to receive one of three Aerovant doses (1 mg, 3 mg or 10 mg) or placebo by inhalation twice daily for 12 weeks, during which time their standard ICS and LABA therapies will be gradually withdrawn. The primary endpoint is exacerbation incidence on Aerovant therapy as compared to placebo. Secondary endpoints include pulmonary function, time to exacerbation, daily peak expiratory flow (PEF) and symptom scores, immunoglobulin E (IgE) levels, and fractional concentration of expired nitric oxide (FeNO).

"Regulatory clearance and initiation of AeroTrial are significant milestones for Aerovance and potentially for patients living with uncontrolled asthma. The efficacy and safety data from our completed Aerovant studies are promising, and we are pleased to begin evaluation of this compound in a large number of moderate to severe asthmatics," said Mark Perry, Aerovance's president and chief executive officer. "Aerovant targets a root cause of asthma by blocking the signaling activity of two key cytokines, interleukin-4 (IL-4) and interleukin-13 (IL-13), critical in the progression of the disease. Our Phase IIa data suggest that targeted delivery to the lung is superior
'/>"/>

SOURCE Aerovance Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Data Show Aerovances Aerovant(TM) Inhalation Powder is Well Tolerated in Asthma Patients
2. Carrington Subsidiary DelSite Initiates Critical Toxicology Studies of Its Nasal Powder Bird Flu Vaccine
3. Romark Initiates Clinical Trial of Alinia(R) for Chronic Hepatitis C in the United States
4. Millennium Initiates Clinical Trial to EVOLVE the Treatment of Patients with Newly Diagnosed Multiple Myeloma
5. Allos Therapeutics Initiates Study of PDX in Patients with Cutaneous T-Cell Lymphoma
6. MedImmune Initiates Phase 2a Multi-Dose Study in Patients with Asthma
7. Genta Initiates Phase 3 AGENDA Trial of Genasense(R) for Patients with Advanced Melanoma
8. Nuvelo Re-Initiates SONOMA-3 Trial of Alfimeprase in Patients With Catheter Occlusion
9. TorreyPines Therapeutics Initiates a Phase I Multiple Dose Clinical Trial of Tezampanel
10. Prolexys Pharmaceuticals Initiates Phase 1 Study
11. Isis Initiates Phase 1 Study of ISIS 325568 Targeting Glucagon Receptor to Treat Type 2 Diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/17/2014)... , Sept. 17, 2014 Mindray (NYSE: ... officially released worldwide. The system has been showcased for ... during 14-17th September, and is scheduled for ... Designed to be the most efficient workhorse in ... diagnostic tools with a perfectly optimized user experience including ...
(Date:9/17/2014)... , September 17, 2014 ... to congratulate Biocartis commitment in shipping its first ... long-time investor in Biocartis as part of Debiopharm ... fully automated, real-time PCR based molecular diagnostics system, ... access to clinical molecular diagnostic information, anywhere and ...
(Date:9/16/2014)... Hologic, Inc. (NASDAQ: HOLX ... del Tomcat, un nuovo strumento preanalitico marcato CE ... automatizzata, progettata per semplificare la fase preanalitica ed ... errore legati alla gestione manuale dei campioni. ... riduce il carico di lavoro legato al trasferimento ...
Breaking Medicine Technology:Quality Exams at Your Fingertips 2Debiopharm Diagnostics Portfolio Company Biocartis Ships its First Idylla Instrument 2Hologic annuncia il lancio dello strumento preanalitico Tomcat in Europa 2Hologic annuncia il lancio dello strumento preanalitico Tomcat in Europa 3
... Par Pharmaceutical Companies, Inc. (NYSE: PRX ) will ... Friday, January 6, 2012 at the Millennium Hotel, 145 West ... Patrick G. LePore, and other members of the senior management ... current products and pipelines, and business outlook to analysts and ...
... Concord Medical Services Holdings Limited (the "Company" or "Concord ... largest network of radiotherapy and diagnostic imaging centers in ... Twelfth Annual CCM Academic Conference in Beijing on December ... conference, doctors and researchers shared their clinical and academic ...
Cached Medicine Technology:Concord Medical Completes its Twelfth Annual Academic Conference 2Concord Medical Completes its Twelfth Annual Academic Conference 3
(Date:9/17/2014)... 2014 As kids settle back ... top of mind for parents, teachers and coaches. ... about concussions and an informative video, Pediatric Concussions: ... coaches and teachers to detect, talk about and ... a pediatric orthopedic surgeon, I witness youth sports ...
(Date:9/17/2014)... 17, 2014 ICS Learning Group, Inc. ... Excellence in Training for the Best Use of Games ... on an online operational safety training module that ICS ... operation. Using an approach that combined realistic 3D ... that was similar to a video game, including competition ...
(Date:9/17/2014)... CA / MANILA, PHILIPPINES (PRWEB) September 17, 2014 ... providing Managed Operations and Business Process Outsourcing (BPO) services ... joined the firm as the Senior Vice President – ... U.S.. , Cary Weltken is a 15 year ... a wealth of experience in helping companies, ranging in ...
(Date:9/17/2014)... Freeslate, Inc. , the ... drug development, today announced that Baylor University acquired ... System to both support Baylor research interests and ... high throughput system is expected to significantly accelerate ... optimization for small molecule organic chemistry. , The ...
(Date:9/17/2014)... 17, 2014 Luxury Barber, the purveyor ... their newest addition to the Regenepure family: The Regenepure ... with nourishing and beneficial ingredients including biotin, silk proteins, ... with ample moisture, while also encouraging volume and shine. ... to complement the Regenepure DR doctor recommended ...
Breaking Medicine News(10 mins):Health News:Video Helps Kids and Adults Talk About Concussion Recognition and Treatment 2Health News:ICS Learning Group Wins Gold in the 2014 Brandon Hall Excellence Competition for Best Use of Games and Simulations for Learning 2Health News:MicroSourcing Appoints New Senior Vice President of North America 2Health News:Baylor University Selects Freeslate Reaction Screening System to Support New High Throughput Screening Lab 2Health News:Luxury Barber Adds New Regenepure Biotin Conditioner to Their Selection of Grooming Products 2
... By Steven Reinberg HealthDay Reporter , ... are getting their recommended vaccinations, federal health officials reported ... getting the shots increased 15 percent from 2008 to ... and Prevention. "This is the nation,s report card ...
... A medical researcher at the University of Leicester has made ... Dr Paul Symonds from the Department of Cancer Studies ... particular drug in collaboration with radiotherapy gives significantly better results ... of 1,412 patients from 42 different cancer treatment centres which ...
... HealthDay Reporter , THURSDAY, Aug. 19 (HealthDay News) -- ... increase your risk of dying from a stroke or heart ... for men whose blood pressure was at least 168/100, the ... than non-drinkers if they had downed six drinks on one ...
... 19, 2010The first successful report of using cell-depleted lung as ... embryonic stem cells is presented in a breakthrough article in ... by Mary Ann Liebert, Inc. ( www.liebertpub.com ). The article ... stem cells (ESCs) have the potential to mature into virtually ...
... , THURSDAY, Aug. 19 (HealthDay News) -- The economic downturn ... bank accounts aren,t the only things suffering as unemployment remains ... by Mental Health America and other researchers have found that ... for mental illness, especially such conditions as depression and anxiety. ...
... from an international study she was part of indicates ... cancer survivors are outdated. McNeely, from the Faculty ... surgery are often warned that pressure changes in an ... arm. But the study she did with an Australian ...
Cached Medicine News:Health News:More U.S. Teens Get Recommended Vaccines 2Health News:More U.S. Teens Get Recommended Vaccines 3Health News:Significant advance announced in treatment of cervical cancer 2Health News:Binge Drinking, Hypertension a Deadly Combo 2Health News:Binge Drinking, Hypertension a Deadly Combo 3Health News:Natural lung material is promising scaffold for engineering lung tissue using embryonic stem cells 2Health News:Out of Work May Mean Out of Sorts 2Health News:Out of Work May Mean Out of Sorts 3Health News:Breast cancer survivors don't need to be afraid of air travel: U of A study 2
200 L, Racked, Filtered, Pre-sterilized, 96 tips/rack Recommended for 20, 25, 50, 100 and 200 L pipettes. Can also be used with 300 L pipettes when pipetting 200 L or less....
Inquire...
... Finntip Filters are ideal for ... or for any work where ... are designed for pipetting DNA/RNA ... and other. For applications requiring ...
Inquire...
Medicine Products: