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Aeras, Crucell and South African Tuberculosis Vaccine Initiative Announce Encouraging Preliminary Results of Tuberculosis Vaccine Clinical Trial in South Africa
Date:4/9/2008

Vaccines for the World" conference. A third phase I study in healthy adults in St. Louis, Missouri, USA was launched in December 2007 and focuses on the immunogenicity and safety of two AERAS-402/Crucell Ad35 boost doses administered at three to six month intervals after BCG priming in healthy adults.

"The world urgently needs a new TB vaccine, and although we are still in the early stages of clinical trials, the preliminary data of this second phase I study are promising," said Dr. Jerald C. Sadoff, President and CEO of Aeras. "Aeras is delighted to be working with the excellent researchers at Crucell and SATVI. We are grateful to the Bill & Melinda Gates Foundation, the Netherlands Ministry of Foreign Affairs, and our other donors for their financial support of this trial and our vaccine development efforts."

This trial was conducted in the Boland-Overberg region of Western Cape Province in South Africa, which has one of the world's highest TB burdens.

"SATVI is proud to be playing such an important role in the global effort to develop new vaccines to combat TB, which are needed in South Africa and worldwide," said Dr. Gregory Hussey, Director of SATVI and Principal Investigator for the trial. "By conducting this trial, we have advanced the development of a new TB vaccine, expanded scientific capacity, and built awareness of the need for new TB vaccines."

About Tuberculosis

Tuberculosis is the world's second deadliest infectious disease, with over 9 million new cases diagnosed in 2006. According to the World Health Organization (WHO), an estimated 1.7 million people died from TB in 2006. One third of the world's population has been infected with the TB bacillus and current treatment takes 6-9 months. The current TB vaccine Bacille Calmette-Guerin (BCG), developed over 85 years ago, reduces the risk of severe forms of TB in early childhood, but is not very effective in preventing pulmonary TB in adolescents and adults - t
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SOURCE Aeras Global TB Vaccine Foundation
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