Aegerion Pharmaceuticals, Inc. Presents Final Results of Phase II Clinical Trials for AEGR-733 at Drugs Affecting Lipid Metabolism (DALM) 2007 ...(eiving ezetimibe alone experienced weigh...),Health

Date:10/4/2007

eiving ezetimibe alone experienced weight loss of about 0.2 kg; those receiving AEGR-733 monotherapy about 0.7 kg, and subjects receiving combined AEGR-733 plus ezetimibe, about 1.4 kg. The reduction in weight was statistically significant from baseline for patients receiving combination therapy. Weight loss was not significantly greater for the combination group versus ezetimibe alone and was greater in those patients with a higher baseline body mass index. A tendency toward greater effects on weight loss was consistently seen in the AEGR-733 in combination with ezetimibe than with either treatment alone.

"These trial results support the LDL-cholesterol lowering effects of AEGR-733 to clinically relevant target levels," said Jerry Wisler, Aegerion Pharmaceuticals' President and Chief Executive Officer. "In addition, there are a considerable number of patients that cannot tolerate statin therapy and have few other avenues for robust cholesterol reduction. We believe that these results demonstrate that the combination of AEGR-733 and ezetimibe could benefit this patient population. In addition, the potential for patients to lose weight may represent another benefit of the MTP-inhibitor class of compounds."

Other presentations about AEGR-733 included an oral presentation on the drug candidate's effect on single-dose pharmacokinetics of ezetimibe, and two poster presentations, one on its effects on single-dose fenofibrate (TriCor(R), Abbott) pharmacokinetics, and one on its impact on statin pharmacokinetics. These trials demonstrated that 10 mg of AEGR-733 does not result in clinically meaningful drug-drug interactions with five commonly prescribed lipid lowering compounds, opening the possibility for future trials and use of AEGR-733 with these compounds. Additionally, AEGR-733 10 mg resulted in reductions in LDL-C of 20-42% after only seven days of treatment in these 5 patient cohorts.

* Zetia(R) (ezetimibe) is a registered trademark of MSP Singapor
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SOURCE Aegerion Pharmaceuticals, Inc. Copyright©2007 PR Newswire. All rights reserved

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