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Aegera Initiates a Fifth Phase 1 and 2 Clinical Trial for AEG35156
Date:7/31/2008

t medical needs across a spectrum of cancer indications. I must also thank, once again, The Leukemia & Lymphoma Society for their financial support of this study which is the first funding granted for a clinical trial under their new Therapy Acceleration Program."

The Leukemia & Lymphoma Society Canada (LLSC) National Board Chairman, Robert Rollwagen, added, "The initiation of patient enrollment and dosing in Aegera's clinical trial marks an exciting time for lymphoma patients and LLSC. We are pleased to help accelerate the testing of a new therapeutic option for blood cancer patients and that Canadian lymphoma patients are among the first to participate in this trial."

About AEG35156

Cancer cells acquire multiple mutations that disable their normal response to apoptotic triggers. AEG35156, a second generation antisense which targets XIAP, is designed to lower the apoptotic threshold of cancer cells, enhancing their sensitivity to intrinsic death and chemotherapy, without harming healthy cells. Aegera's published data with AEG35156, both in vitro and in vivo, strongly supports this hypothesis, and validates XIAP as a novel drug target for the development of anti-cancer therapeutics.

About Aegera Therapeutics Inc.

Aegera Therapeutics is a clinical stage biotechnology company focused on developing drugs that control apoptosis to address major unmet medical needs. In addition to AEG35156, Aegera has three additional programs in clinical development for the treatment of cancer and neuropathic pain. Details of these programs can be found on Aegera's website at http://www.aegera.com.

About The Leukemia & Lymphoma Society

The Leukemia & Lymphoma Society(R), headquartered in White Plains, NY, with 68 chapters in the United States and Canada, is the world's largest voluntary health organization dedicated to funding blood cancer research and providing education and patient servi
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SOURCE Aegera Therapeutics Inc.
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