Navigation Links
Adynxx Enrolls First Patient in Phase 2 Proof-of-Concept Study for AYX1, Lead Compound for the Prevention of Post-Surgical Pain
Date:2/25/2013

SAN FRANCISCO, Feb. 25, 2013 /PRNewswire/ -- Adynxx, a clinical-stage pharmaceutical company developing a first-in-class platform of therapeutics to address pain at its molecular roots, announced today that the first patient was dosed in a Phase 2 study of its lead investigational drug candidate for the prevention of post-surgical pain, AYX1.

The 90-patient, placebo-controlled study will evaluate the safety and efficacy of a single administration of AYX1 given prior to unilateral total knee arthroplasty (TKA) to reduce acute pain and to prevent the transition to persistent pain. The study will follow patients for 42 days, with a primary endpoint of pain with walking. Secondary and exploratory endpoints will include pain at rest, pain with knee range of motion, rate and extent of functional recovery, opioid consumption and safety assessments. Further details of the study can be found at www.clinicaltrials.gov

"While many widely used pain therapies require repeat dosing for symptom amelioration, or require heavy dosing with associated side-effects to treat pain with movement, a single administration of AYX1 has the potential to block the development of pain before it begins," said Donald Manning , M.D., Ph.D., chief medical officer of Adynxx. "This study will evaluate AYX1's ability to reduce acute pain and prevent persistent pain, especially pain associated with movement, enabling patients to begin rehabilitation and resume other activities earlier."

Dennis Podlesak , chairman of the Adynxx board of directors, added, "AYX1 is a novel new treatment option that has the potential to transform how patients suffering from post-surgical pain are treated, and to provide patients and physicians with an innovative and advantageous approach to pain management.  The clinical and preclinical results to date
'/>"/>

SOURCE Adynxx
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2

Related medicine technology :

1. Lead Therapeutic Candidate for Treatment of Pain from Adynxx, AYX1, Well-Tolerated in Phase 1 Clinical Study
2. Adynxx Completes Enrollment in Phase 1 Clinical Study of Lead Therapeutic for Treatment of Pain, AYX1
3. Boehringer Ingelheim Enrolls First Patients in Pivotal Phase 3 Interferon-Free Hepatitis C Trial Program
4. CalHIPSO Enrolls Over 7,700 Providers in EHR Implementation Program, Hits Other Key Milestones After First Two Years
5. First U.S. Patients Treated in PneumRx RENEW Pivotal Study for Treatment of Severe Emphysema
6. The Emirate of Abu Dhabi Becomes First to Have JCI Accredited Long-Term Care Facility Outside of USA
7. Specialty Pharmacy Association of America (SPAARx) - Enrollment Exceeds 1,000 Members in First Two Weeks since Launch
8. Research Units Across the World go for the First 3 Tesla, Cryogen Free MRI Bench Top Scanner
9. Perrigo Confirms First to File Patent Challenge for Generic Version of Testosterone Gel 1.62%
10. Intra-Cellular Therapies Announces Completion of Phase I Single Rising Dose Trial of First-in-Class Selective Phosphodiesterase 1 (PDE1) Inhibitor and Reports Top-line Safety and Pharmacokinetic Findings
11. Smt. Sheila Dikshit Unveils South Asias First PET SUITE at Indraprastha Apollo Hospitals
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/23/2015)... , Jan. 23, 2015 A lot of discussion in ... for treating  certain illnesses, injuries, or conditions. As medical science ... treatment methods with ones that they consider to be more ... is not one textbook method of treatment that stands out ...
(Date:1/23/2015)... 23, 2015  MedScope ( www.medscope.org ), the leading provider ... 2015 Connected World magazine Connected World Award ... that can be used anywhere, anytime. The nomination was ... In nominating MedScope, Landon Garner , Director ...
(Date:1/23/2015)... Jan. 23, 2015  HyGreen, Inc., a leader in hand ... with RCA Medical, a subsidiary of Ascendis Health Limited, ... Each year, hundreds of millions of patients around ... organisms are transmitted from patient to patient via the ...
Breaking Medicine Technology:No One-Size-Fits-All Remedy for Hernia Correction 2MedScope Nominated by RacoWireless for Prestigious 2015 Connected World Magazine Connected World Award 2HyGreen Partners with RCA Medical in Johannesburg, South Africa 2
... update regarding the voluntary recall of AVEA® ventilators it initiated ... a Class I recall. There is no ... and CareFusion is actively remediating the hardware on affected units. ... March 1, 2009 and June 30, 2011 and therefore has ...
... Mass., Dec. 22, 2011  Inspiration Biopharmaceuticals, Inc. (Inspiration), ... development and commercialization of new treatment options for ... has expanded its leadership team with four key ... as Chief Medical Officer; Daniel Regan as Chief ...
Cached Medicine Technology:CareFusion Provides Update on Previously Announced Ventilator Recall 2Inspiration Biopharmaceuticals Expands Leadership Team with Four New Hires 2Inspiration Biopharmaceuticals Expands Leadership Team with Four New Hires 3Inspiration Biopharmaceuticals Expands Leadership Team with Four New Hires 4Inspiration Biopharmaceuticals Expands Leadership Team with Four New Hires 5
(Date:1/22/2015)... January 22, 2015 The federal court overseeing ... U.S. District Court, Southern District of West Virginia has upheld ... that proceeding’s first bellwether trial. In an Order dated January ... trial after finding that C.R. Bard had not proven a ...
(Date:1/22/2015)... over 20 years, Dr. David Cruz of Cruz Chiropractic Care ... just about every type of injury that can result from car ... twenty-plus years, the team at Doctors on Liens has ... doctor. With the combined breadth of experience between the ...
(Date:1/22/2015)... 2015 Recently, Weddingshe.com has added many trendy ... announced its highest annual revenues in the past three years. ... glamorous wedding dresses. , According to the sales manager of ... promotions for them in 2015. This point can be reflected ...
(Date:1/22/2015)... New York, NY (PRWEB) January 22, 2015 ... component of overall health care gains momentum worldwide, Rev. ... York-based HealthCare Chaplaincy Network (HCCN), will be the ... advance spiritual care in Israel’s public health system. , The ...
(Date:1/22/2015)... State Forestry Institute of Mecklenburg-Vorpommern in Germany ... from GEOSYSTEMS, a dedicated Hexagon Geospatial and Intergraph partner ... Geospatial’s ERDAS APOLLO for cataloging, managing, and ... clouds and documents. This effort will enable the State ...
Breaking Medicine News(10 mins):Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 2Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 3Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 4Health News:Industry Leading Chiropractor in Oceanside Joins the Doctors on Liens Network 2Health News:Weddingshe Announces A Special Offer On Its Popular Glamorous Wedding Dresses 2Health News:HealthCare Chaplaincy CEO to Keynote Spiritual Care Summit in Israel 2Health News:HealthCare Chaplaincy CEO to Keynote Spiritual Care Summit in Israel 3Health News:State Forestry Institute Mecklenburg-Vorpommern, Germany Embraces Hexagon Geospatial Technology 2Health News:State Forestry Institute Mecklenburg-Vorpommern, Germany Embraces Hexagon Geospatial Technology 3
... , NASHVILLE, Tenn., Nov. 2 Brookdale Senior Living Inc. ... operating results for the third quarter of 2009. ... our strong results this quarter which build on the success ... platform is operating effectively in today,s difficult environment as evidenced ...
... Group, Inc. (Nasdaq: ENSG ), the parent company of ... care and assisted living companies, today reported record results for ... http://www.newscom.com/cgi-bin/prnh/20071213/LATH168LOGO ) , Financial Highlights for ... a record $132.9 million, up 14.3% compared to $116.3 million ...
... Early-stage breast cancer patients with HER2 positive tumors one centimeter ... disease, compared to those with early-stage disease who do not ... researchers at The University of Texas M. D. Anderson Cancer ... Journal of Clinical Oncology , is the first large study ...
... talk also changes the way speech sounds are heard, ... of the National Academy of Sciences by scientists ... could have a major impact on improving speech disorders. ... motor function affects sensory processing and vice-versa," said David ...
... the prostate and nearby organs in every brachytherapy procedure ... and uniformly documented in every patient, according to a ... Medical Physics in the department of Radiation Oncology at ... a task group commissioned by the American Association of ...
... ... Congress, Americans are anxious to see how the government will respond to ... in medicine on the horizon, nearly 1.5 million citizens have taken matters ... which announced this week the loss of its 5 millionth pound – ...
Cached Medicine News:Health News:Brookdale Announces Third Quarter 2009 Results; CFFO per Share Increases 43% 2Health News:Brookdale Announces Third Quarter 2009 Results; CFFO per Share Increases 43% 3Health News:Brookdale Announces Third Quarter 2009 Results; CFFO per Share Increases 43% 4Health News:Brookdale Announces Third Quarter 2009 Results; CFFO per Share Increases 43% 5Health News:Brookdale Announces Third Quarter 2009 Results; CFFO per Share Increases 43% 6Health News:Brookdale Announces Third Quarter 2009 Results; CFFO per Share Increases 43% 7Health News:Brookdale Announces Third Quarter 2009 Results; CFFO per Share Increases 43% 8Health News:Brookdale Announces Third Quarter 2009 Results; CFFO per Share Increases 43% 9Health News:Brookdale Announces Third Quarter 2009 Results; CFFO per Share Increases 43% 10Health News:Brookdale Announces Third Quarter 2009 Results; CFFO per Share Increases 43% 11Health News:Brookdale Announces Third Quarter 2009 Results; CFFO per Share Increases 43% 12Health News:Brookdale Announces Third Quarter 2009 Results; CFFO per Share Increases 43% 13Health News:Brookdale Announces Third Quarter 2009 Results; CFFO per Share Increases 43% 14Health News:Brookdale Announces Third Quarter 2009 Results; CFFO per Share Increases 43% 15Health News:Brookdale Announces Third Quarter 2009 Results; CFFO per Share Increases 43% 16Health News:Brookdale Announces Third Quarter 2009 Results; CFFO per Share Increases 43% 17Health News:Brookdale Announces Third Quarter 2009 Results; CFFO per Share Increases 43% 18Health News:Brookdale Announces Third Quarter 2009 Results; CFFO per Share Increases 43% 19Health News:Brookdale Announces Third Quarter 2009 Results; CFFO per Share Increases 43% 20Health News:Brookdale Announces Third Quarter 2009 Results; CFFO per Share Increases 43% 21Health News:Brookdale Announces Third Quarter 2009 Results; CFFO per Share Increases 43% 22Health News:Brookdale Announces Third Quarter 2009 Results; CFFO per Share Increases 43% 23Health News:The Ensign Group Reports Third Quarter 2009 Adjusted Earnings of $0.38 per Share 2Health News:The Ensign Group Reports Third Quarter 2009 Adjusted Earnings of $0.38 per Share 3Health News:The Ensign Group Reports Third Quarter 2009 Adjusted Earnings of $0.38 per Share 4Health News:The Ensign Group Reports Third Quarter 2009 Adjusted Earnings of $0.38 per Share 5Health News:The Ensign Group Reports Third Quarter 2009 Adjusted Earnings of $0.38 per Share 6Health News:The Ensign Group Reports Third Quarter 2009 Adjusted Earnings of $0.38 per Share 7Health News:The Ensign Group Reports Third Quarter 2009 Adjusted Earnings of $0.38 per Share 8Health News:The Ensign Group Reports Third Quarter 2009 Adjusted Earnings of $0.38 per Share 9Health News:The Ensign Group Reports Third Quarter 2009 Adjusted Earnings of $0.38 per Share 10Health News:The Ensign Group Reports Third Quarter 2009 Adjusted Earnings of $0.38 per Share 11Health News:The Ensign Group Reports Third Quarter 2009 Adjusted Earnings of $0.38 per Share 12Health News:The Ensign Group Reports Third Quarter 2009 Adjusted Earnings of $0.38 per Share 13Health News:The Ensign Group Reports Third Quarter 2009 Adjusted Earnings of $0.38 per Share 14
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: