Navigation Links
Adynxx Completes Patient Enrollment in Phase 2 Clinical Study of Lead Therapeutic for Prevention of Pain, AYX1
Date:9/5/2013

SAN FRANCISCO, Sept. 5, 2013 /PRNewswire/ -- Adynxx, a clinical-stage pharmaceutical company developing a transformative, first-in-class platform of therapeutics to address pain at its molecular roots, announced today the completion of enrollment in a Phase 2 clinical study of its lead product candidate, AYX1, for reduction of acute post-surgical pain and prevention of the transition to persistent or chronic pain with a single administration at the time of surgery.  The U.S. Food and Drug Administration (FDA) granted Fast Track designation to AYX1 Injection for the prevention of chronic pain in July 2013.

The 102-subject, seven-center, randomized, placebo-controlled study is currently evaluating the safety and efficacy of a single intrathecal administration of AYX1 given prior to unilateral total knee arthroplasty (TKA) to reduce acute pain and to prevent the transition to persistent pain. The study is following subjects for 42 days, with a primary endpoint of pain with walking. Secondary and exploratory endpoints include pain at rest, pain with knee range of motion, rate and extent of functional recovery, opioid consumption and safety assessments. Further details of the study can be found at www.clinicaltrials.gov using the identifier NCT01731730.

"We believe AYX1 has the potential to revolutionize the treatment of post-surgical pain, and we are pleased to have efficiently and successfully completed enrollment in this Phase 2 study," said Donald Manning, M.D., Ph.D., chief medical officer of Adynxx. "With enrollment complete, we look forward to receiving and evaluating the study data in the next quarter and continuing to advance through development."

Dennis Podlesak, chairman of the Adynxx board of directors, added, "As evidenced by the recent Fast Track designation of AYX1, this treatment could potentially provide physicians with a transformative new option for pain management. The rapid progress made by the Adynxx team brings AYX1 one step closer to meeting the needs of millions of patients who every year suffer from pain after surgery."

About Adynxx

Adynxx, located in San Francisco, California, is a clinical-stage pharmaceutical company developing a transformative technology platform addressing pain at its molecular roots - preventing the development of pain following surgery or trauma and resolving established chronic pain syndromes.  Adynxx's unique approach is to transform pain management by approaching pain as a disease rather than a symptom.

Adynxx's lead compound, AYX1, is an investigational drug designed to reduce acute post-surgical pain and prevent the transition to persistent or chronic pain with a single administration at the time of surgery. 

Funded by Domain Associates, Adynxx has successfully completed a Phase 1 clinical study of AYX1 and completed enrollment in a Phase 2 study of AYX1 in Q3 2013.  Additional compounds targeting a range of intractable neuropathic and inflammatory pain syndromes are in the pre-clinical discovery stage.

Media Contact:

David Schull or Ian Stone
Russo Partners
(858) 717-2310
(619) 308-6541
david.schull@russopartnersllc.com
ian.stone@russopartnersllc.com


'/>"/>
SOURCE Adynxx
Copyright©2012 PR Newswire.
All rights reserved

Related medicine technology :

1. Adynxx Enrolls First Patient in Phase 2 Proof-of-Concept Study for AYX1, Lead Compound for the Prevention of Post-Surgical Pain
2. Lead Therapeutic Candidate for Treatment of Pain from Adynxx, AYX1, Well-Tolerated in Phase 1 Clinical Study
3. Adynxx Completes Enrollment in Phase 1 Clinical Study of Lead Therapeutic for Treatment of Pain, AYX1
4. Otonomy Completes $45.9 Million Series C Equity Financing
5. BioReliance Opens New U.S. Clearance Services Laboratories; Completes Global Facility Upgrade Plan
6. SERVE-HF; the Worlds Largest Study of Sleep-Disordered Breathing in Heart Failure Completes Recruitment
7. OPKO Completes Acquisition Of PROLOR Biotech
8. Sleep Nation, Inc. Completes 43 Acquisitions
9. Arena Pharmaceuticals Completes Phase 1b Clinical Trial Evaluating APD811 for Pulmonary Arterial Hypertension
10. InspireMD Completes First Phase of Manufacturing Upgrade and Partners with HealthLink for Global Logistics and Distribution Services
11. Immune Pharmaceuticals Completes Merger with EpiCept Corporation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/20/2016)... According to the 2016 home healthcare ... for affordable healthcare solutions as since the early 2000s, the ... countries like the US, the healthcare cost rose faster than ... price index inflation rate stood at an average of 2.04% ... 3.62% during the same time period. This can be attributed ...
(Date:5/19/2016)... Boehringer Ingelheim Pharmaceuticals, Inc. (BIPI) announced today that it is ... a chance to meet iconic entertainer Mario Kreutzberger ... past two years has been the face of the company,s ... with type 2 diabetes, which Don Francisco is ... and tips for long-term healthy lifestyle choices. ...
(Date:5/19/2016)... , The data will be presented in ...   The conclusions of the study point to ... with 90% of the m presenting duration ... percent of the patients had clinical benefit.   ... I study of plitidepsin in combination with bortezomib and dexamethasone in patients with ...
Breaking Medicine Technology:
(Date:5/24/2016)... (PRWEB) , ... May 24, 2016 , ... ... trip to the Dominican Republic on September 21, 2016. Dr. Gerard, who holds ... serves with ChiroMission, a not-for-profit organization promoting health and wellness in Third World ...
(Date:5/24/2016)... Milwaukee, WI (PRWEB) , ... May 24, 2016 ... ... Facility In Milwaukee , Out patient Services To Begin In June , Aloria ... is pleased to announce the opening of Aloria Milwaukee, its first treatment facility ...
(Date:5/24/2016)... (PRWEB) , ... May 24, 2016 , ... "ProText Layouts ... said Christina Austin - CEO of Pixel Film Studios. , ProText Layouts Vol. 3 ... Final Cut Pro X . With ProText Layouts, video editors can create an ...
(Date:5/24/2016)... (PRWEB) , ... May 24, 2016 , ... The old ... causing the problem. A common injury that’s often misunderstood, whiplash should be swiftly diagnosed ... a Harvard-trained, orthopedic spine surgeon at Atlantic Spine Center . , So ...
(Date:5/24/2016)... ... May 24, 2016 , ... Since 1946, the doctors ... care. From the moment a patient arrives at the office, the staff will ... with each and every patient to create a complete dental treatment plan that is ...
Breaking Medicine News(10 mins):