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Advanced Life Sciences' Restanza Shows 100% Survival in Tularemia Pivotal Animal Study
Date:12/16/2009

CHICAGO, Dec. 16 /PRNewswire-FirstCall/ -- Advanced Life Sciences Holdings, Inc. (OTC Bulletin Board: ADLS), today announced positive top-line results from a pivotal, non-human primate study of its novel, once-a-day, oral antibiotic Restanza(TM) (cethromycin) against an inhaled lethal dose of tularemia. A 14-day course of Restanza achieved a 100% survival rate at the doses tested. All of the ten animals in the study that received 16 mg/kg once-a-day of Restanza (approximate to a human dose of 300 mg) within 24 hours after exposure to a lethal dose of inhaled tularemia survived while only one of the ten animals that received placebo survived.

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"We believe that the impressive survival data in tularemia, combined with previously reported survival data in anthrax and plague, confirm the profile of Restanza as a potent, broad spectrum medical countermeasure for biodefense and underscore Restanza's impressive efficacy and safety against lethal pathogens which could represent significant threats to public health and safety," said Michael T. Flavin, Ph.D., chairman and chief executive officer of Advanced Life Sciences. "We believe that our company's biodefense strategy represents a promising commercial opportunity and we are excited about the scope and pace of our progress to date. One of Restanza's major differentiating advantages, and a key characteristic that has attracted US government interest, is its demonstrated breadth of activity against many lethal pathogens."

Tularemia is a bacterial disease commonly transmitted to humans through contact with infected rodents or rabbits or through insects that carry Francisella( )tularensis, the causative agent of tularemia, which is classified by the Cen
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SOURCE Advanced Life Sciences Holdings, Inc.
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