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Adlyfe Study on the Detection of Misfolded Proteins Published in the Journal Transfusion
Date:8/29/2007

Misfolded Protein Diagnostic (MPD) Shown to be Sensitive and Specific Technology Applicable for the Detection of a Host of Amyloid Neurological

Diseases including Creutzfeldt-Jakob Disease (CJD), Alzheimer's, and

Parkinson Disease

ROCKVILLE, Md., Aug. 29 /PRNewswire/ -- Adlyfe, a private company developing novel diagnostic testing technologies for early targets of amyloid diseases, announced today the publication of a study, "Detection of misfolded prion protein in blood with conformationally sensitive peptides," in the August 2007 issue of the journal Transfusion. The monthly publication is the official peer-reviewed journal of the AABB, formerly known as the American Association of Blood Banks.

The published study examined the ability of Adlyfe's Misfolded Protein Diagnostic (MPD) to detect the presence of misfolded proteins in brain, serum and plasma. Study results demonstrated that Adlyfe's MPD assay is a sensitive and specific test for the detection misfolded prion proteins that may be useful in both preclinical and clinical diagnosis transmissible spongiform encephalopathy (TSE) diseases in both animals and humans.

Scientists have tried to develop a preclinical diagnostic test for TSE since the discovery that humans with variant Creutzfeldt-Jakob disease can transmit disease via blood transfusions, though there are several challenges to detecting misfolded proteins in the blood. The coexistence of a large amount of the protein in its normally folded shape and the fact that misfolded proteins do not trigger an immune system response that would enable diagnosis based on the detection of antibodies. In addition, most standard detection methods are not sensitive enough to detect the low level of misfolded proteins in the blood, especially during early disease stages. These challenges have largely restricted diagnostic tests for amyloid diseases to the use of postmortem tissue.

Adlyfe's novel tech
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