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Adeona's Clinical Study of reaZin™ Meets Primary Outcomes of Increasing Serum Zinc and Decreasing Serum Free Copper
Date:4/14/2011

efore the start of the call to register and identify themselves as registrants of the 'Adeona' Conference Call. Any registered caller on the toll free line may ask to be placed in the queue for the Question & Answer session. The call will be simulcast on the web at http://www.videonewswire.com/event.asp?id=78671. If you are unable to participate during the live call, the webcast will be available for replay at www.adeonapharma.com for 30 days after the call.

About reaZin Clinical Study

Two scientific observations support Adeona's hypothesis that correcting zinc and free copper abnormalities could benefit AD patients as measured by cognitive scores. The first observation is derived from studies conducted by Dr. Squitti and her group that have shown the following: 1) AD patients have elevated levels of serum free copper(2) and 2) the elevated levels of free copper correlate with lower cognitive function(3) and, over time, a decline in cognitive function(4). The second observation is the finding that AD patients are zinc deficient compared to age-matched control patients(5). These findings suggest that elevated free copper is toxic to the brain of AD patients. Therefore, based on these scientific observations, Adeona's therapeutic strategy for the reaZin clinical study is to correct zinc deficiency and to lower serum free copper in AD patients. Based on findings in Wilson's disease (a disease characterized by toxic levels of free copper), oral zinc is known to lower serum free copper.

The prospective, randomized, double-blind, placebo-controlled clinical study represents the first controlled clinical study evaluating the safety and efficacy of a zinc and cysteine-based therapy (reaZin) for Alzheimer's disease. Study subjects were randomized into the active treatment group or the placebo group and wer
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SOURCE Adeona Pharmaceuticals, Inc.
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