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Adeona's Clinical Study of reaZin™ Meets Primary Outcomes of Increasing Serum Zinc and Decreasing Serum Free Copper
Date:4/14/2011

ANN ARBOR, Mich., April 14, 2011 /PRNewswire/ -- Adeona Pharmaceuticals, Inc. (AMEX: AEN), a developer of innovative medicines for serious central nervous system diseases, announced today top-line results from its clinical study evaluating reaZin for the dietary management of Alzheimer's disease (AD) and mild cognitive impairment (MCI). The clinical study met the primary outcome of increasing serum zinc and decreasing serum free copper. In addition, secondary outcomes of mental status as measured by three standardized cognitive tests all favored the treatment group versus the placebo group.

The clinical study data was presented today at the Annual Meeting of the American Academy of Neurology (AAN) in Honolulu, Hawaii at 2:00 p.m. (HAST)/8:00 p.m. (EDT) by Diana Pollock, M.D., Lead Principal Investigator of the study at Morton Plant Neuroscience Institute on the campus of Morton Plant Hospital. The poster titled "Clinical Trial Results of the First Controlled Clinical Trial of Zinc-Based Therapy for Alzheimer's Disease and Mild Cognitive Impairment" included findings from 42 of 57 subjects evaluable at the end of the study.  The results are as follows:

  • The treatment group showed significant reductions in serum free copper levels and elevations in serum zinc levels over the placebo group, resulting in a highly statistically significant change in the free copper to zinc ratio (-20.8%), the primary outcome of the clinical study (p < 0.0006).
    • An average net decrease in serum free copper of -6.5 microg/dL for the treatment group versus placebo group.
    • An average net increase in serum zinc of 64.6 microg/dL for the treatment group versus the placebo group.

  • Comparisons of the average changes in cognitive scores at base
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SOURCE Adeona Pharmaceuticals, Inc.
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