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Adeona Executes Agreement to Initiate Phase IIb Clinical Trial of Proprietary Zinc-Based Therapy in Lou Gehrig's Disease (ALS)
Date:6/23/2011

improve the quality of life of patients with neurological diseases, such as ALS. As observed in other central nervous system diseases, the biological availability of zinc is impaired in ALS patients. We hypothesize that by giving high doses of zinc to ALS patients, we can decrease the amount of toxicity from unbound glutamate and prevent neurotoxicity," said Todd D. Levine, M.D., President of PNA Center for Neurological Research, Assistant Clinical Professor at the University of Arizona, Co-Director of the Banner Samaritan ALS Center in Phoenix, Arizona and Lead Principal Investigator of the planned clinical trial. "We are pleased to be working with Adeona and utilizing their proprietary zinc-based therapy that has already demonstrated clinical evidence of being very well tolerated by patients with superior bioavailability."

"Adeona's mission is to develop innovative medicines for serious central nervous system diseases. Expanding our pipeline to include ALS, a devastating and fatal neurological disease for which there is a shortfall of treatment options, is an ideal fit with our expertise and business model," said James S. Kuo, M.D., M.B.A., Chief Executive Officer of Adeona. "Given the body of scientific evidence suggesting a therapeutic role for zinc in ALS, we look forward to the start of dosing ALS patients in this Phase IIb clinical trial to be conducted under an IND. We are pleased to be working with the dedicated neurologists at Phoenix Neurological Associates."

About Amyotrophic Lateral Sclerosis (ALS)

ALS is a devastating progressive neurodegenerative disease that affects the nerve cells in the brain and the spinal cord in people of all ages and both sexes. It is estimated that as many as 30,000 Americans may have the disease at any given time. The progressive degeneration of the motor neurons in ALS eventually leads to the death of the patient. Motor neurons reach from the brain to the spinal cord and from the spinal cord to th
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SOURCE Adeona Pharmaceuticals, Inc.
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