Navigation Links
Adeona Announces Completion of Planned Enrollment in Phase II Multiple Sclerosis Clinical Trial
Date:9/19/2011

g from this devastating disease," stated James S. Kuo, M.D., M.B.A., Adeona's Chairman and CEO. "Once all of the patients have been enrolled and dosed for two years, we look forward to announcing Dr. Voskuhl's top-line results, and if positive, we would expect to seek FDA guidance on filing a New Drug Application."

About Trimesta (oral estriol)

Trimesta (oral estriol) is Adeona's proprietary drug candidate for the treatment of relapsing-remitting MS in women. Estriol has been approved and marketed for over 40 years throughout Europe and Asia for the treatment of post-menopausal hot flashes. It has never been approved by the FDA for any indication in the United States.

It has been scientifically documented that pregnant women with certain autoimmune diseases experience a spontaneous reduction of disease symptoms during pregnancy, particularly in the third trimester. The PRIMS (Pregnancy In Multiple Sclerosis) study, a landmark clinical study published in the New England Journal of Medicine followed 254 women with MS during 269 pregnancies, and for up to one year after delivery. The PRIMS study demonstrated that relapse rates were significantly reduced by 71 percent (p < 0.001) through the third trimester of pregnancy compared to pre-pregnancy-rates, and that relapse rates increased by 120 percent (p < 0.001) during the first three months after birth (post-partum) before returning to pre-pregnancy rates.

It has been hypothesized that the female hormone, estriol, produced by the placenta during pregnancy, plays a role in "fetal immune privilege," a process that prevents a mother's immune system from attacking and rejecting her fetus. Maternal levels of estriol increase in a linear fashion through the third trimester of pregnancy until birth, whereupon they abruptly return to low circulating levels. The anti-autoimmune effects of estriol may also be responsible for the beneficial effects of pregnancy on MS.<
'/>"/>

SOURCE Adeona Pharmaceuticals, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Adeona Appoints George A. Eby to Scientific Advisory Board
2. Adeona Reports Second Quarter 2011 Financial Results
3. Adeona to Host Second Quarter 2011 Investor Conference Call
4. Adeona Executes Agreement to Initiate Phase IIb Clinical Trial of Proprietary Zinc-Based Therapy in Lou Gehrigs Disease (ALS)
5. Adeona Reports 1st Quarter 2011 Financial Results
6. Adeona to Host First Quarter 2011 Investor Conference Call
7. Adeona Executes Manufacturing and Supply Agreement with TG United for reaZin™
8. Adeonas Clinical Study of reaZin™ Meets Primary Outcomes of Increasing Serum Zinc and Decreasing Serum Free Copper
9. Adeona to Host Conference Call
10. Adeona to Raise $3.5 Million in Registered Direct Offering
11. Adeona Reports 2010 Year End Financial Results
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... 17, 2014  RXi Pharmaceuticals Corporation (NASDAQ: ... discovering, developing and commercializing innovative therapies addressing major ... of enrollment in its first Phase 2a study, ... confirmed the 1-month findings that were reported in ... - http://photos.prnewswire.com/prnh/20130917/NE80755LOGO , , ...
(Date:12/17/2014)... HOUSTON , Dec. 17, 2014 ... Autism Approved ( http://bit.ly/1382OkS ) program seal ... autism community. The program highlights medical practices, materials ... considered "autism-community friendly." Children affected by ... that can be exacerbated by ingredients found in ...
(Date:12/15/2014)... , Dec. 12, 2014 Research and Markets ... addition of the "MEMS Gyroscopes Analog Devices ... report to their offering. ... for tactical grade applications made a lot of ... of reliability. They are now accepted in high-reliability ...
Breaking Medicine Technology:RXi Pharmaceuticals Announces Sustained Effect of RXI-109 at Three Months Post Scar Revision Surgery and the Completion of Enrollment for its Phase 2a Trial RXI-109-1301 2RXi Pharmaceuticals Announces Sustained Effect of RXI-109 at Three Months Post Scar Revision Surgery and the Completion of Enrollment for its Phase 2a Trial RXI-109-1301 3RXi Pharmaceuticals Announces Sustained Effect of RXI-109 at Three Months Post Scar Revision Surgery and the Completion of Enrollment for its Phase 2a Trial RXI-109-1301 4RXi Pharmaceuticals Announces Sustained Effect of RXI-109 at Three Months Post Scar Revision Surgery and the Completion of Enrollment for its Phase 2a Trial RXI-109-1301 5Parents Of Children With Autism Spectrum Disorder Have New Options When Administering Medications 2Parents Of Children With Autism Spectrum Disorder Have New Options When Administering Medications 3MEMS Gyroscopes Analog Devices ADIS16136 Precision Angular Rate Sensor Reverse Costing Analysis 2
(Date:12/19/2014)... Being in good shape seems to reduce your risk of ... from more than 57,000 Americans, including more than 35,000 with ... 2009. Those in the poorest shape had a more ... the start of the study, compared to a 50 percent ... the more than 8,000 people diagnosed with high blood pressure ...
(Date:12/19/2014)... -- The tragic death from "rat-bite fever" of a 10-year-old ... rodents, according to a report from the U.S. Centers for ... but potentially fatal illness that should be considered in persons ... of rodent exposure is reported," said a team led by ... The case outlined in the report occurred in August of ...
(Date:12/19/2014)... Dotinga HealthDay Reporter ... including ibuprofen, might slightly reduce your risk of developing ... of ibuprofen (Advil, Motrin) and naproxen (Aleve) appear to ... 15 percent, the researchers concluded after reviewing nine prior ... sun exposure. These painkillers "have potential ...
(Date:12/19/2014)... Prostaglandin analogue eye drops -- a common form of ... loss in patients with the eye disease, a new ... of the Moorfields Eye Hospital and UCL Institute of ... people newly diagnosed with open-angle glaucoma -- the most ... leading causes of blindness. About 45 million people ...
(Date:12/17/2014)... Lauderdale, FL (PRWEB) December 17, 2014 While ... many people do not realize the potential dangers of their ... a valid prescription from a qualified doctor, but patients who ... to the point that there is actually no real hCG ... United States, where there are no safety standards and may ...
Breaking Medicine News(10 mins):Health News:Being Fit Keeps Blood Pressure in Check 2Health News:Scratch From Pet Rat Kills Child; CDC Warns of Risk 2Health News:Common Painkillers May Help Prevent Certain Skin Cancers, Study Finds 2Health News:Common Painkillers May Help Prevent Certain Skin Cancers, Study Finds 3Health News:Study Supports Benefit of Widely Used Glaucoma Drug 2Health News:Diet Doc Reveals the Real Dangers for Those who Buy hCG Online 2Health News:Diet Doc Reveals the Real Dangers for Those who Buy hCG Online 3
... HealthDay Reporter , THURSDAY, Feb. 16 (HealthDay ... struggle with heart failure, experts say new treatments have ... for these patients. "The present environment for heart ... that will truly remove the term ,failure, from the ...
... Hall Institute scientists have revealed new details about ... system, identifying in the process potential new therapeutic ... Jeff Babon and Professor Nick Nicola, from the ... respectively, study interactions between internal cell signalling proteins ...
... fracture easily. It is a major complication of spinal cord ... A new clinical trial conducted by University of Iowa researchers ... bone through programmed electrical stimulation of the muscle significantly slows ... The focus on quantifying the effective dose of load is ...
... -- In an effort to reduce and eventually eliminate cancer ... Cancer Center at Jefferson has established the Center ... Mitchell, M.D., FACP , a medical oncologist at Thomas ... Medical Oncology in the Department of Medical Oncology at Jefferson ...
... Reporter , THURSDAY, Feb. 16 (HealthDay News) -- A sweetener ... of arsenic, new research suggests. Researchers at Dartmouth College ... found in some infant formulas. Their report appears in the ... Arsenic is a natural element that can contaminate groundwater. As ...
... a free, non-promotional online program designed to support ... chronic pain. This study tested painACTION.com,s ability to ... with chronic migraine headaches. A total of 185 ... were more confident that they could prevent headaches ...
Cached Medicine News:Health News:Treatment Advances Improve the Odds for Heart Failure Patients 2Health News:Treatment Advances Improve the Odds for Heart Failure Patients 3Health News:Cell signaling discovery provides new hope for blood disorders 2Health News:High doses of 'load' slows loss of bone in spinal cord injury 2Health News:High doses of 'load' slows loss of bone in spinal cord injury 3Health News:Jefferson's Kimmel Cancer Center establishes Center to Eliminate Cancer Disparities 2Health News:Jefferson's Kimmel Cancer Center establishes Center to Eliminate Cancer Disparities 3Health News:Arsenic Might Be Found in Some Organic Foods: Study 2Health News:Arsenic Might Be Found in Some Organic Foods: Study 3Health News:painACTION.com improves migraine self-management and reduces migraine-related psychological distress 2
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: