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Adeona Acquires Access to Clinical Data Supporting Oral Zinc for Prevention of Infections in the Elderly
Date:12/16/2010

ted group) (p less than 0.001).(1)

Adeona's Portfolio of Zinc-Based Therapies for Diseases in the Elderly

Adeona is developing a portfolio of proprietary oral zinc-based therapies that is expected to offer superior benefits including improved convenience, bioavailability and gastrointestinal tolerability for major diseases of the elderly. The Company considers zinc deficiency of the elderly to be a major public health issue, with zinc deficiency implicated in age-related macular degeneration, Alzheimer's disease, complications of diabetes mellitus and impaired immune function.(2) Declines in serum zinc levels and impaired zinc absorption in the elderly are well documented in multiple clinical studies. Adeona is currently conducting a controlled clinical trial to test its proprietary zinc-based therapy for Alzheimer's disease and mild cognitive impairment. All 60 patients should complete their 6 month treatment by the end of March 2011 and it is anticipated that top-line clinical study results should be available shortly thereafter. Adeona's product candidate for age-related macular degeneration has been successfully evaluated in an 80 patient, randomized, placebo-controlled clinical trial. This trial demonstrated statistically significant improvements in multiple parameters of retinal function.

Adeona believes that the product opportunity announced today represents a natural extension of the Company's leading position in developing oral zinc-based therapies for major diseases in the elderly. According to the U.S. Centers for Disease Control, infections attributable to influenza and pneumonia represent the 4th leading cause of death of people age 65 and over in the United States. Influenza and pneumonia alone are estimated to claim the lives of 58,000 seniors a year and infections in seniors are also a major burden on the public health care system.(3)

"We are excited to add a product candidate for the prevention of infection to our
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SOURCE Adeona Pharmaceuticals, Inc.
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