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Addrenex Pharmaceuticals' New Hires Further Company Goal to Identify New Drugs for Adrenergic Regulation
Date:8/19/2008

fluctuations and myriad environmental factors.

To identify new drug candidates, Addrenex will delve into its vast library of 400 adrenergic compounds, housed at the University of Nebraska Medical Center. Addrenex licensed the rights to the portfolio in December, and the company has already produced a new drug candidate-ADX415-from the portfolio. The new compound will be developed for the treatment of hypertension and other potential indications.

Bream will work with University of Nebraska scientists to further analyze various compounds for their affinity to alpha-2 adrenergic receptors and subreceptors that might enhance efficacy or reduce side effects of current alpha-2 compounds. He will be responsible for advancing several drug candidates through the preclinical and early clinical phases.

Butts will work in tandem with the scientific group to identify indications where Addrenex can fill an unmet medical need, Khayrallah said. His expertise in commercializing drugs will help prioritize the most viable drug candidates in the pipeline. Butts will also oversee commercial efforts in the company's current and future partnerships.

"The convergence of commercial and scientific expertise is essential to optimizing our portfolio of drugs," said Khayrallah. "We're now in a position to carefully assess which compounds and which receptors are the best targets for addressing a desired indication."

Gary Bream

Gary Bream brings to Addrenex a decade of regulatory affairs experience and 11 years of clinical research experience. Bream most recently served as senior director of regulatory affairs and strategic drug development services at Constella Group. He also served in the areas of regulatory affairs, clinical operations and clinical research at Constella, formerly Lineberry Research Associates and now SRA International. Bream's career includes scientific positions at Merck Research Laboratories in West Point, PA, and at Burroughs Wellc
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SOURCE Addrenex Pharmaceuticals
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