Navigation Links
Additive Anti-Tumor Activity of NKTR-102 in Combination With Bevacizumab Highlighted in Positive Preclinical Data Presented at AACR Meeting
Date:4/14/2008

profile with reduced gastrointestinal and hematopoietic

toxicity compared to irinotecan with repeat dosing in dogs"

#5742: "NKTR-102, a novel PEGylated-irinotecan, has a superior acute

safety, tolerability, and pharmacokinetic profile compared to irinotecan

in rats and dogs"

Prior data presentations on the anti-tumor activity and pharmacokinetics of NKTR-102 in mouse xenograft models of colorectal, breast and lung cancer can be found at http://www.nektar.com/wt/page/nktr102media.

About NKTR-102

Nektar is developing NKTR-102, a PEGylated form of irinotecan, which was invented by Nektar using its world-leading small molecule PEGylation technology platform. The product is currently in Phase 2 clinical development. Irinotecan is an important chemotherapeutic agent used for the treatment of solid tumors, including colorectal and lung cancers. By applying Nektar's small molecule PEGylation technology to irinotecan, NKTR-102 may prove to be a more powerful and tolerable anti-tumor agent. Preclinical studies show that treatment with NKTR-102 results in significant suppression of tumor growth in an irinotecan-resistant mouse colorectal tumor model and in similar models of breast and lung cancer. Administration of NKTR-102 in an animal model also results in a markedly improved time-concentration profile for SN38, the active metabolite of irinotecan, as compared to treatment with irinotecan.

Nektar PEGylation Platform

Nektar PEGylation technology can enhance the properties of therapeutic agents by increasing drug circulation time in the bloodstream, decreasing immunogenicity and dosing frequency, increasing bioavailability and improving drug solubility and stability. It can also be used to modify pharmaceutical agents to preferentially target certain systems within the body. It is a technique in which non-toxic polyethylene glycol (PEG) polyme
'/>"/>

SOURCE Nektar Therapeutics
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Interim Phase 2 Data for Exelixis XL880 Show Anti-Tumor Activity in Papillary Renal Cell Cancer
2. BiPar Announces Preclinical Data Demonstrating Anti-Tumor Activity With BSI-401, Its Second-Generation PARP Inhibitor
3. Human Genome Sciences Presents New Data Showing Anti-Tumor Activity And Safety Of Trail Receptor Antibodies In Combination With Chemotherapy
4. Updated Phase 1 Data for Exelixis XL184 Demonstrate Pharmacodynamic and Clinical Anti-Tumor Activity
5. Nuvelo Announces Preclinical Data for NU206 Demonstrating Potent Therapeutic Activity in Oral Mucositis Models
6. Update From Mipomersen Extended Dosing Study Continues to Show That Mipomersen Is Well Tolerated and Maintains Activity in Patients Treated for Up to 16 Months
7. Intra-Cellular Therapies Announces the Discovery of Potent Antidepressant Activity in ITI-007
8. Intra-Cellular Therapies Announces the Discovery of Potent Antidepressant Activity in ITI-007/ITI-722
9. Rigels R788 Shows Preclinical Activity in Type 1 Diabetes Model
10. ImQuest Publishes Results of Important Structure Activity Relationship Program on Dual Acting Pyrimidinediones
11. Evotecs EVT 101 Shown to Penetrate the Brain in Man and to Modulate Brain Activity During the Performance of Cognitive Tasks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2015)... VANCOUVER , July 30, 2015  OncoGenex ... it will report its second quarter 2015 financial results ... a conference call and live webcast at 4:30 p.m. ... clinical development programs and a general corporate update. ... the Investor Relations page of the OncoGenex website at ...
(Date:7/30/2015)... N.J., July 30, 2015 PTC Therapeutics, Inc. ... and reported financial results for the second quarter ending ... on many fronts across the organization.  We are excited ... muscular dystrophy clinical trial ever conducted with topline results ... Ph.D., Chief Executive Officer, PTC Therapeutics, Inc. "Translarna is ...
(Date:7/30/2015)... -- Tianyin Pharmaceutical Inc. (NYSE Amex: TPI ) ... patented biopharmaceutical, modernized traditional Chinese medicine (mTCM), branded generics ... notice it received on May 21, 2015 from the ... was below certain of the Exchange,s continued listing standards, ... the NYSE MKT Company Guide, due to the delay ...
Breaking Medicine Technology:PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 2PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 3PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 4PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 5PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 6PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 7PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 8PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 9PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 10TPI Provides Update Regarding Non-Compliance with NYSE MKT Continued Listing Requirements 2
... , WOODCLIFF LAKE, N.J. , May 10 ... today announced that its partner, Glenmark Generics Limited and Glenmark ... agreement with Merck & Co. Inc. that resolves patent litigation ... This settlement effectively ends the lawsuit involving a challenge by ...
... BEIJING , May 10 ... nearly,two-year trial, the ten arbitration cases with Beijing Un-Assegai Technical ... distributor,of clinical diagnostic products in China , as claimant ... as respondent have been decided by the,China International Economic and ...
Cached Medicine Technology:Par's Development and Marketing Partner, Glenmark, Enters Into A Settlement Agreement With Merck To Settle Patent Litigation Over Generic ZETIA(R) 2Assegai Wins Big Settlement Against ABBOTT's Subsidiary 2
(Date:7/31/2015)... ... July 31, 2015 , ... ... What are the STASH awards? The Significant Technological Achievements in Secretive Horticulture ... community as well as tried-and-true products that have stood the test of time. ...
(Date:7/31/2015)... ... ... Bowl 50 will emanate from Levi’s Stadium in Santa Clara, CA on Sunday, February ... In the two weeks that separate the conference championships and the Super Bowl, there is ... will mark the 50th time it has been held and the festivities will take place ...
(Date:7/31/2015)... (PRWEB) , ... July 31, 2015 , ... ... its new store run by GoodThreads. The store can be accessed by visiting ... designs, many of which are customizable. The best part: whenever a product is ...
(Date:7/31/2015)... ... July 31, 2015 , ... Jacksonville-based drug and ... True North Conference Center. The medical community, social workers, law enforcement, and government ... more aligned in the effort to better understand and combat sex trafficking. Lead ...
(Date:7/31/2015)... ... July 31, 2015 , ... Ticket Down is a reliable source of ... catch a new and refreshing show on Broadway, look no further than Hamilton. This ... Obie Award, Outer Critics Circle Award, Drama Desk Award, Lucille Lortel Award, and New ...
Breaking Medicine News(10 mins):Health News:The High Times S.T.A.S.H. Awards Are in, Guess Who Took Home the Prize for “Best Grow System” 2Health News:Cheap 2016 Super Bowl Tickets at Levi's Stadium: Ticket Down Slashes Ticket Prices on Super Bowl 50 Tickets in Santa Clara, CA at Levi's Stadium 2Health News:Mesothelioma Organization Launches New Store 2Health News:Mesothelioma Organization Launches New Store 3Health News:Lakeview Health Links Sex Trafficking and Addiction in Special Jacksonville Educational Workshop 2Health News:Lakeview Health Links Sex Trafficking and Addiction in Special Jacksonville Educational Workshop 3Health News:Cheap Hamilton Tickets at Richard Rodgers Theatre: Ticket Down Slashes Ticket Prices for Hamilton in New York City at the Richard Rodgers Theatre 2Health News:Cheap Hamilton Tickets at Richard Rodgers Theatre: Ticket Down Slashes Ticket Prices for Hamilton in New York City at the Richard Rodgers Theatre 3Health News:Cheap Hamilton Tickets at Richard Rodgers Theatre: Ticket Down Slashes Ticket Prices for Hamilton in New York City at the Richard Rodgers Theatre 4Health News:Cheap Hamilton Tickets at Richard Rodgers Theatre: Ticket Down Slashes Ticket Prices for Hamilton in New York City at the Richard Rodgers Theatre 5Health News:Cheap Hamilton Tickets at Richard Rodgers Theatre: Ticket Down Slashes Ticket Prices for Hamilton in New York City at the Richard Rodgers Theatre 6Health News:Cheap Hamilton Tickets at Richard Rodgers Theatre: Ticket Down Slashes Ticket Prices for Hamilton in New York City at the Richard Rodgers Theatre 7
... ... question the impact the silver screen’s ageless face has on mainstream America. , ... Anaheim, Calif. (PRWEB) December ... actresses. Carla Gugino, an actress of Night at the Museum, Race to Witch ...
... ... based in Texas, announced today that it has expanded its’ continuum of care with the ... ... Recovery, LLC announced today that it has expanded its’ continuum of care to include Origins ...
... ... , ... pages contained within HR 3200, the House Bill that the recently passed Senate Health Care ... to a cooperative effort between Hearthebill.org and iScroll , developers of the evolutionary new ...
... , Department of Health Urges All Pennsylvanians to Get Vaccinated ... Disease Control and Prevention, or CDC, has allocated a total ... date, the state Department of Health said today. , ... health departments, and state health centers. , The ...
... Calif., Dec. 28 With the New Year just around the ... , Lose weight., Exercise more., ... of most New Year,s resolutions is health-related, many tend to forget ... the doctor. Even more so, we forgo the regular visits to ...
... a role for enhanced activation of the signaling protein ... TSC1 or the TSC2 protein. As indicated by Warren ... accompanying commentary, these data provide a rationale for testing ... TSC-associated tumors. Tuberous sclerosis complex (TSC) is a ...
Cached Medicine News:Health News:Dermatologists Dissect Hollywood's Ageless Face Obsession 2Health News:Origins Recovery Centers Announces an Expansion of its Continuum of Care 2Health News:Origins Recovery Centers Announces an Expansion of its Continuum of Care 3Health News:House Health Care Bill Becomes Up To 38% More Understandable 2Health News:Celebrate the New Year With a New You 2
... a handheld manual dispenser, is ideal for ... series pipetting. Its increased volume selection provides ... tasks, and its smooth handling reduces the ... nine Combitips allow a wider range of ...
... of its kind, the noncontact EnSite ... cardiac electrical information, translating it into ... electrodes, this unique tool simplifies ablation ... points of electrical data in a ...
... technologies - Quantum™ LEAP® balloon material ... unite in the Quantum™ Maverick® Balloon ... force balloon with exceptional deliverability. Easier ... shaft technology improves trackability and crossability ...
Inquire...
Medicine Products: