Navigation Links
Additive Anti-Tumor Activity of NKTR-102 in Combination With Bevacizumab Highlighted in Positive Preclinical Data Presented at AACR Meeting
Date:4/14/2008

SAN FRANCISCO, April 14 /PRNewswire-FirstCall/ -- Positive preclinical data was presented by Nektar Therapeutics (Nasdaq: NKTR) this week for its lead oncolytic candidate, NKTR-102 (PEG-irinotecan), which demonstrated enhanced anti-tumor activity in a mouse xenograft model of colorectal cancer when co-administered with bevacizumab. Presented at the American Association for Cancer Research (AACR) Annual Meeting 2008 in San Diego, California, the data also featured the enhanced pharmacokinetic profile and tolerability of NKTR-102, as compared to irinotecan in animal models.

NKTR-102 is a PEGylated form of irinotecan developed using Nektar's innovative small molecule PEGylation technology platform. NKTR-102 is currently in a Phase 2 development program to evaluate its safety and efficacy as a second-line colorectal cancer therapy in combination with cetuximab. Nektar had previously announced its intention to expand the NKTR-102 Phase 2 clinical development program later this year with additional indications.

"NKTR-102 is demonstrating important promise as a solid tumor treatment that could be used in a number of critical cancer care regimens," said Tim Riley, Ph.D., Vice President of PEGylation Research at Nektar. "These data reinforce our confidence in the potential of our small molecule PEGylation technology platform to improve the therapeutic potential of oncolytics that are widely used to treat cancer. We look forward to presenting new data from our clinical trials at additional major oncology conferences this year."

In the preclinical studies presented at AACR, NKTR-102 was co-administered with bevacizumab to evaluate the effects of combination therapy. The combination therapy had an additive effect, inhibiting tumo
'/>"/>

SOURCE Nektar Therapeutics
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Interim Phase 2 Data for Exelixis XL880 Show Anti-Tumor Activity in Papillary Renal Cell Cancer
2. BiPar Announces Preclinical Data Demonstrating Anti-Tumor Activity With BSI-401, Its Second-Generation PARP Inhibitor
3. Human Genome Sciences Presents New Data Showing Anti-Tumor Activity And Safety Of Trail Receptor Antibodies In Combination With Chemotherapy
4. Updated Phase 1 Data for Exelixis XL184 Demonstrate Pharmacodynamic and Clinical Anti-Tumor Activity
5. Nuvelo Announces Preclinical Data for NU206 Demonstrating Potent Therapeutic Activity in Oral Mucositis Models
6. Update From Mipomersen Extended Dosing Study Continues to Show That Mipomersen Is Well Tolerated and Maintains Activity in Patients Treated for Up to 16 Months
7. Intra-Cellular Therapies Announces the Discovery of Potent Antidepressant Activity in ITI-007
8. Intra-Cellular Therapies Announces the Discovery of Potent Antidepressant Activity in ITI-007/ITI-722
9. Rigels R788 Shows Preclinical Activity in Type 1 Diabetes Model
10. ImQuest Publishes Results of Important Structure Activity Relationship Program on Dual Acting Pyrimidinediones
11. Evotecs EVT 101 Shown to Penetrate the Brain in Man and to Modulate Brain Activity During the Performance of Cognitive Tasks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... , 11. Juli 2014  Dilon ... für die molekulare Bildgebung, einschließlich molekularer ... die CE-Zulassung für sein Navigator ® ... Dilon das Produkt jetzt europaweit vertreiben. ... Großteil der europäischen Länder ausgedehnt und ...
(Date:7/10/2014)... , July 10, 2014 Integrated Silicon ... in advanced memory and analog IC solutions, today announced ... Thursday, July 24, 2014, at 7:00 a.m. Pacific Time ... results for the fiscal 2014 third quarter ended June ... via telephone, dial 1-888-556-4997 before 6:50 a.m. Pacific time ...
(Date:7/10/2014)... WEST JORDAN, Utah , July 10, 2014 /PRNewswire/ ... imaging solutions, and MiE America , Inc., a ... systems, have entered into a long-term agreement naming BC ... in the US. MiE and BC ... a strategic agreement to establish BC Technical as the ...
Breaking Medicine Technology:Dilon erhält CE-Zulassung für sein Navigator-Gamma-Sondensystem 2BC Technical Partners With MiE America To Be Authorized Provider Of Systems & Service 2
... , HARRISBURG, Pa., Aug. 20 Department of Environmental ... number of West Nile Virus cases has dropped, the threat still ... and make every effort to control mosquitoes and reduce the threat ... number of West Nile cases has substantially decreased in recent years ...
... , , , , ... Stemedica Cell Technologies , Inc. USA, a ... New Drug (IND) meeting with the U.S. Food and Drug Administration ("FDA") ... mesenchymal bone marrow cells (adult human) as a treatment for ischemic stroke. ...
Cached Medicine Technology:DEP Urges Pennsylvanians to Take Precautions to Reduce West Nile Virus Threat 2DEP Urges Pennsylvanians to Take Precautions to Reduce West Nile Virus Threat 3Stemedica Requests Pre-IND Meeting With FDA 2
(Date:7/12/2014)... The report, "Phthalic Anhydride and Derivatives (Plasticizers, Unsaturated Polyester ... – Trends & Forecast to 2018," defines and segments ... volume and value. The report also estimates the demand ... phthalic anhydride is projected to grow from an estimated ... with a CAGR of 5.24% from 2013 to 2018. ...
(Date:7/12/2014)... (PRWEB) July 12, 2014 ... research report, ‘cognitive assessment and training’ is ... monitor, assess, train, or enhance cognitive functions. ... such as in dementia screening, clinical trials, ... classroom learning, self assessment, brain training, and ...
(Date:7/12/2014)... (PRWEB) July 12, 2014 The fastest-growing ... for test and measurement of LTE networks continues to ... demands for smart devices have increased mobile data traffic, ... and Measurement (CT&M) market. Communications Test and Measurement equipment ... requirements. , The Communications Test and Measurement Market is ...
(Date:7/12/2014)... 2014 (HealthDay News) -- If you make exercise fun, you,ll ... one experiment, 56 adults were led on a 1.4-mile walk ... or a scenic walk. The participants were given lunch after ... exercise outing ate 35 percent more chocolate pudding for dessert ... In another experiment, 46 adults were given mid-afternoon snacks ...
(Date:7/12/2014)... (PRWEB) July 12, 2014 Sean Francis, owner of ... out special challenges to his clients. He’s also known for his ... recently found a way to combine the two and is excited ... $2,000 for the Boys and Girls Club. , The funds are ... started on June 23rd. Francis sent out emails and asked his ...
Breaking Medicine News(10 mins):Health News:Phthalic Anhydride Market Projected to Reach $8.42 Billion by 2018 – Report by MarketsandMarkets 2Health News:Phthalic Anhydride Market Projected to Reach $8.42 Billion by 2018 – Report by MarketsandMarkets 3Health News:Phthalic Anhydride Market Projected to Reach $8.42 Billion by 2018 – Report by MarketsandMarkets 4Health News:Global Cognitive Assessment & Training Market: 27.3% CAGR to 2018 Says a New Research Report Available at LifeScienceIndustryResearch.com 2Health News:Global Cognitive Assessment & Training Market: 27.3% CAGR to 2018 Says a New Research Report Available at LifeScienceIndustryResearch.com 3Health News:Global Cognitive Assessment & Training Market: 27.3% CAGR to 2018 Says a New Research Report Available at LifeScienceIndustryResearch.com 4Health News:Global Cognitive Assessment & Training Market: 27.3% CAGR to 2018 Says a New Research Report Available at LifeScienceIndustryResearch.com 5Health News:North America Communication Test and Measurement (CT&M) Market Worth $1.9 Billion by 2018 - New Report by MicroMarket Monitor 2Health News:North America Communication Test and Measurement (CT&M) Market Worth $1.9 Billion by 2018 - New Report by MicroMarket Monitor 3Health News:North America Communication Test and Measurement (CT&M) Market Worth $1.9 Billion by 2018 - New Report by MicroMarket Monitor 4Health News:North America Communication Test and Measurement (CT&M) Market Worth $1.9 Billion by 2018 - New Report by MicroMarket Monitor 5Health News:Make Exercise Fun, Eat Less Afterwards 2Health News:Kawartha Lakes Fit Body Boot Camp’s Successful Fat Loss Challenge Results in $2,000 to Boys and Girls Club 2Health News:Kawartha Lakes Fit Body Boot Camp’s Successful Fat Loss Challenge Results in $2,000 to Boys and Girls Club 3
... Prize Announced to Recognize Outstanding Journalism in, Support of Parkinson,s Disease ... ... NEW YORK, May 9 Although the weatherman predicted rain,that did not ... on Saturday, April 26th to unite as a passionate and,dedicated community to ...
... Sunrise Senior Living,Inc. (NYSE: SRZ ), today announced ... at the 2008 Bank of America Healthcare,Conference in Las ... Pacific,Time., Sunrise will Web cast the presentation live ... http://www.sunriseseniorliving.com ). A,replay of the Web cast will be ...
... May 9 Claremont Insurance,Services ( http://www.claremontcompanies.com ... today announced an innovative partnership to,market and ... broker,channel. PayrollSelect expands the selling power and ... an additional recurring revenue,stream for the broker ...
... to have suffered from depression before the diagnosis, , , ... are more than twice as likely to develop post-traumatic ... anxiety disorders, new research suggests. , About 16 percent ... at the Ohio State University Medical experienced PTSD 18 ...
... Washington University School of Medicine in St. Louis working ... immune cells long thought to be responsible for type ... the immune cells from isolated insulin-making structures in the ... the immune cells, known as dendritic cells, "red-handed": carrying ...
... Force,Colonel Mike Turner, a Democratic candidate for U.S. Congress ... inspired by MSNBC host,Keith Olbermann. Today is the 169th ... key architect of Hillary Clinton,s,notorious 1993 health care plan, ... 10th District voters what, if any, plan she has ...
Cached Medicine News:Health News:14th Annual Parkinson's Unity Walk Most Successful Event to Date 2Health News:14th Annual Parkinson's Unity Walk Most Successful Event to Date 3Health News:New Payroll Service Expands Selling Power and Service Capability of Employee Benefits Brokers 2Health News:Mood Disorders Put Breast Cancer Patients at Risk for PTSD 2Health News:Suspected cause of type 1 diabetes caught 'red-handed' for the first time 2Health News:Suspected cause of type 1 diabetes caught 'red-handed' for the first time 3Health News:Mike Turner, Virginia Congressional Candidate, Starts Healthcare Countdown 2
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: