Navigation Links
Additional Data From Multiple Phase 1 and 2 Studies of S*BIO's Novel JAK2 Inhibitor SB1518 Demonstrate Safety and Efficacy for Treatment of Symptomatic Myelofibrosis (MF)
Date:6/1/2011

hose with thrombocytopenia.16th Congress of EHAPoster No. 907 (5:30-6:45 p.m. BST, Saturday, June 11)Long-Term Safety and Efficacy Analysis of the Two Phase 1 Studies of SB1518, a Novel Oral JAK2 Inhibitor, in Patents With Advanced Myeloid Malignancies

SB1518 shows promising efficacy in MF patients with splenomegaly. Once-daily dosing is well tolerated to 29 months, with manageable GI toxicity as the main AE. SB1518 does not appear to cause myelosuppression; patients with significantly impaired hematopoiesis can receive full-dose daily SB1518 without exacerbating hematocytopenias. Sixty-three patients were consented and enrolled; 39 (62%) were men, and median age was 65.5 years. Fifty-six had MF, and 7 had AML. Median time on study is 13.3 months (1-29+). As of January 2011, 21 MF patients remain on study. The most common treatment-related AEs were gastrointestinal, which were generally low grade and manageable. These events occurred after 5.7-18.5 months on study. Two patients were discontinued for these AE's and one continues on study at 200 mg dose. Fifteen patients had dose reductions, most within the first 6 months; of these, 11 (73%) started treatment at >500 mg/d. No patients discontinued study medication because of a dose-limiting toxicity. No long-term toxicities were identified. Forty-one MF patients had palpable baseline splenomegaly >5 cm and were evaluable for spleen response. Overall, 39 (70%) of the 56 MF patients experienced CI or stable disease. Among all enrolled patients, duration of progression-free survival (PFS) ranged from 1 to 875 days (median, 563 days), with an estimated 67% rate of PFS at 12 months (Kaplan-Meier).Presentation No. 1022 (8:30-8:45 a.m. BST, Sunday, June 12)Phase 2 Study of SB1518, a Novel Oral JAK2 Inhibitor, in Patients with Primary, Post-Polycythemia Vera, and Post-Essential Thrombocythemia Myelofibrosis

SB1518 showed promising
'/>"/>

SOURCE S*BIO Pte Ltd
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Additional Data From QNEXA Clinical Trials Presented at the European Congress on Obesity
2. Hope Paige Designs Medical ID Bracelets Now Available in 1,100 Additional Locations
3. Ardea Biosciences Provides Additional Results From a Phase 2b Study of Lesinurad in Combination With Allopurinol at the Annual European Congress of Rheumatology
4. Omeros Reports Allowance of Additional Patent for Arthroscopic Product
5. Cynosure Receives Additional International Regulatory Approvals for New Cellulite Reduction Workstations
6. Data Presented at Digestive Disease Week Highlights Additional Analysis of DIFICID™ Phase 3 Data
7. Rosetta Genomics Announces Issuance of Additional U.S. Patent
8. HeartWare Reports Additional Data from Bridge-to-Transplant Clinical Trial and Continued Access Patients
9. Johnson & Johnson Provides Additional Information Regarding Amended Agreement With Merck
10. Southern Home Medical Equipment Reports Additional Revenues and Profits for 2010
11. Additional 8 Products of DK Sinopharma, Inc. are Included in 2010 Provincial Medical Insurance Catalogs in 4 Separate Provinces in the Peoples Republic of China
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... 10, 2014  Valeant Pharmaceuticals International, Inc. (NYSE: ... has completed the sale to Galderma of all rights ... held by Valeant for $1.4 billion in cash, pursuant ... recently completed its acquisition of Galderma. ... products to a company that is firmly committed to ...
(Date:7/10/2014)... -- Decision Resources Group finds that over half of ... Drug Administration,s (FDA) approval of Vifor Fresenius Medical Care ... by the FDA in November 2013 for the treatment ... dialysis. Other key findings from the report ... : , Bundling: Based ...
(Date:1/15/2014)... As health officials across the Midwest warn against the ... Michigan will offer free diagnostic testing ... pharmacists to administer tests and, in some cases, fill the ... in the study. The Grand Rapids, ...
Breaking Medicine Technology:Half of Surveyed Nephrologists Report Moderate Familiarity with Velphoro, Which Received FDA Approval Late Last Year for the Treatment of Hyperphosphatemia in Dialysis 2Half of Surveyed Nephrologists Report Moderate Familiarity with Velphoro, Which Received FDA Approval Late Last Year for the Treatment of Hyperphosphatemia in Dialysis 3Meijer Pharmacy Offers Free Flu, Strep Testing as Influenza Cases Rise Across the Midwest 2Meijer Pharmacy Offers Free Flu, Strep Testing as Influenza Cases Rise Across the Midwest 3
... Speaking today at the plenary session of ... Klaus Schwamborn, CDO of Pepscan Therapeutics, presented Pepscan,s protein ... In his presentation ,CLIPS meets GPCRs, Dr. Schwamborn ... of immunogen design. He showed data demonstrating that Pepscan,s ...
... announced that Leroy Hood, MD, PhD, a world recognized leader ... Scientific Advisory Board.  "High multiplex qPCR diagnostics ... clinic," commented Dr. Hood.  "I am delighted to help PrimeraDx ... to a robust molecular diagnostics solution." "Lee brings ...
Cached Medicine Technology:Pepscan Therapeutics Presents Protein Mimicry Platform for the Discovery of anti-GPCR Antibodies at International Antibody Conference 2PrimeraDx Appoints Leroy Hood to its Scientific Advisory Board 2
(Date:7/13/2014)... 2014 A decreased ability to identify odors ... Alzheimer,s disease, while examinations of the eye could ... with Alzheimer,s, in the brain, according to the ... the Alzheimer,s Association International Conference 2014 (AAIC 2014) ... the decreased ability to identify odors was significantly ...
(Date:7/13/2014)... 2014 Celebrity fitness trainer and former ... promotional partnership with Aqua Health Labs for their flagship ... supplement . The collaboration was recently announced live on ... trainer , actor, model, and a two time World ... celebrities, he has prepared stars including Demi Moore, Hilary ...
(Date:7/13/2014)... According to The Peripheral Neuropathy Program review ... that teaches people how to deal with diabetic nerve ... This program also provides people with safe and effective ... including numbness, prickling, burning, and intense stabbing pains. ... treatment program can help people eliminate some types of ...
(Date:7/12/2014)... Recently, Fadhits.com, a well-known wedding dress manufacturer and retailer, has ... to its product line. In addition, the company has ... to bring more benefits for its loyal fans. All ... up to 72% off. , As a leader in the ... shop is a good place for ladies who want to ...
(Date:7/12/2014)... 12, 2014 Fresh off their respective performances ... will meet on September 5th at Sun Life Stadium in ... see some of the brightest stars in the world of ... Miami will be treated to some of the best talent ... ranked as the third best team in the world according ...
Breaking Medicine News(10 mins):Health News:Smell and eye tests show potential to detect Alzheimer's early 2Health News:Smell and eye tests show potential to detect Alzheimer's early 3Health News:Smell and eye tests show potential to detect Alzheimer's early 4Health News:Smell and eye tests show potential to detect Alzheimer's early 5Health News:Smell and eye tests show potential to detect Alzheimer's early 6Health News:Smell and eye tests show potential to detect Alzheimer's early 7Health News:Celebrity Fitness Expert Supports Revolutionary New Health Supplement 2Health News:The Peripheral Neuropathy Program Review Exposes Randall Labrum's Peripheral Neuropathy Treatment Program – Vkool.com 2Health News:The Peripheral Neuropathy Program Review Exposes Randall Labrum's Peripheral Neuropathy Treatment Program – Vkool.com 3Health News:New Collection of Long Graduation Dresses Revealed by Fadhits.com 2Health News:Brazil Vs. Colombia Tickets Sun Life Stadium: Ticket Down Slashes Ticket Prices for Friendly Match Between Colombia and Brazil 2Health News:Brazil Vs. Colombia Tickets Sun Life Stadium: Ticket Down Slashes Ticket Prices for Friendly Match Between Colombia and Brazil 3
... has improved substantially over the last 35 years in ... improvements in clinical management, according to a study in ... potentially dangerous condition that may develop in late pregnancy ... excessive weight gain, and the presence of protein in ...
... the use of tainted human body parts, lifted off human ... as implants for patients. This information came to light, notwithstanding ... interest take precedence over issues of secrecy, in keeping with ... is thought to be the work of a corpse-robbing gang ...
... who live in far-flung areas run a grave risk of ... an increase in the rates of// heart disease, diabetes and ... Canadian Institute for Health Information. , ,According ... had increased by 14 per cent in the god-forsaken areas ...
... partly attributed to the increased prevalence of the procedure among ... Paltrow have all opted for the C-section and this is ... their example. ,'There's no doubt in my mind ... ignited by the fact that in our pop culture many ...
... treatment mainstay for prostate cancer puts men at increased ... large observational study published in the// Sept. 20 Journal ... have high five-year survival rates, but they also have ... study author Nancy Keating, MD, MPH, assistant professor of ...
... Gawande has won a "no strings attached" $500,000 "genius" ... MacArthur Foundation//. ,Gawande, 40, whose many articles and ... him one of the most recognised of American writers, ... 2006 announced by the Foundation in Chicago Tuesday. ...
Cached Medicine News:Health News:Improvement Seen in Fetal Survival Following Preeclampsia 2Health News:Stolen Body Parts From Human Cadavers used as Implants by 25 UK Hospitals 2Health News:Rural Canadians, Take Care Of Your Health 2Health News:Prostate Cancer Treatment Increases Risk of Diabetes and Heart Disease 2Health News:Indian American Surgeon Wins US "Genius" Award 2
2 tests on one meter. Glucose test for immediate glucose levels. GlucoProtein (Fructosamine) for overall control, average over prior 2-3 weeks. The Duet is the only hand held instrument to perform th...
The DOT-approved A150 test is used for workplace testing, most publicly for federally mandated testing of transportation workers, but also in private company "drug free workplace" programs. Each hash...
... QuickScreen multi-panel dip cards offer minimal exposure ... of any conceivable combination of 9 different ... your drug testing program. Just dip the ... timer tells you when to read the ...
... SureStep™ Drug Screen Tests are available in ... MDMA (Ecstasy). Designed using Microgenics Antibody Technology, ... only point of care immunoassay targeted to ... both MDA and MDEA but no cross-reactivity ...
Medicine Products: