Navigation Links
Additional Data From Multiple Phase 1 and 2 Studies of S*BIO's Novel JAK2 Inhibitor SB1518 Demonstrate Safety and Efficacy for Treatment of Symptomatic Myelofibrosis (MF)
Date:6/1/2011

er-stage clinical studies."

SB1518 is a small molecule JAK2-selective kinase inhibitor, which has demonstrated high potency in preclinical models against both the wild type JAK2 kinase and the JAK2 kinase with the V617F mutation. The V617F mutation is found in high frequencies in myeloproliferative disorders such as MF. It is estimated that approximately 50% of patients with MF possess the JAK2 mutation.

2011 ASCO Annual MeetingPoster Board 7, Abstract No. 6515 (2-6 p.m. CDT, Friday, June 3)Poster Discussion Session (5-6 p.m. CDT, Friday, June 3)Phase 2 Study of SB1518, an Orally Available Novel JAK2 Inhibitor, in Patients with Myelofibrosis

SB1518 showed promising efficacy in symptomatic MF patients with splenomegaly. Once daily dosing was well tolerated, with manageable grade 1 and 2 GI toxicity as the main side effect. Patients with significantly impaired hematopoiesis could receive full-dose daily of SB1518 without exacerbating hematocytopenias. Thirty-three patients with MF were enrolled. Median spleen enlargement by physical examination (PE) was 18 cm below the LCM. Of 30 patients assessed by MRI, 29 had a spleen volume reduction; 17 (57%) had a reduction of > 25%. Of 31 patients assessed by PE, 12 (39%) had a reduction of >50%, and seven (23%) had a reduction of 100%. Results showed that a 50% reduction in spleen length by PE corresponded to a 25% reduction in spleen volume by MRI (p=0.043). Intensity of MF-related symptoms decreased by 40-65% in patients treated for 6 months. The most common treatment-related toxicities were diarrhea (81%; 6% Gr 3), nausea (41%; all Gr 1/2), vomiting (22%; all Gr 1/2), and fatigue (9%; all Gr 1/2). These events were readily managed. At six months, 21 patients remain on therapy. Significant neutropenia and thrombocytopenia were not seen (no Gr 3/4 events). SB1518 was tolerated equally well by patients with normal platelet counts and t
'/>"/>

SOURCE S*BIO Pte Ltd
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Additional Data From QNEXA Clinical Trials Presented at the European Congress on Obesity
2. Hope Paige Designs Medical ID Bracelets Now Available in 1,100 Additional Locations
3. Ardea Biosciences Provides Additional Results From a Phase 2b Study of Lesinurad in Combination With Allopurinol at the Annual European Congress of Rheumatology
4. Omeros Reports Allowance of Additional Patent for Arthroscopic Product
5. Cynosure Receives Additional International Regulatory Approvals for New Cellulite Reduction Workstations
6. Data Presented at Digestive Disease Week Highlights Additional Analysis of DIFICID™ Phase 3 Data
7. Rosetta Genomics Announces Issuance of Additional U.S. Patent
8. HeartWare Reports Additional Data from Bridge-to-Transplant Clinical Trial and Continued Access Patients
9. Johnson & Johnson Provides Additional Information Regarding Amended Agreement With Merck
10. Southern Home Medical Equipment Reports Additional Revenues and Profits for 2010
11. Additional 8 Products of DK Sinopharma, Inc. are Included in 2010 Provincial Medical Insurance Catalogs in 4 Separate Provinces in the Peoples Republic of China
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/22/2014)... MOUNTAIN VIEW, Calif. , Oct. 22, ... 11:00 a.m. EDTLOCATION: Online, complimentary registration available ... Group Team Leader Archana Vidyasekar and Visionary ... VargheseBrain-controlled computers, WiFi-like wireless electricity, self-assembling materials, ... top ten technologies which will transform our ...
(Date:10/22/2014)... 2014  AcelRx Pharmaceuticals, Inc. (NASDAQ: ... IAP310 study have been published in Regional ... journal with broad, multidisciplinary readership. IAP310 was a ... and efficacy of Zalviso, also referred to as ... treatment of post-operative pain in patients following open ...
(Date:10/22/2014)... CAMBRIDGE, Mass. and SHANGHAI ... Inc. (NASDAQ: FMI ) and WuXi ... announced a collaboration to offer Foundation Medicine,s comprehensive genomic ... China . Under the ... enable WuXi to perform the laboratory component of Foundation ...
Breaking Medicine Technology:Futuristic Technologies That Will Transform Our World Beyond 2030 2Futuristic Technologies That Will Transform Our World Beyond 2030 3Futuristic Technologies That Will Transform Our World Beyond 2030 4AcelRx Announces Publication of Zalviso Phase 3 Abdominal Trial Results 2Foundation Medicine and WuXi PharmaTech Announce Strategic Collaboration to Offer Best-in-Class Comprehensive Genomic Profiling in China 2Foundation Medicine and WuXi PharmaTech Announce Strategic Collaboration to Offer Best-in-Class Comprehensive Genomic Profiling in China 3Foundation Medicine and WuXi PharmaTech Announce Strategic Collaboration to Offer Best-in-Class Comprehensive Genomic Profiling in China 4Foundation Medicine and WuXi PharmaTech Announce Strategic Collaboration to Offer Best-in-Class Comprehensive Genomic Profiling in China 5
... Inc. (Inspiration) announced today that the European Commission has ... of hemophilia.  Expected to enter pivotal clinical trials before ... treat individuals with hemophilia who have developed inhibitors against ... trigger a 10-year market exclusivity for OBI-1 in the ...
... DIEGO, Oct. 19 Aethlon Medical, Inc. (OTC Bulletin ... therapeutic filtration devices to address infectious disease and cancer, ... the Aethlon Medical board of directors. ... ) Mr. Kenley has 33 years of ...
Cached Medicine Technology:Inspiration Biopharmaceuticals' OBI-1 Receives Orphan Drug Designation in Europe 2Inspiration Biopharmaceuticals' OBI-1 Receives Orphan Drug Designation in Europe 3Aethlon Medical Announces Appointment of Rod Kenley to Its Board of Directors 2Aethlon Medical Announces Appointment of Rod Kenley to Its Board of Directors 3Aethlon Medical Announces Appointment of Rod Kenley to Its Board of Directors 4Aethlon Medical Announces Appointment of Rod Kenley to Its Board of Directors 5
(Date:10/22/2014)... Best Cheap Hosting USA is among the ... has recently announced that iPower ( http://www.best-cheap-hosting-usa.com/go/iPower/ ) is ... around the world. , “iPower is one of the ... providing various kinds of useful products for new and ... excellent customer service and a number of features which ...
(Date:10/22/2014)... Richard Carlson, Managing Partner of Blue ... over 25 years experience. Mr. Carlson is a ... related to EDI, B2B Commerce, RFID and Internet/Intranet technology. ... Board member for Pharmaceutical Commerce Magazine and a Gerson ... is a management and technology consulting firm focused solely ...
(Date:10/22/2014)... Tara Haelle HealthDay Reporter , ... young adult men may lead to increased blood pressure, according ... a similar rise in blood pressure for young adult women ... young adult women drank lightly or moderately, their risk of ... "This finding parallels studies in older adult men and ...
(Date:10/20/2014)... 20, 2014 The newly updated Worldwide ... of thousands of facts, figures and forecasts on the ... medical sector forecast categories the Worldwide Medical Market ... and national views on the worldwide medical market to ... report gives you data for 2010-2019, covering each country ...
(Date:10/20/2014)... Women’s health specialist, Dr. Amber Murphy, ... of Columbus, Inc., A Division of MaternOhio Clinical Associates, ... than 100,000 patients annually. Dr. Murphy will provide a ... of a women’s life. She is accepting new patients ... and Dublin. , Dr. Murphy offers a wide variety ...
Breaking Medicine News(10 mins):Health News:Best Cheap Hosting USA Has Recently Announced The Best Cheap Web Hosting Companies In 2014 2Health News:Rich Carlson and Marc Duey to Hold Workshop at CBI’s Specialty Pharmacy and Distribution Networks Conference 2Health News:Binge Drinking May Boost Blood Pressure in Young Men 2Health News:Binge Drinking May Boost Blood Pressure in Young Men 3Health News:Binge Drinking May Boost Blood Pressure in Young Men 4Health News:Worldwide Medical Market Forecasts to 2019 a New Research Report Added to ReportsnReports.com 2Health News:Worldwide Medical Market Forecasts to 2019 a New Research Report Added to ReportsnReports.com 3Health News:Worldwide Medical Market Forecasts to 2019 a New Research Report Added to ReportsnReports.com 4Health News:OhioHealth Welcomes New Women’s Health Specialist to MaternOhio Specialists in Obstetrics & Gynecology of Columbus, Inc. 2Health News:OhioHealth Welcomes New Women’s Health Specialist to MaternOhio Specialists in Obstetrics & Gynecology of Columbus, Inc. 3
... ... Announced That It Has Been Selected As A 2010 Emerging Technology Vendor By CRN Magazine. ... Philadelphia, PA (PRWEB) July ... announced that it has been selected as a 2010 Emerging Technology Vendor by CRN Magazine. ...
... , ... Association HealthCare Professionals (IAHCP) welcomes esteemed psychiatrist Dr. Lyubov Gorelik into the pages thier ... representing New York State as a leader in psychiatry, and will be featured alongside ... ...
... ... Oxford House , ... 3, 2010 -- “Oxford House is a true blessing for those who really want recovery.” This ... Today, author Joe Chavez shares their stories in I Second The Motion: Learning to Live Sober, ...
... Featuring over 200 ... need of a mobility solution for their home. Customers will benefit from exclusive catalog pricing ... ... retailer of more than 10,000 medical and mobility products, announced the publication of its 2010 ...
... Anthony Booth, a ... the aisle thanks to Leeds Teaching Hospitals Trust and Leeds based prosthetics specialists RSLSteeper. A ... new limbs. , ... 6, 2010 -- Leeds Teaching Hospitals Trust and RSLSteeper team up to help Paralympian walk ...
... (WASHINGTON, July 1, 2010) Older patients with Hodgkin ... high risk of hospitalization for cardiac complications after completing treatment, ... the journal of the American Society of Hematology. HL is ... and approximately 8,500 people were diagnosed with the disease in ...
Cached Medicine News:Health News:Neuxpower Selected as 2010 Emerging Technology Vendor by CRN Magazine 2Health News:Renowned Psychiatrist, Lyubov Y Gorelik, M.D., is selected to represent New York in The Leading Physicians of the World 2Health News:Oxford House: Where Stories of Recovery Are Born 2Health News:US Medical Supplies Publishes 2010 Catalog 2Health News:Leeds Teaching Hospitals Trust and RSLSteeper Team Up to Help Paralympian Walk His Sister Down the Aisle 2Health News:Leeds Teaching Hospitals Trust and RSLSteeper Team Up to Help Paralympian Walk His Sister Down the Aisle 3Health News:Lymphoma patients with cardiovascular disease have increased risk of cardiac hospitalization 2
... The FR-120F, Fujinon's new fiberoptic Naso-Pharyngo-Laryngoscope ... and patient comfort. The latest in ... an increased light guide, and a wide ... very impressive 3.3mm distal tip diameter. ...
... Medical's Articulating Tip Laryngoscopes are ... the Industry. The articulating tip ... providing an improved view of ... Fiber Optic styles. We guarantee ...
CCR Medical fiberoptic green system laryngoscope handles., ,OUTSTANDING PERFORMANCE, QUALITY, AND PRICING MAKE OUR FIBEROPTIC SELECTION MOST ECONOMICAL....
CCR Medical conventional laryngoscopes....
Medicine Products: