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Addition of INTEGRILIN(R) (Eptifibatide) to Bivalirudin Plus Standard of Care Inhibits Platelet Aggregation in Patients Undergoing Elective Coronary Stenting
Date:11/5/2007

to demonstrate the inhibitory effect of INTEGRILIN(R) on the physical characteristics of a platelet-fibrin clot.

CLEAR PLATELETS 2 builds on the results of the original CLEAR PLATELETS study, which demonstrated that adding INTEGRILIN(R) to a 300-mg loading dose of clopidogrel produced greater platelet inhibition and reduced cardiac biomarkers than clopidogrel alone in patients undergoing elective stenting. Data from this study were presented at the 2004 American Heart Association Scientific Sessions. CLEAR PLATELETS 2 was an investigator-initiated study funded by Schering-Plough.

About Sinai Hospital of Baltimore

Sinai Hospital of Baltimore is a member of LifeBridge Health, a regional health organization, which includes Northwest Hospital Center, Levindale Hebrew Geriatric Center and Hospital, Jewish Convalescent & Nursing Home and related subsidiaries and affiliates.

About INTEGRILIN(R) Injection

INTEGRILIN(R) is indicated for the treatment of patients with acute coronary syndrome (unstable angina/non-ST-segment-elevation myocardial infarction), including patients who are to be managed medically and those undergoing percutaneous coronary intervention (PCI). It is also indicated in the United States for the treatment of patients at time of PCI, including in patients undergoing intracoronary stenting.

INTEGRILIN(R) is contraindicated in patients with a history of bleeding diathesis, or evidence of abnormal bleeding within the previous 30 days; severe hypertension (systolic blood pressure greater than 200 mm Hg or diastolic blood pressure greater than 110 mm Hg) not adequately controlled on antihypertensive therapy; major surgery within the preceding six weeks; history of stroke within 30 days, or any history of hemorrhagic stroke; current or planned administration of another parenteral GP IIb-IIIa inhibitor; dependency on renal dialysis; or known hypersensitivity to any component of the product.

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SOURCE Schering-Plough Corporation
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