Navigation Links
Addition of INTEGRILIN(R) (Eptifibatide) to Bivalirudin Plus Standard of Care Inhibits Platelet Aggregation in Patients Undergoing Elective Coronary Stenting
Date:11/5/2007

h stenting who were given high-dose clopidogrel (600 mg) in the absence of chronic clopidogrel therapy and aspirin (325 mg) and then randomized to either a bivalirudin alone (n=102) or bivalirudin + INTEGRILIN(R) (n=98). The primary outcome of the study was to compare the antiplatelet effects of bivalirudin vs. bivalirudin plus INTEGRILIN(R) in patients being treated with clopidogrel and aspirin at the time of elective percutaneous intervention. Secondary outcomes were the release of markers of myocardial necrosis, inflammatory markers and in- hospital, 30-day, and 1-year clinical outcomes.

All patients post-stenting received standard antiplatelet treatment (75 mg clopidogrel and 325 mg aspirin daily). Patients had serial assessment of platelet reactivity, myocardial necrosis markers, and inflammatory markers at baseline, 2 hours, 8 hours, and 18-24 hours post-stenting. Blood work was processed at The Sinai Center for Thrombosis Research and the University of Oklahoma Health Science Center. Platelet reactivity was measured by aggregometry and flow cytometry. Thrombelastography measured the characteristics of maximum platelet-fibrin clot strength and time to initial platelet-clot formation. Clinical outcomes were recorded using a standard case report form. Patients were followed to 30 days, and will be further followed to one year. In the secondary outcome of 30-day clinical events, the rate of periprocedural myocardial infarction in the bivalirudin plus INTEGRILIN(R) treatment arm was 2% vs. 9% in the bivalirudin alone treatment arm. Statistical significance of these findings has not yet been confirmed.

Bivalirudin plus INTEGRILIN(R) compared to bivalirudin alone produced greater relative inhibition of platelet aggregation induced by 5 or 20 uM ADP, 15 or 25 uM TRAP, or collagen (p<0.01 for all). Platelet reactivity and maximum platelet-fibrin clot strength were higher in patients with myocardial infarction.

This is the first study in PCI patients
'/>"/>

SOURCE Schering-Plough Corporation
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Callisto Pharmaceuticals Opens Additional Sites for Phase II Clinical Trial of Atiprimod in Advanced Carcinoid Cancer Patients
2. Par Pharmaceutical Begins Shipment of Additional Dosage Strength of Generic TOPROL-XL(R)
3. First Osteoporosis Study in Hip Fracture Patients Finds Once-Yearly Reclast(R) Prevents Additional Fractures and Improves Survival
4. PTC Therapeutics Announces Additional Results from Phase 2 Study of PTC124 in Duchenne Muscular Dystrophy
5. Bayer Issues Additional Guidance to Physicians on Trasylol(R)
6. Coley Pharmaceutical Group and Pfizer Nominate Additional Anti-Cancer Compound for Clinical Development
7. Progen Presents Additional Analysis of Data from PI-88 Phase 2 Liver Cancer Study at American Association for the Study of Liver Diseases
8. Wyeths Torisel and Roche/Genentechs Avastin Will Challenge Pfizers Sutent to Become the Clinical Gold Standard for Treatment of Metastatic Renal Cell Carcinoma
9. Virogenomics, Inc. Awarded $2 Million National Institute of Standards and Technology (NIST) Advanced Technology Program Grant to Develop Integrated Diagnostic Biosensors
10. Semafores PI3 Kinase Inhibitor SF1126 is Active Against Tumor and Tumor Cells and Synergizes with Standard Chemotherapy Agents
11. Cleveland Clinic Researchers Identify Mechanism Behind Platelet Function and Potentially Fatal Blood Clot Formation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/24/2014)... -- Lockton Dunning Benefits, the Dallas ... of Vice President Kim Foerster on ... team, Excelsior Solutions. Foerster brings ... position.  Most recently, she worked as the Director ... where she has held various managerial positions since ...
(Date:12/24/2014)... HILL, N.C. , Dec. 23, 2014  Medical ... success. As the key link between the medical device ... grow even more in the coming years as the ... According to research by benchmarking firm, ... MSLs can gain an important edge is by harnessing ...
(Date:12/22/2014)... , Dec. 22, 2014   TRU-D SmartUVC ... UV disinfection robot, announced today that the General Services ... through November 2019.   This newly formed ... all levels of government purchasers, including Department of Veteran ... as Homeland Security contacts purchasing solutions for the Ebola ...
Breaking Medicine Technology:Kim Foerster Joins Lockton Companies 2Role of Medical Science Liaisons Evolving in Medical Device Sector 2TRU-D SmartUVC LLC Awarded General Services Administration Contract to Expand Government Customer Base 2
... 2011 /PRNewswire-iReach/ --  Janet R. Dees, CEO/President of ... opening of its newest vascular access center in Columbus, ... success for American Vascular Access, LLC., and the addition ... R. Dees, CEO/President.   "Our goal has continued ...
... Holdings, Inc. (NYSE: ZMH ; SIX: ZMH), a ... of its CLS® Brevius ™ Hip Stem with ... new technology enables surgeons to better match patients, individual ... adjustments. "Following its introduction in Europe earlier ...
Cached Medicine Technology:American Vascular Access Continues Growth in Georgia 2Zimmer Introduces New CLS® Brevius™ Hip Stem with Kinectiv® Technology in the United States 2Zimmer Introduces New CLS® Brevius™ Hip Stem with Kinectiv® Technology in the United States 3
(Date:12/25/2014)... 2014 The short film “Color of Honor” ... honor of a true 9/11 hero, Welles Remy Crowther. It ... the 24 hours of Nuremberg International Short Film Festival and ... Actress, screenwriter and director Luciana Lagana plays the ... with her husband, Gregory Graham - Graham plays ...
(Date:12/25/2014)... When head lice hits a home or school, ... get rid of it while keeping it from taking over ... have the solution right in their neighborhood: Lice Troopers ... provides full spectrum head lice screening and treatment services to ... Key Biscayne, Brickell, Coconut Grove, Kendall, Pinecrest and South Miami. ...
(Date:12/25/2014)... (HealthDay News) -- Overeating is common during the holidays, but ... an expert says. "Don,t arrive at a party hungry. ... know you,ll be attending a party, but deprivation leads to ... at Northern Westchester Hospital in Mount Kisco, N.Y., said in ... during the day and even to have a snack before ...
(Date:12/25/2014)... 2014 Thousands of transvaginal mesh lawsuits ... a number of multidistrict litigations currently underway in U.S. ... LLP reports. According to an Order issued on December ... Joint Status Conference in all of the proceedings on ... directed to submit a proposed agenda to the Court ...
(Date:12/25/2014)... Rosa, CA (PRWEB) December 25, 2014 ... department visits and 2 million hospital admissions across the ... and Prevention ). The CDC’s National Hospital Ambulatory ... departments through a survey conducted in 2010. They estimated ... department visits that resulted in a primary diagnosis of ...
Breaking Medicine News(10 mins):Health News:The True 9/11 Hero Story “Color of Honor” Premieres in Germany and Bangladesh: Luciana Lagana Plays the Mother of the Lead and Co-Produces with Blaise Dolcemaschio. 2Health News:The True 9/11 Hero Story “Color of Honor” Premieres in Germany and Bangladesh: Luciana Lagana Plays the Mother of the Lead and Co-Produces with Blaise Dolcemaschio. 3Health News:Coral Gables Florida Gets Ready to Be Lice-Free with Lice Troopers 2Health News:Federal Court Overseeing Thousands of Transvaginal Mesh Lawsuits Set to Convene Joint Status Conference for All Litigations, Bernstein Liebhard LLP Reports 2Health News:Federal Court Overseeing Thousands of Transvaginal Mesh Lawsuits Set to Convene Joint Status Conference for All Litigations, Bernstein Liebhard LLP Reports 3Health News:Federal Court Overseeing Thousands of Transvaginal Mesh Lawsuits Set to Convene Joint Status Conference for All Litigations, Bernstein Liebhard LLP Reports 4Health News:Every Year Four Million Emergency Department Visits Result from Accidents Involving Bone Trauma 2Health News:Every Year Four Million Emergency Department Visits Result from Accidents Involving Bone Trauma 3Health News:Every Year Four Million Emergency Department Visits Result from Accidents Involving Bone Trauma 4
... ... major business industries choose Extended Validation SSL to increase trust and confidence in online ... London, ... longest established Certification Authorities (CA) and specialists in SSL Certificate security, has today announced ...
... ... provide Aprima EHR/PM solutions to Missouri and Kansas medical practitioners , ... DALLAS, TX (Vocus) March 23, 2010 ... practice management (PM) and revenue cycle management solutions for medical practices, today announced a ...
... ... month by donating book sets aimed at combatting child sex abuse. , ... Boston, MA (PRWEB) March 24, 2010 -- On ... to the first 50 people who place an order at www.endchildmolestation.com . The ...
... ... has launched StrengthofUs.org, a new online community where young adults living with mental health concerns ... from ages 18 to 25. , ... Arlington, VA (PRWEB) March 23, 2010 -- The National Alliance on Mental Illness ...
... March 23 "Democrats defending the new Obama health law claim that a woman,s right to abortion is protected. That,s not possible ... New York State.  "Either your body is protected from government interference or it isn,t." , ... ... ...
... assist seniors with aging at home, announced this week a recent expansion of its site,s resources and content. , ... , , ... ... ...
Cached Medicine News:Health News:GlobalSign EV SSL Certificates Secure Leading World Wide Brands 2Health News:GlobalSign EV SSL Certificates Secure Leading World Wide Brands 3Health News:GlobalSign EV SSL Certificates Secure Leading World Wide Brands 4Health News:Aprima and CyTek Corporation Partner to Provide Electronic Health Records to Physician Practices, 2Health News:Author Donates Books To End Child Molestation 2Health News:NAMI Launches Social Networking Site for Young Adults: Mental Health, Finances, Relationships, Music and More 2Health News:NAMI Launches Social Networking Site for Young Adults: Mental Health, Finances, Relationships, Music and More 3Health News:Betsy McCaughey: Government Control of Your Body 2Health News:Interactive Web Site Provides Resources So Seniors May Age in Place 2Health News:Interactive Web Site Provides Resources So Seniors May Age in Place 3Health News:Interactive Web Site Provides Resources So Seniors May Age in Place 4
... Siemens introduces the AXIOM Artis ... first biplane magnetic navigation system equipped ... both planes, which is uniquely capable ... of catheter-based procedures to facilitate increased ...
... AXIOM Artis dTC is a versatile ... the cardiology department from preparation to ... interventional procedures. With AXIOM Artis dTC, your ... the cardiology department that leaves you free ...
The AXIOM Artis TC is ideal for applications above and beyond standard cardioangiography, and features:, Single plane C-Arm, ceiling-mounted, Full-size CCD camera, ...
... AXIOM Artis BC is a ... system architecture ideal for cardiological ... and ergonomic architecture enables you ... configuration to focus on:, ...
Medicine Products: