Navigation Links
Adding INSPRA® (eplerenone) to Standard Therapy Significantly Reduces the Risk of CV Mortality and Morbidity in Patients With Chronic Heart Failure With Mild Symptoms, Study Shows
Date:11/14/2010

able patients with left ventricular (LV) systolic dysfunction (ejection fraction less than or equal to 40%) and clinical evidence of congestive heart failure (CHF) after an acute myocardial infarction (MI).  Eplerenone is also indicated for the treatment of hypertension.  Eplerenone may be used alone or in combination with other antihypertensive agents.

Eplerenone is contraindicated in all patients with serum potassium greater than 5.5 mEq/L at initiation, creatinine clearance less than or equal to 30 mL/min, or concomitant administration of strong CYP3A4 inhibitors.  Eplerenone is also contraindicated for the treatment of hypertension in patients with type 2 diabetes with microalbuminuria, serum creatinine greater than 2.0 mg/dL in males or greater than 1.8 mg/dL in females, creatinine clearance less than 50 mL/min, or concomitant administration of potassium supplements or potassium sparing diuretics.

Serum potassium should be measured before initiating eplerenone therapy, within the first week, and at one month after the start of treatment or dose adjustment.  Serum potassium should be assessed periodically thereafter, especially in patients at risk for the development of hyperkalemia such as elderly patients with renal insufficiency and patients with type 2 diabetes and microalbuminuria.

Most common adverse reactions (greater than 2% and more frequent than with placebo) in patients with CHF Post-MI: hyperkalemia and increased creatinine.  Most common adverse reactions (greater than or equal to 2% and more frequent than with placebo) in hypertensive patients: dizziness, diarrhea, coughing, fatigue and flu-like symptoms.

In the EU, eplerenone is indicated to reduce the risk of cardiovascular mortality and morbidity in stable patients with left ventricular dysfunction (LVEF less than or equal to 40%) and clinical evidence of heart failure after recent myocardial infarction.  

In Japan, eplerenone is ap
'/>"/>

SOURCE Pfizer Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine technology :

1. Adding Lantus® to Oral Antidiabetic Drug Therapy Further Reduced Blood Sugar in Patients with Type 2 Diabetes
2. TechniScan Announces Adding Another Center to Worldwide Clinical Trials for New Breast Imaging System
3. BrainCells Inc. Broadens Scientific Advisory Board Adding Drs. Edward Scolnick and David Holtzman
4. TMS Health Continues to Expand - Adding Over 60 New Jobs at Boca Raton Headquarters
5. Adding Steroid Drug to MS Treatment May Reduce Disease Activity
6. Adding Breast Ultrasound Screening to Mammography Reveals Cancers not Seen on Mammography Alone in Women at Increased Risk for Breast Cancer
7. New Data Examines the Effect of Adding a Statin to Optimized Treatment for Patients with Advanced Heart Failure
8. Substandard and Counterfeit Antimalarial Drugs in Ghana Discovered by Cooperative Program of USP, Ghana Food and Drugs Board
9. China Shenghuo Receives Notice from NYSE Amex LLC Regarding Listing Standards
10. Update: Clinical Trial Establishes Catheter-based Aortic Valve Replacement As New Standard of Care for Patients Who Cannot Undergo Surgery
11. Clinical Trial Establishes Catheter-Based Aortic Valve Replacement as New Standard of Care for Patients Who Cannot Undergo Surgery
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2015)... April 17, 2015 Nonin Medical, a global ... and Chief Operating Officer Steve Bucholz will ... is expanding his role as Chief Executive Officer. In ... Chief Technology Officer. Operations will transition to David ... Bucholz has been instrumental to Nonin Medical,s growth," ...
(Date:4/17/2015)... DUBLIN , Apr. 17, 2015 Research and ... addition of the "Medical Equipment Rental and Leasing ... offering. This report analyzes the worldwide markets ... The report provides separate comprehensive analytics for the US, ... , and Rest of World. Annual estimates ...
(Date:4/17/2015)... DETROIT , April 17, 2015  In ... poverty, the infant mortality rate is two and one half ... live births. Nearly 6 of 10 infants that die in ... care.  These are sobering statistics that Covenant Community Care, a ... Metro Detroit, is poised to change thanks to a charitable ...
Breaking Medicine Technology:Nonin Medical's Philip Isaacson Expands CEO Role; President and COO Steve Bucholz to Retire May 1 2Medical Equipment Rental and Leasing Market 2015-2020 - Global Strategic Business Report - Healthcare Spending Slowdown Bodes Well for Medical Equipment Leasing 2Covenant Community Care to Receive Donated SONIMAGE P3 Handheld Ultrasound from Konica Minolta Medical Imaging 2Covenant Community Care to Receive Donated SONIMAGE P3 Handheld Ultrasound from Konica Minolta Medical Imaging 3Covenant Community Care to Receive Donated SONIMAGE P3 Handheld Ultrasound from Konica Minolta Medical Imaging 4
... ROCHESTER, N.Y., March 23 A type of brain cell ... few ways in which the human brain differs fundamentally from ... published their findings as the cover story in the March ... the University of Rochester Medical Center found that ...
... WASHINGTON, March 23 Since 1993, when the PLCO trial ... with eager anticipation, as have others. The initial report of ... comparable European trial -- published last week in the New ... , * The studies offer conflicting evidence about ...
Cached Medicine Technology:Astrocytes Help Separate Man From Mouse 2Astrocytes Help Separate Man From Mouse 3Astrocytes Help Separate Man From Mouse 4Astrocytes Help Separate Man From Mouse 5A Joint Statement From America's Prostate Cancer Advocacy, Education, and Support Organizations 2A Joint Statement From America's Prostate Cancer Advocacy, Education, and Support Organizations 3
(Date:4/18/2015)... Carinsurancesavings.biz has released a new blog post ... during Spring. , Spring can be a great ... make sure they compare the newest policies before deciding ... more about Spring car insurance offers by reading the ... are becoming more and more popular. Many insurance brokerage ...
(Date:4/18/2015)... 2015 "I recognized the need for ... facilities," said an inventor from Cincinnati, Ohio. "This need ... He developed the Slyde Door to offer an alternative ... facilities. It provides convenient storage space for an evacuation ... available for patients. , This offers added peace ...
(Date:4/18/2015)... YORK (PRWEB) April 18, 2015 Review ... are hosting a ‘Strategies for Success’ program for cataract ... Surgeons meeting in San Diego, where eye surgeon Jeffrey ... for this invitation-only event. Dr. Martin is the Managing ... Review of Ophthalmology chose Dr. Martin to lead this ...
(Date:4/18/2015)... Lowcostcarinsuranceprice.com has released a new blog post ... auto insurance prices . , Drivers who live ... may have to pay more for auto insurance plans ... can also offer protection against vehicle theft. , ... on a single website: http://lowcostcarinsuranceprice.com/ . Drivers ...
(Date:4/18/2015)... NC (PRWEB) April 18, 2015 Patients ... risk of developing mesothelioma later in life, but the ... from mesothelioma that is unrelated to radiation. Surviving Mesothelioma ... on its website. Click here to read it ... Australia compared the cases of 45 patients who had ...
Breaking Medicine News(10 mins):Health News:Auto Insurance Plans Are Cheaper During Spring! 2Health News:Dr. Jeffrey Martin Invited to Share Latest Breakthroughs in Cataract Care During Roundtable Discussion at National 2015 ASCRS Meeting In San Diego 2Health News:High Rates Of Car Theft Can Have An Impact on Auto Insurance Prices! 2Health News:New Study Examines Relationship Between Radiation for Hematologic Cancers and Development of Mesothelioma, According to Surviving Mesothelioma 2
... , VIENNA, July 14 Eating ... physical activity may help preserve our memory and thinking abilities as ... Association 2009 International Conference on Alzheimer,s Disease (ICAD 2009) in Vienna. ... http://www.newscom.com/cgi-bin/prnh/20090529/ICADLOGO ) , ...
... , , , , ... world,s largest and only multi-media diabetes resource, announced today that Nick Jonas of ... his four-year challenge with type 1 diabetes. It will air on ... CNBC. , , Jonas has succeeded in integrating ...
... , , SCHAUMBURG, Ill., July 14 ... on vitamin D after an updated review of the increasing body of ... , , The Academy continues to ... supplements, and not from unprotected exposure to ultraviolet (UV) radiation from the ...
... , NEW ORLEANS, July 14 Ochsner Medical ... transplant in Louisiana, and one of only a handful in the ... make living-donor kidney transplants easier on the donor by using smaller ... performed the operation in July 2009 with successful outcomes for the ...
... -- A new Mayo Clinic study found that ... better at predicting who will develop Alzheimer,s disease ... of information to aid in the identification and early treatment ... will be presented at the Alzheimer,s Association International Conference on ...
... deaths attributed to smothering and overlaying, by either a ... or Sudden Infant Death Syndrome (SIDS). These deaths would ... infanticide, because SIDS had not yet been identified, according ... Arizona, USA. Her findings (1) are published online this ...
Cached Medicine News:Health News:A 'Heart Healthy' Diet and Ongoing, Moderate Physical Activity May Protect Against Cognitive Decline as We Age 2Health News:A 'Heart Healthy' Diet and Ongoing, Moderate Physical Activity May Protect Against Cognitive Decline as We Age 3Health News:A 'Heart Healthy' Diet and Ongoing, Moderate Physical Activity May Protect Against Cognitive Decline as We Age 4Health News:A 'Heart Healthy' Diet and Ongoing, Moderate Physical Activity May Protect Against Cognitive Decline as We Age 5Health News:A 'Heart Healthy' Diet and Ongoing, Moderate Physical Activity May Protect Against Cognitive Decline as We Age 6Health News:A 'Heart Healthy' Diet and Ongoing, Moderate Physical Activity May Protect Against Cognitive Decline as We Age 7Health News:A 'Heart Healthy' Diet and Ongoing, Moderate Physical Activity May Protect Against Cognitive Decline as We Age 8Health News:Nick Jonas Opens Up About His Diabetes In Exclusive TV Interview July 19th, 2009 on dLife 2Health News:American Academy of Dermatology Issues Updated Position Statement on Vitamin D 2Health News:American Academy of Dermatology Issues Updated Position Statement on Vitamin D 3Health News:American Academy of Dermatology Issues Updated Position Statement on Vitamin D 4Health News:Ochsner 1st in Louisiana to use Robotics in Living-Donor Kidney Transplant for Faster Recovery 2Health News:Mayo Clinic study continues to refine most effective methods to predict Alzheimer's disease 2
Stratasis Urethral Sling is intended for implantation to reinforce soft tissues where weakness exists. Supplied sterile in peel-open packages. Intended for one-time use....
Used for retrograde pyelogram. The tip configuration occludes the ureteral orifice and stabilizes the catheter by temporarily wedging in the orifice. Supplied sterile in peel-open packages. Intended ...
Used for drainage and retrograde pyelogram. Supplied sterile in peel-open packages. Intended for one-time use....
Used for directing a flexible tipped wire guide in the ureter. The angled tip allows passage of the catheter past a ureteral stone in preparation for E.S.W.L. Supplied sterile in peel-open packages. ...
Medicine Products: