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Adamas Pharmaceuticals presenta datos clínicos positivos para ADS-5102, un tratamiento para la disquinesia inducida por levodopa, en el Congreso Mundial del Parkinson
Date:10/2/2013

los 30 y los 85 años de edad que tenían la enfermedad de Parkinson y estaban experimentando una LID molesta.  Los participantes en el estudio fueron aleatorizados para recibir dosis de 260 mg, 340 mg o 420 mg de ADS-5102 o placebo una vez por la noche durante ocho semanas, con un seguimiento de seguridad de dos semanas. Con el fin de participar en el estudio, los sujetos debían tener una puntuación por lo menos de 2 en la Parte IV, punto 4.2 (impacto funcional de la disquinesia) de la MDS-UPDRS en prueba de detección y el Día 1, y experimentar por lo menos dos intervalos de 30 minutos de período de respuesta a los medicamentos con disquinesia molesta entre las 9 a.m. y las 4 p.m. Las medidas de seguridad abarcaron eventos adversos y pruebas de laboratorio de seguridad de rutina que una comisión independiente de supervisión de datos revisó durante el estudio.

Acerca de ADS-5102 (Nurelin™)
ADS-5102 es una formulación patentada, en investigación, de acción prolongada de amantadina HCl en desarrollo para el tratamiento de trastornos del sistema nervioso central (SNC), incluida la LID en la enfermedad de Parkinson. Administrada una vez por la noche a la hora de acostarse, ADS-5102 proporciona un lento incremento inicial en la concentración de amantadina en el plasma, dando lugar a una concentración alta en el plasma durante el día, cuando la LID puede ser molesta, y a una baja concentración durante la noche.  Adamas está investigando si el novedoso perfil farmacocinético y la baja concentración de amantadina en el plasma durante la noche pueden reducir el insomnio, los trastornos del sueño y los sueños vívidos ocasionalmente asociados con la amantadina.  ADS-5102 se está investigando en estudios clínicos en dosis una vez por la noche 1.3 a 2.1 veces más que la dosis de 100 mg dos veces al día usada general
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SOURCE Adamas Pharmaceuticals, Inc.
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