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Adamas Pharmaceuticals presenta datos clínicos positivos para ADS-5102, un tratamiento para la disquinesia inducida por levodopa, en el Congreso Mundial del Parkinson
Date:10/2/2013

DRS (Partes I, II y III).  Los eventos adversos reportados en este estudio fueron típicamente de benignos a moderados en severidad y congruentes con la enfermedad de Parkinson y el conocido perfil de seguridad de amantadina. No hubo diferencia con el placebo en la incidencia de eventos adversos relacionados con el sueño.

Hoy se presentaron datos del estudio de Fase 2/3 en un cartel titulado "Seguridad y eficacia de ADS-5102 en la disquinesia inducida por la levodopa (Estudio EASED)" (Extracto #1311.00) a las 11:30 a.m., hora del Este, en el Congreso Mundial del Parkinson en Montreal, Canadá. El cartel también ha sido seleccionado para un "Recorrido Guiado del Cartel" entre las 5:15 y las 6:45 p.m., hora del Este. Pueden verse más detalles de los resultados del estudio EASED en el sitio web de Adamas.

Acerca del estudio EASED™
El estudio EASED fue una prueba clínica aleatorizada, doble ciego, controlada con placebo en la que participaron 83 sujetos con la enfermedad de Parkinson en 31 sitios de estudio en los Estados Unidos. El análisis de eficacia primaria del estudio comparó ADS-5102 con el placebo para reducción en la LID en ocho semanas, evaluado según la Escala Unificada para la Evaluación de la Disquinesia (UDysRS).  Las medidas del resultado de eficacia secundaria abarcaron cambios en un diario estandarizado de la PD, entre ellos: período de respuesta a los medicamentos sin disquinesia molesta; estado clínico general de la PD, evaluado por la MDS-Escala Unificada para la Evaluación de la Enfermedad de Parkinson (MDS-UPDRS); y fatiga medida usando la Escala de Severidad de la Fatiga. La prueba EASED también abarcó una evaluación de la respuesta a la dosis por ADS-5102. En el estudio participaron sujetos masculinos y femeninos entre
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SOURCE Adamas Pharmaceuticals, Inc.
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