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Adamas Pharmaceuticals' TCAD Therapy Demonstrates Broad Spectrum Activity Against Susceptible and Resistant Strains of Influenza in Animal Models
Date:3/15/2010

"Through our comprehensive preclinical program, we have demonstrated the broad spectrum effect of TCAD therapy with the potential to overcome baseline resistance while imposing a high genetic barrier to impede the generation of resistant influenza virus strains," said Gregory T. Went, PhD., CEO and Chairman of Adamas Pharmaceuticals. "This accomplishment is a critical foundation for our clinical program and our long-term commitment to providing a solution that meets the needs of physicians in treating patients with influenza infection."

About TCAD Therapy

Adamas is pioneering triple combination antiviral drug (TCAD) therapy for influenza, which is designed to inhibit viral replication at multiple points in the virus proliferation pathway. TCAD therapy includes Adamas' investigational proprietary fixed-dose combination of amantadine and ribavirin, to be administered adjunctively with a neuraminidase inhibitor such as Tamiflu ® (oseltamivir phosphate, Roche).

Preclinical data indicate that the in vitro combination of these drugs, each with independent mechanisms of action, act synergistically to provide a much higher level of antivira
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SOURCE Adamas Pharmaceuticals, Inc.
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