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Adamas Pharmaceuticals' TCAD Therapy Demonstrates Broad Spectrum Activity Against Susceptible and Resistant Strains of Influenza in Animal Models
Date:3/15/2010

o the efficacy of TCAD against amantadine-resistant pandemic 2009 H1N1 virus.

In additional in vitro experiments, influenza virus was replicated in the presence of clinically relevant concentrations of single agents, double combinations and TCAD therapy over a 15 day time period.  Treatment with the single agents and double combination resulted in the complete breakthrough of resistant viruses, while triple therapy effectively impeded the development of resistance.

The Need for Broad Spectrum Antiviral Therapy

According to the World Health Organization, more than 17,000 deaths occurred in the U.S. alone this flu season due to the pandemic novel H1N1 virus, highlighting the need for an effective broad spectrum antiviral therapy, especially for patients severely ill with influenza for whom current antivirals are ineffective. The greatest impact of influenza infection is felt in at-risk groups especially vulnerable to infections such as patients with cardiovascular disease, diabetes, asthma and those who are immunocompromised. These individuals are at a higher risk of hospitalization and ICU admission, as well as other complications related to influenza. Resistance to at least one class of antiviral drugs in all circulating strains complicates the diagnosis and treatment of flu.


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SOURCE Adamas Pharmaceuticals, Inc.
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