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Adamas Pharmaceuticals' TCAD Therapy Demonstrates Broad Spectrum Activity Against Susceptible and Resistant Strains of Influenza in Animal Models
Date:3/15/2010

"With these data, Adamas and its collaborators continue to build a strong case for triple combination therapy in influenza," said Richard J. Whitley, M.D., Professor of Pediatrics, Microbiology and Medicine at the University of Alabama at Birmingham. "They have demonstrated that the addition of a third drug is critical to increase the genetic barrier to resistance for influenza. Importantly, the use of a triple drug combination also results in a substantial increase in efficacy over double combinations at clinically relevant concentrations, allowing the continued use of drugs to which the virus has evolved resistance. If validated in human studies, TCAD could fill a significant gap in the treatment of influenza."

About the in vivo and in vitro Studies

At the meeting yesterday, Dr. Jack Nguyen of Adamas presented data from in vivo studies demonstrating that TCAD is highly efficacious against susceptible H5N1 and resistant pandemic 2009 H1N1 in mouse treatment models in which physiologic concentrations of oseltamivir provided little or no protection. These data confirmed the increase in potency of TCAD observed in vitro, showing that TCAD is significantly more efficacious than double combinations, resulting in greater than 90% survival in the treated mice. Moreover, amantadine contributed t
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SOURCE Adamas Pharmaceuticals, Inc.
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