Navigation Links
Adamas Pharmaceuticals' TCAD Therapy Demonstrates Broad Spectrum Activity Against Susceptible and Resistant Strains of Influenza in Animal Models
Date:3/15/2010

EMERYVILLE, Calif., March 15 /PRNewswire/ -- Adamas Pharmaceuticals, Inc., a privately held company, announced today results from in vivo animal studies and in vitro tests demonstrating that its triple combination antiviral drug (TCAD) therapy is superior relative to double combinations and monotherapy against multiple strains of pandemic and avian influenza viruses. Results of these studies were presented Sunday evening in an oral session at the XII International Symposium on Respiratory Viral Infections being held in Taipei.

Currently, virtually all influenza A viruses are resistant to at least one approved antiviral and mounting evidence suggests that monotherapy leads to single and multi-drug resistance, creating a pressing need for new influenza therapies.

Data presented by Adamas at the conference demonstrates that the triple combination of amantadine, ribavirin, and oseltamivir is highly active against susceptible and resistant influenza A virus infection in mouse models. In addition, the triple combination was shown to suppress the generation of resistant influenza A viruses in vitro. These data confirm findings from recently published in vitro studies (PLoS One, AAC), and answer fundamental questions about the viral kinetics of susceptible and resistant strains of the influenza A virus in response to TCAD.

"With these data, Adamas and its collaborators continue to build a strong case for triple combination therapy in influenza," said Richard J. Whitley, M.D., Professor of Pediatrics, Microbiology and Medicine at the University of Alabama at Birmingham. "They have demonstrated that the addition of a third drug is critical to increase the genetic barrier to resistance for influenza. Importantly, the use of a triple drug combination also results in a substantial increase in efficacy over double combinations at clinically relevant concentrations, allowing the continued use of drugs to which the virus has evolved resistance. If validated in human studies, TCAD could fill a significant gap in the treatment of influenza."

About the in vivo and in vitro Studies

At the meeting yesterday, Dr. Jack Nguyen of Adamas presented data from in vivo studies demonstrating that TCAD is highly efficacious against susceptible H5N1 and resistant pandemic 2009 H1N1 in mouse treatment models in which physiologic concentrations of oseltamivir provided little or no protection. These data confirmed the increase in potency of TCAD observed in vitro, showing that TCAD is significantly more efficacious than double combinations, resulting in greater than 90% survival in the treated mice. Moreover, amantadine contributed to the efficacy of TCAD against amantadine-resistant pandemic 2009 H1N1 virus.

In additional in vitro experiments, influenza virus was replicated in the presence of clinically relevant concentrations of single agents, double combinations and TCAD therapy over a 15 day time period.  Treatment with the single agents and double combination resulted in the complete breakthrough of resistant viruses, while triple therapy effectively impeded the development of resistance.

The Need for Broad Spectrum Antiviral Therapy

According to the World Health Organization, more than 17,000 deaths occurred in the U.S. alone this flu season due to the pandemic novel H1N1 virus, highlighting the need for an effective broad spectrum antiviral therapy, especially for patients severely ill with influenza for whom current antivirals are ineffective. The greatest impact of influenza infection is felt in at-risk groups especially vulnerable to infections such as patients with cardiovascular disease, diabetes, asthma and those who are immunocompromised. These individuals are at a higher risk of hospitalization and ICU admission, as well as other complications related to influenza. Resistance to at least one class of antiviral drugs in all circulating strains complicates the diagnosis and treatment of flu.

"Through our comprehensive preclinical program, we have demonstrated the broad spectrum effect of TCAD therapy with the potential to overcome baseline resistance while imposing a high genetic barrier to impede the generation of resistant influenza virus strains," said Gregory T. Went, PhD., CEO and Chairman of Adamas Pharmaceuticals. "This accomplishment is a critical foundation for our clinical program and our long-term commitment to providing a solution that meets the needs of physicians in treating patients with influenza infection."

About TCAD Therapy

Adamas is pioneering triple combination antiviral drug (TCAD) therapy for influenza, which is designed to inhibit viral replication at multiple points in the virus proliferation pathway. TCAD therapy includes Adamas' investigational proprietary fixed-dose combination of amantadine and ribavirin, to be administered adjunctively with a neuraminidase inhibitor such as Tamiflu ® (oseltamivir phosphate, Roche).

Preclinical data indicate that the in vitro combination of these drugs, each with independent mechanisms of action, act synergistically to provide a much higher level of antiviral activity than single or double drug combination therapies. In preclinical studies to date, TCAD therapy also has been found to provide greater antiviral activity across more than 13 strains of seasonal, pandemic, and avian influenza A (H1N1, H3N2 and H5N1) virus, including six amantadine resistant strains and two oseltamivir-resistant strains. TCAD therapy for influenza A is currently being investigated in a Phase 2 human clinical study.

About Adamas

Adamas is an emerging pharmaceutical company focused on developing small molecule Advantaged Therapeutics to treat neurological and infectious diseases, including influenza A, the cause of the current flu pandemic. Adamas' approach to product development is to identify unmet needs where existing drugs can be developed as optimized combination drug therapies to increase safety, efficacy and compliance, thus improving upon the standard of care. Adamas is headquartered in Emeryville, California, with operations in Bangalore, India. For more information about Adamas, please visit www.adamaspharma.com.

SOURCE Adamas Pharmaceuticals, Inc.

Back to top

RELATED LINKS
http://www.adamaspharma.com

'/>"/>

SOURCE Adamas Pharmaceuticals, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Related medicine technology :

1. Adamas Pharmaceuticals Announces In Vitro Data Demonstrating TCAD Therapy is More Potent Than Double Combinations or Monotherapy Against Drug-Resistant Flu Strains
2. In Vitro Study of Adamas Pharmaceuticals Triple Combination Antiviral Drug Therapy Shows Activity Against Drug-Resistant Influenza Viruses
3. Adamas Pharmaceuticals Signs CRADA With U.S. Navy to Conduct Preclinical Studies of Triple-Combination Antiviral Drug Therapy for Influenza A, Including the Novel H1N1 Pandemic Strain
4. Endo Pharmaceuticals Announces Appointment of New Chief Operating Officer
5. FDA Grants Bayer HealthCare Pharmaceuticals Orphan Drug Designation for Investigational Ciprofloxacin Dry Powder Inhaler for the Treatment of Cystic Fibrosis
6. Vanda Pharmaceuticals Announces Date of Annual Meeting of Stockholders
7. Lotus Pharmaceuticals Reports Groundbreaking Ceremony
8. Keryx Biopharmaceuticals to Present at the 22nd Annual ROTH OC Growth Stock Conference
9. Cumberland Pharmaceuticals Reports 24% Increase in Net Revenue With Full Year 2009 Financial Results
10. Anadys Pharmaceuticals to Present at the ROTH OC Growth Stock Conference
11. Jury Verdict Against Novartis Pharmaceuticals For Retaliating Against Drug Sales Rep Who Took Maternity Leave
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/9/2016)... LONDON , Feb. 9, 2016 Hearing ... amount of sound energy transmitted to the inner ear. ... and hearing bands. These devices are recommended for users ... eight hours. Earplugs refer to HPD that are inserted ... attenuation earplugs are designed to provide more natural sound ...
(Date:2/9/2016)... -- Increasingly, health care professionals are enhancing patient care and ... With the Vios Monitoring System from Vios Medical, health ... problems before they become serious by continuously tracking and ... the United States . --> ... --> The Vios Monitoring System connects patient-worn sensors, ...
(Date:2/9/2016)... -- The new report "Global Anti-Bacterial Drugs Market Assessment & Forecast: ... reveals that the North America continued to ... 2014 that translated into revenues worth US$ 16,907.3 million. ... Asia-Pacific , Latin America , ... The global anti-bacterial market is inclined towards North America ...
Breaking Medicine Technology:
(Date:2/9/2016)... Cambridge, MA (PRWEB) , ... February 09, 2016 ... ... Institute (WCRI) compares the workers’ compensation fee schedule rates and Medicare rates for ... medical services covered in the report, Evaluation of the 2015 Fee Schedule ...
(Date:2/9/2016)... ... February 09, 2016 , ... On January 12, 2016 Paul ... appointment after they noticed their furnace not producing any heat. Shortly after entering the ... cracked heat exchanger was leaking dangerous levels of carbon monoxide into the home, at ...
(Date:2/9/2016)... ... February 09, 2016 , ... ... guide will ensure lab personnel have a basic understanding of the techniques they ... protocols. Enhanced understanding will help them reduce waste and rework to create a ...
(Date:2/9/2016)... ... 2016 , ... i2i Systems, an early innovator and developer of population health ... latest KLAS report, Population Health Management 2015: How Far Can Your Vendor Take You? ... management (PHM). The latest KLAS Report, leveraging over 200 user interviews, shines a ...
(Date:2/8/2016)... ... February 08, 2016 , ... ... BASF Human Nutrition into the Food & Beverage and Dietary ... BASF’s channel partner throughout Canada and USA geographies east of the Rocky Mountains ...
Breaking Medicine News(10 mins):