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Adamas Pharmaceuticals' TCAD Therapy Demonstrates Broad Spectrum Activity Against Susceptible and Resistant Strains of Influenza in Animal Models
Date:3/15/2010

EMERYVILLE, Calif., March 15 /PRNewswire/ -- Adamas Pharmaceuticals, Inc., a privately held company, announced today results from in vivo animal studies and in vitro tests demonstrating that its triple combination antiviral drug (TCAD) therapy is superior relative to double combinations and monotherapy against multiple strains of pandemic and avian influenza viruses. Results of these studies were presented Sunday evening in an oral session at the XII International Symposium on Respiratory Viral Infections being held in Taipei.

Currently, virtually all influenza A viruses are resistant to at least one approved antiviral and mounting evidence suggests that monotherapy leads to single and multi-drug resistance, creating a pressing need for new influenza therapies.

Data presented by Adamas at the conference demonstrates that the triple combination of amantadine, ribavirin, and oseltamivir is highly active against susceptible and resistant influenza A virus infection in mouse models. In addition, the triple combination was shown to suppress the generation of resistant influenza A viruses in vitro. These data confirm findings from recently published in vitro studies (PLoS One, AAC), and answer fundamental questions about the viral kinetics of susceptible and resistant strains of the influenza A virus in response to TCAD.


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SOURCE Adamas Pharmaceuticals, Inc.
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