Navigation Links
ActiveSight and CHDI Leverage Fragment-Based Lead Discovery for Huntington Disease Therapies
Date:9/18/2007

SAN DIEGO, Sept. 18 /PRNewswire/ -- ActiveSight, a division of Rigaku Americas Corporation, announced today that it will collaborate on a Fragment-based Lead Discovery (FBLD) Project with CHDI, Inc.

FBLD involves the binding of small compounds, "fragments," to the active sites of protein drug targets. The fragments are much smaller than the compounds used in traditional high-throughput screening (HTS), allowing a more extensive sampling of chemical space with a smaller screening library. Utilizing a Huntington Disease (HD) target chosen by CHDI, ActiveSight will screen fragment libraries using X-ray crystallography to visualize fragments that bind to the target. The fragments will then be linked or grown into larger, drug-like compounds that are thought to be more efficiently binding than compounds resulting from HTS methodologies.

Several compounds based on Fragment-based Lead Discovery (FBLD) methodologies are currently in clinical trials, and the technology is thought to shorten the time from drug target selection to an investigational new drug (IND) filing. The two companies hope that the FBLD collaboration will lead to HD therapies in shorter time periods than conventional lead discovery methods such as HTS.

"ActiveSight's Fragment-based Lead Discovery technologies strengthen our diversified portfolio of parallel drug discovery and development campaigns for Huntington Disease," said Robert Pacifici, Ph.D., CSO of CHDI, Inc. "By obtaining and testing high quality lead compounds quickly, we hope to increase the chances of finding a treatment for HD soon."

ActiveSight's high-throughput structural biology capabilities will facilitate rapid screening of CHDI's HD target with hundreds of drug-like fragments. Automated data collection and structural determination will be facilitated by Rigaku's tools for high-throughput X-ray crystallography, including the ACTOR(TM) crystal-mounting system robot and MIFit+ automated structural determinat
'/>"/>

SOURCE ActiveSight
Copyright©2007 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3

Related medicine technology :

1. Major New Review Supports the Broader Potential of CeNeS COMT Inhibitor Discovery Programme
2. Discoverys KL-4 Surfactant Technology Demonstrates Novel Anti-Inflammatory Properties
3. Discovery Labs Presents Surfaxin and Aerosurf Data At the Pediatric Academic Societies Annual Meeting
4. Major Discovery Raises Prospect of Better Patient Care By Improving Platelet Life Span
5. Clinical Trial Results Suggest Long-Term Treatment Benefit of Tetrabenazine for Chorea Associated with Huntingtons Disease
6. Amarin Reports Top-Line Results of two Phase III Studies of Miraxion in Huntingtons Disease
7. Appendicitis: Evolving Tools to Diagnose a Classic Disease
8. Non-Invasive Diagnostic Tests for Celiac Disease
9. Corgenix Reports New Clinical Data Correlating AtherOx Technology With Vascular Disease
10. AVI BioPharma Partner Cook Medical Announces Completion of Patient Enrollment for APPRAISAL Phase II Clinical Trial for Treatment of Cardiovascular Disease
11. Samaritans Alzheimers Drug Caprospinol Suggests Brain May be Able to Heal From Alzheimers Disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2012)... Vanda Pharmaceuticals Inc. (NASDAQ: VNDA ), ... commercialization of products for central nervous system disorders, ... at the Society for Research on Biological Rhythms ... The first poster entitled Pleiomorphic Expression of ... insight into the challenges faced by individuals suffering ...
(Date:5/22/2012)... ALLEGAN, Mich., May 22, 2012  Perrigo Company ... final approval from the U.S. Food and Drug ... for butoconazole nitrate 2% vaginal cream, the generic ... submit a substantially complete ANDA with a paragraph ... marketing exclusivity. Perrigo is working exclusively with KV Pharmaceutical ...
(Date:5/22/2012)... Generics, a division of Prodigy Health Supplier Corporation ... generic equivalent of the branded drug Camptosar by ... Laboratories to develop a portfolio of oncology products. ... developed through the partnership that will add consistent ... market, which has experienced record levels of shortages ...
Breaking Medicine Technology:Vanda Pharmaceuticals Inc. Presents Scientific Posters at Society for Research on Biological Rhythms (SRBR) Annual Meeting 2Vanda Pharmaceuticals Inc. Presents Scientific Posters at Society for Research on Biological Rhythms (SRBR) Annual Meeting 3Perrigo Receives FDA Approval for Butoconazole Nitrate 2% Vaginal Cream 2Perrigo Receives FDA Approval for Butoconazole Nitrate 2% Vaginal Cream 3GeoVax Initiates Third Site For Therapeutic Testing of Its HIV Vaccine 19815 1GeoVax Initiates Third Site For Therapeutic Testing of Its HIV Vaccine 19815 2GeoVax Initiates Third Site For Therapeutic Testing of Its HIV Vaccine 19815 3GeoVax Initiates Third Site For Therapeutic Testing of Its HIV Vaccine 19815 4ULURU Inc Announces the Engagement of Gilford Securities Incorporated to Serve as the Companys Financial Advisor 18324 1ULURU Inc Announces the Engagement of Gilford Securities Incorporated to Serve as the Companys Financial Advisor 18324 2MAP Pharmaceuticals to Present Data on LEVADEX AE at the 15th Congress of the International Headache Society 18320 1MAP Pharmaceuticals to Present Data on LEVADEX AE at the 15th Congress of the International Headache Society 18320 2MAP Pharmaceuticals to Present Data on LEVADEX AE at the 15th Congress of the International Headache Society 18320 3MAP Pharmaceuticals to Present Data on LEVADEX AE at the 15th Congress of the International Headache Society 18320 4
(Date:5/23/2012)... second edition of Law and the American Health Care ... 2012. Building on its 1997 predecessor, the second edition ... intersection of law and the U.S. health care system. ... a time of unprecedented change in how health care ... of study, the book focuses on how a dramatically ...
(Date:5/23/2012)... of the same kind, thereby triggering skeletal and cardiac ... from the RUB Heart and Diabetes Center NRW in ... an interdisciplinary research project with colleagues from the universities ... Journal of Biological Chemistry . , One ... stabilizing filaments inside of the cells. Different mutations in ...
(Date:5/23/2012)... FRANCISCO The number of viral infections during infancy ... to a new study from researchers in the Netherlands. ... later in childhood, this association was due in part ... in infancy, particularly rhinovirus, are thought to be a ... unclear whether this association is due to the viruses ...
(Date:5/23/2012)... present findings on prostate cancer risk, screening, treatment ... of the American Urological Association May 19-23 in ... to provide expert comment for reporters covering the ... presented and their embargo dates include: , ... surgery hormone therapy , Embargoed until 10:30 a.m. ...
(Date:5/22/2012)... MAYWOOD, Ill. -- Children born with cleft lip, ... medical challenges beyond appearance. , Patients can face ... well as social and psychological challenges, Laura Swibel ... colleagues write in the June 2012 issue of ... "The management of patients with craniofacial syndromes is ...
Breaking Medicine News(10 mins):Health News:Landmark textbook on health care and the US legal system released 2Health News:Aggregating instead of stabilizing: New insights into the mechanisms of heart disease 2Health News:Viral infections in infancy are not associated with wheezing symptoms in later childhood 2Health News:Mayo Clinic urologists present findings at American Urological Association Annual Meeting 2Health News:Mayo Clinic urologists present findings at American Urological Association Annual Meeting 3Health News:Mayo Clinic urologists present findings at American Urological Association Annual Meeting 4Health News:Cleft lip/palate cause much more than cosmetic problems 2
... recent research has found that non-invasive screening in ... percent. Professor Karen Brndum-Nielsen, of the Kennedy Institute, ... of pregnant women with ultrasound early in pregnancy, ... number of children born in Denmark with Down ...
... Elton John performed a free gig in Ukraine to ... the country's capital Kiev, was attended by 200,000 people ... ,The charity performance of the singer whose Aids ... reviews from the people, with some appreciating it and ...
... scientists have developed a new technology that will help ... cost abnormal pregnancies that can lead to miscarriages and ... can be detected even before it can be spotted ... Institute of Health and Family Welfare (NIHFW), a government ...
... to popular film and television character Mr. Bean will soon ... ,Toonz Licensing, Mr Bean's licensing agent for ... Tiger Aspect Productions to bring the globally popular character portrayed ... ,The London based Tiger Aspect Productions is the television producer ...
... officials continue to brood over exhaustive plans for its survival, ... Kashmir's famed Dal Lake - fishing out tonnes of garbage ... large number of people, including foreign and domestic tourists, houseboat ... soft drink bottles and other litter from the lake Monday. ...
... MD, studied the records of all 170 patients hospitalized ... medical center from 2001 to 2005. Study suggests patients ... new or worsening heart problems. ,They found ... or other major heart problem concurrently at the time ...
Other Medicine News:Health News:Non-invasive Screening in Early Pregnancy Halves Down's Syndrome Births 2Health News:New Technology Makes Diagnosis of Abnormal Pregnancy Cheaper 2Health News:Volunteers Remove Garbage from Kashmir's Dal Lake 2Health News:Pneumonia Patients Develop Heart Risks 2
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: