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Active Life's BioDent Reference Point Indenter Validated in Study Published by Osteoporosis Medical Opinion Leaders

SANTA BARBARA, Calif., Jan. 24, 2013 /PRNewswire-iReach/ -- Top Osteoporosis researchers recently published a seminal paper showing that BioDent™ Reference Point Indentation measurements closely relate to toughness, a well-accepted mechanical measure of a bone's ability to resist breaking.   The research was completed at Indiana University / Purdue University in Indiana, led by Drs. David Burr and Max Gallant , and published in BONE, a leading academic journal. 

"A growing body of research has shown that Reference Point Indentation (RPI) data has a strong connection with identifying more and less easily fractured bone when bone density cannot," stated Active Life's Field Applications Scientist, Chris Mazzochi , PhD.  "However, this paper is the first to definitively report how BioDentTM measurements relate to the decades of historical data and knowledge from using conventional mechanical testing machines.  As a result of these and other comparable findings, BioDentTM is quickly becoming the gold standard for measuring the contribution of material properties to whole bone strength."

"Dr. Burr and his team have answered an extremely important question about RPI that will help progress the medical understanding of what causes bones to break in crippling diseases such as osteoporosis," said Active Life's Chief Executive Officer, Davis Brimer .  "Now that researchers know BioDentTM measurements are closely related to toughness as measured by conventional mechanical testers, academic labs and drug companies are more easily integrating BioDentTM into their existing and upcoming research projects and publications."

For more information on the publication visit  and click "Reference-point indentation correlates with bone toughness assessed using whole-bone traditional mechanical testing."

About BioDent™ Reference Point Indenter

The current application for BioDent™ RPI provides researchers with previously impossible means to assess the material properties of bone that resides in a living body (in vivo).  Among researchers it is generally understood that bone strength, the ability of a bone to resist breaking, depends on three things: 

  • How much bone material there is (bone mass/bone mineral density),
  • How well the bone material is put together (bone structure), and
  • How good that bone material is (bone material properties)

About Active Life Scientific, Inc.

Active Life Scientific, Inc. develops life science research and diagnostic tools that measure biological tissue quality.   These tools utilize novel biomarkers linked to the physical properties of tissues, such as how fibrous, elastic, or strong a tissue is.  The Company's products are based on world renowned inventor Dr. Paul Hansma 's latest breakthrough, Reference Point Indentation (RPI), with the unrivaled ability to quantify the quality of tissues that reside inside the living body (in vivo).  Active Life's flagship product, BioDent™, is utilized by key researchers who investigate and monitor diseased tissues and develop new treatments.  The Company currently supports bone research and is actively expanding applications for other tissues.  Active Life's mission is to provide life science and diagnostic tools that quantify tissue quality to enable accelerated drug development, cost-effective health care, and a better quality of life.

Media Contact: Davis Brimer Active Life Scientific, Inc., +1.805.770.2600 x101,

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