Navigation Links
Acologix Presents Preclinical Data on Cartilage Regeneration by AC-100 at the OARSI 2007 World Congress on Osteoarthritis
Date:12/7/2007

HAYWARD, Calif., Dec. 7 /PRNewswire/ -- Acologix, Inc., a privately held biopharmaceutical company, today announced preclinical study results demonstrating that AC-100, its novel synthetic peptide derived from an endogenous human protein produced by bone and dental cells, promoted cartilage regeneration in an animal model. The data was presented by Dr. Catherine Middleton-Hardie at the Osteoarthritis Research Society International (OARSI) 2007 World Congress on Osteoarthritis in Fort Lauderdale, Florida during the poster sessions.

In this study, goats with an osteochondral femoral condylar (knee cartilage) defect were used to evaluate the effects of AC-100 on cartilage regeneration. Cylindrical defects were created in the knee cartilage and were filled with a collagen sponge containing AC-100 at two different doses or a collagen sponge soaked in saline (control group). Post-operative treatments included intra-articular injections of the test articles into the operated knee joint at weeks one, two and three post surgery. Cartilage regeneration was evaluated in one group after 84 days and 168 days in another group.

The results demonstrated that the application of AC-100 dose dependently promoted cartilage defect repair. The groups treated with the higher dosage of AC-100 had greater healing outcome scores than the saline control groups. As there was no evidence of an inflammatory response, AC-100 demonstrated a favorable safety profile in the study.

These results follow a reported Phase II clinical trial that demonstrated AC-100 stimulates the formation of new dentin (the hard tissue of teeth that protects the tooth pulp and supports the outer enamel) when applied directly to tooth defects (prepared cavities).

"We are very pleased to see this type of response to AC-100 in such a challenging model. This is the first demonstration of AC-100 to promote cartilage repair. These findings are consistent with previous studies where AC-100 ha
'/>"/>

SOURCE Acologix, Inc.
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Genaera Corporation Presents Interim Phase 1 Data for Obesity Compound Trodusquemine (MSI-1436) at IBC Conference
2. EntreMed Presents Data for Phase 2 Study of MKC-1 in Metastatic Breast Cancer
3. Pharmasset Presents R7128 Phase 1 Single Ascending Dose Study in Healthy Volunteers
4. Anadys Pharmaceuticals Presents Preclinical Results on ANA598, a Non-Nucleoside Inhibitor of the NS5B Polymerase, at the 14th International Symposium on Hepatitis C Virus and Related Viruses
5. CEL-SCI Presents Data for CEL-1000 as a Vaccine Adjuvant with Recombinant Hepatitis B Virus Protein
6. Ardea Biosciences, Inc. Presents Results of Phase 1 Studies of RDEA806, a Novel NNRTI for HIV, at 47th ICAAC
7. Targanta Presents First Data Demonstrating In Vitro Activity and In Vivo Efficacy of Prodrugs in Osteomyelitis Models
8. Wyeth Presents Phase 3 Fracture Data for Bazedoxifene, an Investigational Therapy for Osteoporosis
9. Aegerion Pharmaceuticals, Inc. Presents Final Results of Phase II Clinical Trials for AEGR-733 at Drugs Affecting Lipid Metabolism (DALM) 2007 Conference
10. Surface Logix Presents Positive Phase 1 Repeat-Dose Trial Data on SLx-4090 at The 16th International Symposium on Drugs Affecting Lipid Metabolism
11. Wyeth Presents New Phase 3 Data and Updates Regulatory Timing for NDA Filing of Bazedoxifene/Conjugated Estrogens
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/15/2014)... 15, 2014 Massachusetts General Hospital (MGH), the ... ) announced today that they have launched a ... therapeutic targets and develop novel therapies for inflammatory ... millions worldwide. The MGH-Broad-Amgen collaboration brings together scientists ...
(Date:1/15/2014)... 2014  Manufacturers, suppliers and distributors of innovative medical-related ... their most important business assets, intellectual property (IP). ... Because of the highly-competitive nature of the ... the most litigious industry sectors of cases involving ...
(Date:1/15/2014)... Therapeutics, Inc. (Nasdaq: ECTE ) ("Echo"), a ... a non-invasive, wireless continuous glucose monitoring system, today announced ... Interim CEO of Echo Therapeutics, will present at "TEN", ... Mr. Doman will make a corporate presentation ...
Breaking Medicine Technology:Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 2Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 3Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 4Intellectual Property Insurance for Medical-related Products and Services 2Echo Therapeutics to Present at the Noble Financial Capital Markets' Tenth Annual Equity Conference 2Echo Therapeutics to Present at the Noble Financial Capital Markets' Tenth Annual Equity Conference 3
... Ohio, Sept. 13 AultCare has been using ... partnership with Cardiocom, released a white paper entitled, ... The paper describes the structure of the ... patient. Improved patient self-management has resulted in measurable ...
... 2010 Arena Pharmaceuticals, Inc. (Nasdaq: ARNA ... and webcast on Friday, September 17, 2010, at 7:00 ... US Food and Drug Administration (FDA) Endocrinologic and Metabolic ... meet on September 16, 2010, to review the lorcaserin ...
Cached Medicine Technology:AultCare/Cardiocom® White Paper Shows Telehealth Services Reduce ER Visits and Inpatient Stays for Patients 2Arena Pharmaceuticals to Host Conference Call and Webcast Following Lorcaserin FDA Advisory Committee Meeting 2Arena Pharmaceuticals to Host Conference Call and Webcast Following Lorcaserin FDA Advisory Committee Meeting 3
(Date:4/17/2014)... April 17, 2014 By discovering a new mechanism ... a stroke, researchers at UC Irvine and the Salk ... may limit or prevent stroke-induced brain damage. , A ... cause of death and primary reason for disability in ... a stroke and lets blood-borne material into the brain, ...
(Date:4/17/2014)... online has the potential to ward off depression among ... research published online in The Journals of ... . In the article " Internet Use and Depression ... Longitudinal Analysis ," the authors report that Internet use ... percent among their study sample. , Late-life depression ...
(Date:4/17/2014)... N.C. April 17, 2014 Meaningful long-term ... advanced cancer of the abdomen when treated with ... according to a first-of-its-size analysis by physicians at ... Baptist has the largest reported, single-center experience with ... A. Levine, M.D., and analysis of 20 years, ...
(Date:4/17/2014)... of Canadians surveyed said they would participate in public ... of genetic conditions, only 80 per cent said they ... sequence their newborns, genomes.,Most newborns in North America have ... two of life in which a tiny amount of ... about five to 54 conditions, depending on the state ...
(Date:4/17/2014)... Researchers from LSTM have called for more research ... coinfection in children in sub-Saharan Africa. In a ... LSTM,s Professor Russell Stothard, working with colleagues in ... Western Reserve University, in Cleveland Ohio, University of ... previous research into the joint burden of HIV/AIDS ...
Breaking Medicine News(10 mins):Health News:Study IDs new cause of brain bleeding immediately after stroke 2Health News:Internet use may cut retirees' depression 2Health News:20 years of data shows treatment technique improvement for advanced abdominal cancer 2Health News:Researcher looks at public perceptions around newborn testing 2Health News:Researcher looks at public perceptions around newborn testing 3Health News:More research called for into HIV and schistosomiasis coinfection in African children 2
... Magazine and Home Instead Senior Care Launch Third Annual ... ... support, FAIRFIELD, Conn., May 8 It,s time for a break ... of their loved ones, according to Caring Today,magazine, the Number One resource ...
... Software training supplements counseling, could also treat other ... -- The use of a computer-assisted training program, ... stay abstinent longer than counseling alone, a Yale ... , The trial included 77 people who sought ...
... handheld inventory management tool to GHX electronic trading ... replenishment process, LOUISVILLE, Colo., May 8 ... a new version of its SalesAccelerator,handheld inventory management ... addition,to barcodes. Using this expanded capability, healthcare manufacturers ...
... by the National Kidney Foundation of the National Capital ... Staind and Live, as,well as Seether, Finger 11, Chevelle, ... Standing Contest, The Blackjacks; top chili chefs from,around the ... Model finalist Sara Albert., What: 29th Annual DC101 ...
... for April, 2008, WASHINGTON, May 8 ... for April, 2008:, The Bulletin, which is ... site (http://www.ncd.gov ), brings you the latest ... to the NCD listserv, go to, http://listserv.access.gpo.gov, ...
... 2008 Wouldnt it be nice if our doctors ... particular medication" This question is important because research ... to respond to treatments, but inevitably, differences among groups ... about groups of patients may not apply to individuals ...
Cached Medicine News:Health News:Do You Need a Caregiving Break Today? 2Health News:Do You Need a Caregiving Break Today? 3Health News:Computer Program Helps Drug Abusers Stay Clean 2Health News:GHX Mobile Solutions' SalesAccelerator Tool Adds Capability to Read RFID Tags, as Well as Barcodes 2Health News:NCD - 30 Years of Disability Policy Leadership - 1978 - 2008 2Health News:NCD - 30 Years of Disability Policy Leadership - 1978 - 2008 3Health News:NCD - 30 Years of Disability Policy Leadership - 1978 - 2008 4Health News:Improving anxiety treatment through the help of brain imaging: A potential future treatment strategy 2
The Perfecta PDA components provide the design and material choice imperative in today's cost conscious medical climate....
Cementless hip stem revisions offering optimal version setting for each patient. Compatible with modular link ceramic or cobalt chromium femoral heads with up to 4 neck lengths, or the link saddle de...
The proximally modular S-ROM Total Hip System provides custom capability at non-custom prices and is competitive with conventional porous coated systems....
The proximally modular S-ROM Total Hip System provides custom capability at non-custom prices and is competitive with conventional porous coated systems....
Medicine Products: