Navigation Links
AcelRx Pharmaceuticals Reports Positive Results from a Clinical Trial of Sublingual Sufentanil/Triazolam NanoTab(TM) Combination (ARX-03) in Treating Procedural Pain and Anxiety
Date:1/12/2009

Results Show Successful Clinical Validation of Pharmacodynamic Effect

REDWOOD CITY, Calif., Jan. 12 /PRNewswire/ -- AcelRx Pharmaceuticals, Inc., an emerging specialty pharmaceutical company focused on the treatment of intermittent and acute medical conditions with an initial emphasis on pain management, today announced positive results from a Phase 1 clinical study evaluating the safety, tolerability and efficacy of the company's proprietary sublingual sufentanil (opioid) and triazolam (benzodiazepine) NanoTab(TM) combination product candidate (ARX-03). The product is designed to address the current unmet need for a non-invasive product to provide sedation and analgesia for an increasing number of office-based procedures.

The study demonstrated that administration of ARX-03 resulted in a statistically significant increase in sedation levels for the 10mcg sufentanil/200mcg triazolam dosage strength in both a younger cohort (age range 18-60 years; p=0.009) and an older cohort (age range of 61-80 years; p=0.003) as compared to sublingual sufentanil alone. These data were collected using the Richmond Agitation-Sedation Scale (RASS), a validated and objective test for assessment of sedation levels. The average onset of sedation was 20-30 minutes for the higher dosage strength in each study cohort.

Additionally, sublingual administration of the sufentanil/triazolam combination was found to be safe and well tolerated. Based on these positive results, AcelRx intends to further advance clinical development of ARX-03 in 2009.

"We believe the results of this trial are particularly valuable as they offer clinical evidence well beyond what is expected from a typical Phase 1 study. Not only have we shown ARX-03 to be safe and well-tolerated, we have also demonstrated significant pharmacodynamic findings with a randomized, double-blind design that spanned different age groups and multiple dosage level
'/>"/>

SOURCE AcelRx Pharmaceuticals, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Auxilium Pharmaceuticals, Inc. Receives Clearance to Resume Clinical Trials for XIAFLEX(TM)
2. Vion Pharmaceuticals Completes Accrual of 85 Patients to its Pivotal Phase II Trial of Cloretazine(R) (VNP40101M) in Elderly AML
3. Solvay Pharmaceuticals, Inc. and Wyeth Pharmaceuticals Announce Receipt of an FDA Action Letter for Bifeprunox, an Investigational Treatment for Schizophrenia
4. Callisto Pharmaceuticals Opens Additional Sites for Phase II Clinical Trial of Atiprimod in Advanced Carcinoid Cancer Patients
5. WallSt.net (www.wallst.net) Updates the Investment Community Through an All-New Interview With RegeneRx Biopharmaceuticals CEO
6. Quark Pharmaceuticals, Inc. Presented Positive Preclinical Results of Systemic RNAi Compound for Acute Renal Failure (ARF)
7. Peregrine Pharmaceuticals Doses First Patient in Cotara(R) Phase II Brain Cancer Trial In India
8. Nabi Biopharmaceuticals Announces Second Quarter 2007 Financial Results
9. Access Pharmaceuticals Provides Update on Clinical Development Plan of ProLindac
10. Quark Pharmaceuticals Extends Research Agreement with State University of New York for Proprietary siRNA Compounds for Acute Hearing Loss
11. Acura Pharmaceuticals, Inc. Secures Financing to Fund Pivotal Phase III Clinical Trial for Lead Aversion(R) Technology Product Candidate
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/22/2014)... Pa. , July 22, 2014  Eyeon Therapeutics ... dry eye treatment based on a charged hydrophilic polymer ... The product has been shown to be safe and ... Mitchnick , MD, CEO states, "This first set of ... a long way to moving this technology into the ...
(Date:7/22/2014)... , July 22, 2014 Elekta (NSE:EKTAb) and ... that The Christie NHS Foundation Trust ( Manchester, ... a consortium whose mission is to develop the clinical ... radiation therapy system. Such a system would, in principle, ... cancer targets. "The Christie was an ...
(Date:7/22/2014)... SCHOFIELD, Wis. , July 22, 2014 /PRNewswire/ ... and marketer of over-the-counter (OTC) medicinal and healthcare ... corporate sponsor of Operation Troop Aid. ... said Russell Mitchell , CEO and Chairman ... men and women in combat zones experience migraines ...
Breaking Medicine Technology:Particle Sciences and Eyeon Therapeutics Receive Patent on Novel Dry Eye Technology 2The Christie Hospital joins Elekta and Philips research consortium to develop MRI-guided radiation therapy system for cancer treatment 2The Christie Hospital joins Elekta and Philips research consortium to develop MRI-guided radiation therapy system for cancer treatment 3The Christie Hospital joins Elekta and Philips research consortium to develop MRI-guided radiation therapy system for cancer treatment 4PuraMed BioScience Partners with Operation Troop Aid to Sponsor Care Packages 2PuraMed BioScience Partners with Operation Troop Aid to Sponsor Care Packages 3
(Date:7/23/2014)... PartnerTech Inc. , a major systems integration ... von Uexkull to their facilities, June 6, 2014 as ... a top trade official from the Embassy of Sweden, ... bring awareness and insight to the business community concerning ... , As an expert on global economy, von Uexkull ...
(Date:7/23/2014)... On July 4th, at the age of 70, ... a first place prize in her age group at the Firecracker ... waited until she was in her forties before becoming an ordained ... start running. Not one to do anything halfway, she launched her ... Kitty, the decision to begin running started five years ago at ...
(Date:7/22/2014)... July 22, 2014 Ticket Down ... vs. Manchester City tickets at Sporting Park in Kansas ... on Wednesday, July 23rd. Tickets can be conveniently printed ... Ticket Down can be reached toll free at 1-877-870-3653. ... are authentic and covered by Ticket Down's customer satisfaction guarantee. ...
(Date:7/22/2014)... 23, 2014 Provectus has ... From now on, in addition to working with the ... for Google Glass as well as the creation of ... A dynamic lifestyle requires special gadgets for work, leisure ... found application in healthcare, logistics, travelling, sports, education, science ...
(Date:7/22/2014)... 2014 Obtaining a bachelor’s degree in ... who have hands-on medical experience. The School of Nursing ... announced the launch of an accelerated nursing degree program ... new program, the UNCG Veterans Access Program (VAP), will ... veterans. With some prior college credit, veterans who are ...
Breaking Medicine News(10 mins):Health News:Swedish Official Tours PartnerTech’s U.S. Facility 2Health News:Swedish Official Tours PartnerTech’s U.S. Facility 3Health News:Naperville, Ilinois’ Monarch Landing Resident Wins First Place in 5K Run 2Health News:Sporting Kansas City vs. Manchester City Tickets: Ticket Down Has Slashed Ticket Prices for Manchester City vs. Sporting Kansas City on July 23rd 2Health News:Provectus Announces Development for Google Glass and Wearables 2Health News:UNCG School of Nursing Fast-Tracks Medically Trained Veterans 2
... Epidural hematoma, is a blood clot between the brain and ... Natasha Richardson died from a blunt impact to the head, ... Monday on a beginner,s ski slope in Canada. , The ... hematoma due to blunt impact to the head," said medical ...
... Encourages Dialog between Patients and PhysiciansALEXANDRIA, Va., March 19 ... their end-of-life wishes with their physicians had significantly lower ... found that these conversations between patients and physicians led ... and resulted in a far more peaceful death for ...
... less invasive than deep brain stimulation, researchers say ... with Parkinson,s-like symptoms walked and moved normally again ... frequency electrical currents, a new study shows. , ... has the potential to be an important new ...
... company cofounded by Beth Israel Deaconess Medical Center (BIDMC) ... has announced that it has closed an $8M Series ... Life Sciences (SVLS) and MedImmune Ventures. , The company ... T-cells, with their first program focusing on treatments for ...
... adds features that benefit both patients and health ... a leading international provider of innovative stroke rehabilitation ... www.saebo.com . The new site is designed ... upper extremity stroke rehab products, while making the ...
... of Pittsburgh School of Medicine have begun testing a vaccine ... at high risk for developing the disease. If shown to ... of repeated invasive surveillance tests, such as colonoscopy, that are ... cancer takes years to develop and typically starts with a ...
Cached Medicine News:Health News:Natasha Richardson Died From Head Trauma: Autopsy 2Health News:Natasha Richardson Died From Head Trauma: Autopsy 3Health News:Discussions About End-of-Life Care Reduce Healthcare Costs in Last Week of Life 2Health News:New Parkinson's Treatment Shows Promise in Animals 2Health News:New Parkinson's Treatment Shows Promise in Animals 3Health News:Biotech company cofounded by BIDMC scientists targets natural killer T-cells 2Health News:Saebo Expands Internet Presence With Launch of New Website 2Health News:Saebo Expands Internet Presence With Launch of New Website 3Health News:Pitt vaccine to prevent colon cancer being tested in patients 2
... best value in high performance electronic pipetting!, ... lightweight design reduce hand fatigue and strain ... tip ejector , Color coding for easy ... for greater performance use Hamilton AdvanTip Low ...
... Research pro Electronic Pipette is ideal for ... Its easy-to-follow display, ergonomically-placed operating buttons, and ... reverse pipetting and diluting make this a ... functions of a manual pipette without any ...
... The Research pro Electronic Pipette is ... the laboratory. Its easy-to-follow display, ergonomically-placed operating ... pipetting, dispensing, reverse pipetting and diluting make ... the simple functions of a manual pipette ...
... for Unparalleled Comfort Pick one of our ... Notice the trigger and ejector positionsright where they ... pipettors are ergonomically designed to help avoid repetitive ... Productivity In The Palm Of Your Hand ...
Medicine Products: