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Accuray Launches First Study to Compare CyberKnife® SBRT to Surgery and IMRT for Treatment of Early-Stage Prostate Cancer
Date:4/26/2012

, Charite–Universitatsmedizin in Germany, Erasmus MC-Daniel den Hoed Cancer Center in The Netherlands, and Mount Vernon Cancer Centre in the UK and is comprised of two parallel randomized arms:

  • Patients considered candidates for surgery, either by clinician recommendation or patient choice, are randomized to either laparoscopic prostatectomy (performed manually or through robotic assistance using da Vinci) or CyberKnife prostate SBRT.
  • Non-surgical candidates or patients who refuse surgery will be randomized to either CyberKnife prostate SBRT or conventionally fractionated IMRT.

The ultimate goal of the study is to compare the outcomes of CyberKnife prostate SBRT, in terms of efficacy, toxicity and quality of life to da Vinci prostatectomy, manual laparoscopic prostatectomy and conventionally fractionated IMRT for early-stage, organ-confined prostate cancer. The study employs the leading quality of life tools to measure erectile function preservation, urinary and rectal toxicity, urinary incontinence and other scores related to general post treatment side effects. The study is expected to involve 30-40 centers globally and accrue more than 1,000 patients who will be followed for 10 years. The study leaders anticipate collecting and reporting data outcomes at several interim points including one, two and five years post-treatment.

"In light of a lack of definitive, comparative data supporting any one option as the best treatment choice, about 75 percent of low risk prostate cancer patients in the US receive surgery," said Dr. Nicholas van As, M.D, consultant clinical oncologist at the Royal Marsden NHS Foundation Trust in London. "The goal of the PACE study is to create the data needed to compare outcomes of treatment with CyberKnife prostate SBRT to surgery and  IMRT, which are the accepted standard treatments for organ confined prostate cancer, to allow informed treatment decision
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SOURCE Accuray Incorporated
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