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According to Surveyed Oncologists in the EU5, Zytiga Has Heavily Penetrated Second-Line Treatment of Metastatic Castrate-Resistant Prostate Cancer (mCRPC) and is Displacing Jevtana to Later-Line mCRPC
Date:3/18/2013

aly agree. Zytiga's more favorable side-effect profile, convenient oral administration, and mechanism of action likely explain why such a substantial percentage of physicians expect this trend. At the end of 2015, despite the anticipated approval of three new therapies—Medivation/Astellas Pharma's Xtandi, Algeta/Bayer HealthCare's radium-223, and Takeda/Millennium's orteronel—Zytiga will maintain its position as the favored second-line mCRPC therapy among surveyed EU5 physicians.

This report also finds that, in addition to robust efficacy, therapeutic innovation and demonstrable downstream cost savings are key market access levers that will encourage EU5 payers to think beyond an emerging agent's proposed price tag. Pharmaceutical innovation is key to reimbursement decision making in Italy and Spain, and, in the former, inclusion on AIFA's innovative drugs list ensures funding across regions.

"Savings in hospitalization and supportive care costs, as well as the societal benefits of improving quality of life, will help encourage uptake within countries following admission to reimbursement," said Decision Resources Senior Director Rachel Webster , Ph.D. "Costs associated with management of Jevtana's side effects may well have contributed to NICE's decision on its lack of cost-effectiveness. Furthermore, the United Kingdom's value-based pricing system, set to be implemented at the end of this year, will pave the way for consideration of wider societal benefits and associated cost savings, and the principles of this concept are increasingly evident across the EU5."

About Decision Resources
Decision Resources (www.decisionresources.com) is a world leader in market research publications, advisory services and consulting designed to help clients shape strategy, allocate
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