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Access Pharmaceuticals Provides Update on Clinical Development Plan of ProLindac
Date:8/20/2007

Company Announces Clinical Trial Plans for 4Q07/1Q08

DALLAS, Aug. 20 /PRNewswire-FirstCall/ -- Access Pharmaceuticals, Inc. (OTC Bulletin Board: ACCP) provided today an update on the clinical development plan of ProLindac, its novel DACH platinum polymer prodrug, and announced plans for additional human clinical trials to be initiated in late 2007/ early 2008. The ongoing clinical trial in recurrent ovarian cancer patients, designed to optimize single agent dosing through schedule diversification and dose escalation, is currently successfully completing the enrollment of its third dose cohort.

"The excellent safety profile, especially the lack of neuro- and nephrotoxicity after multiple treatment cycles, makes it possible for us now to submit an amendment to the ongoing trial which will allow us to further and aggressively explore dosing and schedule optimization in a quicker manner," stated Dr. Esteban Cvitkovic, Vice Chairman (Europe) and recently appointed Senior Director Clinical Oncology. "The recurrent ovarian patient population is an increasingly challenging indication from a regulatory standpoint. Therefore we will continue to be careful with patient eligibility in this single agent trial. We have observed a pharmacological effect at what are still sub-toxic doses which leaves room to increase the therapeutic index in this specific indication. Moreover, this will also allow us to implement combination drug trials, the other main path to obtain further clinical evidence, in a variety of indications, of the full potential for this very promising agent."

Access Pharmaceuticals is currently planning ProLindac drug combination trials to be initiated in the fourth quarter of 2007/early 2008. As has been clinically demonstrated with Eloxatin, Sanofi's marketed DACH platinum, ProLindac's antitumor effect is expected to be synergistic when utilized in combination with other reference anti-cancer agents, such as 5-fluorourcil (5FU) or
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SOURCE Access Pharmaceuticals, Inc.

Copyright©2007 PR Newswire.

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