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Access Pharmaceuticals Presents new Combination Data on the Company's Angiolix(R) Therapeutic Monoclonal Antibody
Date:1/26/2009

New data demonstrates that Angiolix has similar efficacy to Avastin alone and in combination with other chemotherapeutics, with potentially less side-effects; study validates results seen in Previous Breast Cancer Model

DALLAS, Jan. 26 /PRNewswire-FirstCall/ -- ACCESS PHARMACEUTICALS, INC. (OTC Bulletin Board: ACCP) presented new data this week on its proprietary humanized monoclonal antibody, Angiolix, which confirmed that Angiolix(R) binds with high affinity to the its target, lactadherin, resulting in anti-angiogenesis and significant tumor growth inhibition in MCF-7 and MX-1 breast cancer xenografts. Its anticancer activity is greatly enhanced when given in combination with chemotherapy. The efficacies determined for Angiolix combinations were comparable to those of Avastin combinations. The mechanism of action of Angiolix is considerably more tumor specific than that of Avastin, potentially giving fewer adverse side-effects. The preclinical studies were conducted at Imperial College London and presented at the International Congress on Anti-Cancer Treatment, a World Leading Educational Congress, held in Paris, France, Palais des Congres 3rd - 6th February 2009.

Data was also presented on the ability of Angiolix to bind to various proteins. Dr. Agamemnon Epenetos, Access Pharmaceuticals' Chief Scientific Officer, Europe explained, "Competitive binding experiments with a variety of ligands shows that Angiolix binds lactadherin selectively. This provides an excellent insight into Angiolix's tumor selective mechanism. Angiolix(R) is a promising novel agent for anti-angiogenic cancer therapy. Angiolix has proven to be an effective anticancer drug candidate, in preclinical trials, that is much more tumor specific than Avastin, because it has a tumor specific target. By comparison, Avastin binds VEGF which is widely expressed by many normal tissues and supports many essential physiological functions."

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SOURCE Access Pharmaceuticals, Inc.
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