Navigation Links
Acacia Pharma Initiates Phase II Study With APD403 in Chemotherapy Induced Nausea & Vomiting (CINV)
Date:10/30/2013

CAMBRIDGE, England, October 30, 2013 /PRNewswire/ --

Acacia Pharma, a pharmaceutical company specialising in the development of drugs for supportive care, announces the initiation of a Phase II study of APD403 in the prevention of chemotherapy-induced nausea & vomiting (CINV). CINV remains a clinically significant problem in cancer patients receiving emetogenic chemotherapy despite the availability of a range of anti-emetic medications.

CINV occurs in approximately 70% of all cancer patients receiving chemotherapy and in 90% of those receiving highly emetogenic chemotherapy (HEC). It is one of the major side effects of cancer therapy and a considerable concern for patients. There are two major types of CINV, referred to as acute CINV which occurs on the day of treatment, and delayed CINV which occurs up to five days following chemotherapy. Despite the improvements in managing CINV there remains a clear unmet need to reduce the incidence of nausea, especially in delayed CINV, as standard regimens are relatively effective at stopping patients being sick (vomiting) but much less so at stopping them feeling sick (nausea), which is often the most distressing symptom.

The Phase II study is taking place in around 25 major centres in the UK, Denmark, Germany and the USA and aims to recruit 315 cancer patients receiving HEC. The trial compares 3 doses of APD403 against placebo in the delayed phase of CINV. The primary endpoint is no vomiting or retching and no requirement for anti-emetic rescue medication for 5 days after the start of chemotherapy administration. The incidence and severity of nausea is being studied as a secondary endpoint.

Acacia Pharma has previously generated positive Phase IIa clinical data when the drug was given prophylactically to cancer patients being treated with the HEC, cisplatin. These data showed APD403 has t
'/>"/>

SOURCE Acacia Pharma
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Acacia Pharma Announces Excellent Phase II Results for APD421 in Post-Operative Nausea & Vomiting (PONV)
2. Financial Results, Appointments, Earnings Conferences, and Partnerships - Research Report on New Oriental Education & Technology, Acacia Research, DeVry, Capella Education, and Qiagen NV
3. Study Finds Utilizing Integrated Medical and Pharmacy Data Improves Ability to Forecast Use of High-cost Specialty Treatments
4. Report Presents a Framework for Successful New Oncology Product Launches in the Pharmaceutical Sector
5. WuXi PharmaTech Files 2011 Annual Report on Form 20-F
6. Savient Pharmaceuticals to Hold First Quarter 2012 Financial Results Conference Call on Wednesday, May 9, 2012
7. Pharmaceutical Industry Service Company Awarded The UKs Most Prestigious Business Accolade in Recognition of Outstanding Achievement in International Trade
8. Academy of Managed Care Pharmacy (AMCP) Installs 2012-2013 Board of Directors
9. Auxilium Pharmaceuticals to Present at the Deutsche Bank 37th Annual Healthcare Conference
10. Simcere Pharmaceutical Group to Announce First Quarter 2012 Financial Results on Wednesday, May 9, 2012
11. Nouveau Life Pharmaceuticals (HRID) Contracts with U.S. Manufacturer to Produce New Female Supplement
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/5/2015)... (Family Features) Which health screenings and exams ... adults, monitoring your weight, cholesterol, and blood pressure is ... about vision care? Photo - ... 40s, they often start to notice small changes in ... job performance. Whether having difficulty reading a book or ...
(Date:5/5/2015)... and NIJMEGEN, the Netherlands ... medical device company developing lower esophageal sphincter (LES) ... long-term, 3-year, positive safety and efficacy results. The ... of both heartburn and regurgitation and the "gold-standard" ... test) with near-complete elimination of dependence on daily ...
(Date:5/5/2015)... , May 5, 2015  IQPC,s 19 th ... to announce the chairman of the Summit Mr. Phani ... He will be joined by the expert speaker faculty including ... this May 11 – 12, at The Hotel Kabuki in ... agenda is available for download on the event website, which ...
Breaking Medicine Technology:Eye Care as You Age 2Eye Care as You Age 3Eye Care as You Age 4Excellent three year results of EndoStim therapy for severe reflux disease presented at the SAGES Annual Meeting in Nashville. 2Excellent three year results of EndoStim therapy for severe reflux disease presented at the SAGES Annual Meeting in Nashville. 3Phani Bidarahalli from Wipro to chair the upcoming 19th Software Design for Medical Devices Summit in San Francisco 2
... COLUMBUS, Ohio, June 15, 2011 EndoSphere Inc. ... and international issued and pending patents, announced today that ... company a patent covering the use of its endoscopically ... obesity and type 2 diabetes. U.S. Patent ...
... Corp. (the "Company") (NASDAQ OTC: VSHC) is pleased to be ... fourth quarter of fiscal 2011 to be between $1,050,000 and ... high since inception and represents a substantial increase from previous ... provide further guidance regarding year end revenues for the entire ...
Cached Medicine Technology:EndoSphere Inc. Receives Patent for Obesity Treatment 2Visual Healthcare Provides Fourth Quarter Revenue Guidance 2
(Date:5/5/2015)... 05, 2015 The 2015 Crystal Ball, hosted ... benefit their global research, outreach and patient advocacy programs. The ... awards ceremony that attracted hundreds of supporters. , The 2015 ... of the hepatitis B virus (HBV) by Dr. Baruch S. ... Nobel Prize in Medicine for his discovery of the virus ...
(Date:5/5/2015)... (PRWEB) May 05, 2015 Baptist Medical ... Commission on Cancer (CoC) of the American College of ... program must meet more than 30 Commission on Cancer ... a survey process, and maintain levels of excellence in ... When patients choose to seek care locally at a ...
(Date:5/5/2015)... " QuickPick Travel ” was featured on NewsWatch as part ... medium, and large businesses making an impact in their industry. ... conducted the business review and shared with viewers how this ... of vacation for free. , Vacations are a sought-after opportunity ... And when people are preparing for vacations, they’re used to ...
(Date:5/5/2015)... York, NY (PRWEB) May 05, 2015 ... Platform that enables businesses to deploy Mobile Engagement Campaigns ... Constant Contact . ProTexting clients can now leverage the ... reach by collecting and syncing subscribers’ e-mail addresses into ... says “We have recognized that the growing trend of ...
(Date:5/5/2015)... Orange, New Jersey (PRWEB) May 05, 2015 ... system, today announced the launch of a new healthy ... Talbot, a season two semi-finalist on Bravo’s Top Chef, ... dishes that promote wellness and healthy living. In ... an enhanced Wellness Website and the videos will be ...
Breaking Medicine News(10 mins):Health News:Hepatitis B Foundation Marks 50th Anniversary of HBV Discovery at its Crystal Ball Gala 2Health News:Hepatitis B Foundation Marks 50th Anniversary of HBV Discovery at its Crystal Ball Gala 3Health News:Baptist Medical Center Jacksonville Receives National Cancer Reaccreditation 2Health News:Baptist Medical Center Jacksonville Receives National Cancer Reaccreditation 3Health News:Baptist Medical Center Jacksonville Receives National Cancer Reaccreditation 4Health News:A Platform to Plan the Perfect Vacation was Featured on NewsWatch Television 2Health News:ProTexting SMS Mobile Marketing platform integrates with Constant Contact 2Health News:ProTexting SMS Mobile Marketing platform integrates with Constant Contact 3Health News:Barnabas Health Teams Up With Celebrity Chef Sam Talbot To Launch "Life Is Better Healthy" Cooking Video Series 2Health News:Barnabas Health Teams Up With Celebrity Chef Sam Talbot To Launch "Life Is Better Healthy" Cooking Video Series 3
... is a painful degenerative disease which is affecting a ... no longer limited to old people even the younger ... is some good news for those affected. , ... a naturally occurring sulphur compound, can relieve pain and ...
... to the latest issue of Archives of Pediatrics & Adolescent ... the age group of two to six years old were ... the same in movies or if parents smoked as well. ... children two to six years old were nearly four times ...
... Using an alcohol-based hand sanitizer gel significantly reduces the ... of the 292 families studied, half of the families, ... a 59 % reduction in the spread of illness ... using hand sanitizer were excluded from the study. Half ...
... elevate the role of fibres further by stating that ... plaque build-up in the arteries in postmenopausal women.// ... with a decreased risk of heart disease and death. ... fruit, and vegetables, and refined grain products on the ...
... and his colleagues from National University of Singapore studied ... Chromosomal aberrations leading to cancer// in Plutonium plant workers. ... biomarkers for easy detection and identification of chromosome aberrations. ... between complex chromosome aberrations and disease condition which would ...
... using antiplatelet medication called clopidogrel before coronary angioplasty ... cardiovascular problems like heart attacks, or strokes.// The ... of JAMA. ,Dual antiplatelet therapy following percutaneous ... as ticlopidine or clopidogrel along with aspirin helps ...
Cached Medicine News:Health News:Alcohol based sanitizer found to reduce illness in families 2Health News:Medicines Used In Antiplatelet Therapy Can Reduce Heart Attacks And Strokes 2
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: