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Absorption Systems announces novel test platform for interactions with the BCRP transporter
Date:7/27/2012

EXTON, Pa., July 27, 2012 /PRNewswire/ -- Absorption Systems, a world leader in developing novel test systems for drug transporters, announces the availability of a long-awaited assay platform for the human BCRP transporter, also known as breast cancer resistance protein. Cell biologists at the company have successfully over-expressed BCRP in a stable manner in the MDCK cell line, thereby creating BCRP-MDCK cells, the latest addition to its CellPort Technologies® product line. The unique, new BCRP assay system will enable drug developers to test new drug candidates for interactions with BCRP, which is involved in drug clearance, resistance of tumors to anticancer drugs, and drug-drug interactions (DDIs).

DDIs, which can lead to side effects, therapeutic failure, or death, remain an underappreciated healthcare problem. The risk is particularly high among the elderly, due to the fact that most elderly people take multiple medications. According to an article in the Journal of the American Medical Association, as many as 2.2 million older Americans are at risk of a major DDI. For example, evidence suggests that BCRP is involved in the clearance from the body of methotrexate, a drug that is used to treat rheumatoid arthritis, psoriasis, and cancer. Thus, any patient taking methotrexate as well as another drug that interferes with the action of BCRP could be at risk for a DDI and a greater likelihood of severe side effects. The new BCRP-MDCK cells from Absorption Systems are the basis of a sensitive test system to screen new drug candidates for inhibition of BCRP.

Development of the new BCRP test system was spearheaded by Absorption Systems' Chief Scientist, '/>"/>

SOURCE Absorption Systems
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