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Absorption Systems Scientists Publish Peer-reviewed Paper on a Key Drug Transporter
Date:9/10/2013

EXTON, Pa., Sept. 10, 2013 /PRNewswire/ -- The preclinical contract research organization Absorption Systems, a global leader in pharmacokinetic testing of drugs and safety testing of medical devices, announces the publication of a peer-reviewed paper in the highly respected Journal of Pharmaceutical Sciences. The lead author was Jibin Li, Ph.D. In the paper, company scientists studied P-glycoprotein (P-gp), a transport protein that is known to be involved in drug-drug interactions, which can cause potentially dangerous side effects in some patients.

In one commonly used in vitro model, a cell line named MDR1-MDCK, human P-gp is genetically over-expressed in a dog kidney cell line, which already contained the canine version of the same transporter. In order to correct for the contribution of the canine P-gp, the amount of transport measured in the same cells without the human protein is routinely subtracted out. But Absorption Systems scientists found that this is an over-correction, because the canine transporter is expressed at a lower level in the cells that also express the human version. The result can be a false negative, meaning that a drug that really is transported by P-gp would be missed. In such cases, the drug might proceed further into development without anyone being aware of the risk of a potential drug-drug interaction.

This paper will improve the accuracy of data interpretation with this test system. As a result, potentially unsafe drugs will be weeded out sooner and the drugs that do make it into clinical trials will be safer. The paper was selected for inclusion in a special issue of the journal, dedicated in honor of Professor Leslie Z. Benet.

Ismael Hidalgo, Chief Scientist of Absorption Systems, comment
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SOURCE Absorption Systems
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