Navigation Links
Absorption Systems Scientists Publish Peer-reviewed Paper on a Key Drug Transporter
Date:9/10/2013

EXTON, Pa., Sept. 10, 2013 /PRNewswire/ -- The preclinical contract research organization Absorption Systems, a global leader in pharmacokinetic testing of drugs and safety testing of medical devices, announces the publication of a peer-reviewed paper in the highly respected Journal of Pharmaceutical Sciences. The lead author was Jibin Li, Ph.D. In the paper, company scientists studied P-glycoprotein (P-gp), a transport protein that is known to be involved in drug-drug interactions, which can cause potentially dangerous side effects in some patients.

In one commonly used in vitro model, a cell line named MDR1-MDCK, human P-gp is genetically over-expressed in a dog kidney cell line, which already contained the canine version of the same transporter. In order to correct for the contribution of the canine P-gp, the amount of transport measured in the same cells without the human protein is routinely subtracted out. But Absorption Systems scientists found that this is an over-correction, because the canine transporter is expressed at a lower level in the cells that also express the human version. The result can be a false negative, meaning that a drug that really is transported by P-gp would be missed. In such cases, the drug might proceed further into development without anyone being aware of the risk of a potential drug-drug interaction.

This paper will improve the accuracy of data interpretation with this test system. As a result, potentially unsafe drugs will be weeded out sooner and the drugs that do make it into clinical trials will be safer. The paper was selected for inclusion in a special issue of the journal, dedicated in honor of Professor Leslie Z. Benet.

Ismael Hidalgo, Chief Scientist of Absorption Systems, commented that, "This work helps explain some historical results that have always been somewhat puzzling. It's rewarding to contribute to a better understanding of such a well-characterized test system at this point, more than 25 years after it was first created."

About Absorption Systems
Absorption Systems, founded in 1996, assists pharmaceutical, biotechnology and medical device companies in identifying and overcoming ADMET (Absorption, Distribution, Metabolism, Excretion and Toxicity) barriers in the development of drugs, biologics and medical devices. The company's mission is to continually develop innovative research tools that can be used to accurately predict human outcomes or to explain unanticipated human outcomes when they occur. The CellPort Technologies® platform, a suite of human cell-based test systems for drug transporter characterization, exemplifies Absorption Systems' commitment to innovation and is soon to be an industry standard for in vitro drug interaction assessment. Absorption Systems, with facilities near Philadelphia, PA, in San Diego, CA, and in Panama, serves customers throughout the world. For information on the company's comprehensive contract services and applied research programs, please visit www.absorption.com.  

Chris Bode
Absorption Systems
1-601-280-1451
cbode@absorption.com
www.absorption.com


'/>"/>
SOURCE Absorption Systems
Copyright©2012 PR Newswire.
All rights reserved

Related medicine technology :

1. Lexicon Presents Preclinical Data On LX2761, a New Clinical Candidate for Diabetes Designed to Reduce Glucose Absorption From Gastrointestinal Tract
2. Vatsala Naageshwaran of Absorption Systems to Present at Disso 2013 International Conference in Mumbai, India on May 3rd
3. Absorption Pharmaceuticals to Receive Patent for Premature Ejaculation Topical Medication
4. Absorption Systems Partners with Synerzys to Promote Biopharmaceutics Classification System (BCS) Testing of Drugs
5. Absorption Systems Registers with FDA as a Generic Drug Facility under GDUFA
6. Absorption Systems announces novel test platform for interactions with the BCRP transporter
7. National Diabetes Volunteer Leadership Council (NDVLC) Urges FDA to Enforce Stringent Accuracy Standards for Blood Glucose Monitoring Systems
8. Global Endoscopy Systems Industry
9. Global Medical Laser Systems Industry
10. Global Medical Oxygen Systems Industry
11. John Ault Appointed Director of Business Development for MedTek Systems LLC
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2017)... "Chemotherapy Induced Neutropenia (CIN) – Market Insights, Epidemiology and Market Forecast-2023" ... of the Chemotherapy Induced Neutropenia for the seven major markets i.e., ... ( France , Germany , ... Japan , as well as rest of ... The Report covers the therapeutics market revenue, treatment practice ...
(Date:3/28/2017)... -- "US Cancer Generics Market Outlook 2022" report gives ... analysis related to the emergence and integration of ... US. The report analyzes various clinical and non-clinical ... drugs in recent years. The introduction of generics ... for various stake holders involved US cancer drug ...
(Date:3/28/2017)... TORONTO , March 28, 2017 /PRNewswire/ - ... service medical device development firm, announced today that it ... Toronto -based medical device industrial design and productization ... companies throughout North America with ... device talent spanning the design, engineering, regulatory, and manufacturing ...
Breaking Medicine Technology:
(Date:3/28/2017)... ... ... The Radiology Business Management Association (RBMA) is pleased to announce ... director. Mr. Still was selected through a careful months-long search by the RBMA Board ... to our members, has been a part of building the RBMA since 1992,” said ...
(Date:3/28/2017)... ... March 28, 2017 , ... ... release of two biometric time and attendance tracking products: the new NCheck Cloud ... NCheck Cloud Bio Attendance uses biometric face recognition to enable users to check ...
(Date:3/28/2017)... ... March 28, 2017 , ... The Executives, Staff & Clients ... to for the Toys for Tots Literacy Campaign at their Semi-Annual Graduation and Fundraiser ... $70 billion, the U.S. ranks at number 14 internationally in literacy. Statistically, a direct ...
(Date:3/28/2017)... ... March 28, 2017 , ... ... SkyLex Advanced Surgical, Inc. is thrilled to offer the recently FDA-approved Obalon Balloon ... this procedure adds to SkyLex Advanced Surgical’s already comprehensive list of weight-loss ...
(Date:3/28/2017)... , ... March 28, 2017 , ... Silicon Valley Hair ... to announce a new blog post about women’s hair loss. Although hair transplant procedures ... loss as they age. Menopause or genetics can be two reasons a woman may ...
Breaking Medicine News(10 mins):