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Abiraterone Acetate Significantly Improved Overall Survival for Patients with Metastatic Advanced Prostate Cancer
Date:10/11/2010

ere randomly assigned 2:1 to receive abiraterone acetate (1000 mg once daily) plus prednisone/prednisolone (5 mg twice daily) (N=797), or placebo plus prednisone/prednisolone (N=398). The primary endpoint was overall survival.

About Abiraterone Acetate

Abiraterone acetate is a novel, targeted, investigational, oral androgen biosynthesis inhibitor being developed for the treatment of metastatic advanced prostate cancer that has progressed after developing resistance to conventional hormonal therapies.  This is also known as castration-resistant prostate cancer (CRPC).  

About Prostate Cancer

Prostate cancer occurs when cancer cells form in the tissues of the prostate.  The prostate is a gland located around the urethra (under the bladder) in men that produces part of the seminal fluid.  In some cases, cancer of the prostate can grow slowly compared with other cancers.  However, depending on factors including characteristics specific to the patient and the tumor, prostate cancer can also grow very quickly and spread to other places such as the lymph nodes, bones or other parts of the body. Prostate cancer is considered to be advanced once it has spread beyond the prostate region.

Globally, prostate cancer is the second most frequently diagnosed cancer in men and the fifth most common cancer overall.  More than 900,000 new cases of prostate cancer were diagnosed in 2008 and more than 258,000 men died from the disease, a 16 percent increase from 2002.  In the U.S., an estimated 217,000 new cases of prostate cancer and 32,000 related deaths are expected to be reported in 2010.  Prostate cancer represents almost one-third of all new cancer diagnoses in men (excluding basal cell carcinoma) and is the second-leading cause of cancer-related death in men.

About Ortho Biotech Oncology Research & Development, unit of Cougar Biotechnology, Inc.

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